Alkyne/Ruthenium(II) Complex-Based Ratiometric Surface-Enhanced Raman Scattering Nanoprobe for In Vitro and Ex Vivo Tracking of Carbon Monoxide
Here, we report a surface-enhanced Raman scattering (SERS) nanosensor for real-time ratiometric detection of carbon monoxide (CO) based on a ligand displacement mechanism. This nanoprobe consists of a gold–silver (Au–Ag) alloy nanoparticle core as the highly active SERS substrate, an alkyne/rutheniu...
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| Veröffentlicht in: | Analytical chemistry (Washington) 2020-01, Vol.92 (1), p.924-931 |
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| creator | Qin, Xiaojie Si, Yanmei Wu, Zhaoyang Zhang, Ke Li, Jishan Yin, Yadong |
| description | Here, we report a surface-enhanced Raman scattering (SERS) nanosensor for real-time ratiometric detection of carbon monoxide (CO) based on a ligand displacement mechanism. This nanoprobe consists of a gold–silver (Au–Ag) alloy nanoparticle core as the highly active SERS substrate, an alkyne/ruthenium(II) (alkyne/Ru(II)) complex immobilized on the surface as the CO-sensing element, and a porous silica shell to improve the stability and biocompatibility of the particle. Displacement of the alkyne ligand by CO results in a decrease of the alkyne vibrations and an increase of the metal carbonyl complex signals, thus allowing the effective ratiometric detection of CO in real-time. The great potential of this assay for CO detection is validated in clean buffer environments, live cells, and tissue slices. |
| doi_str_mv | 10.1021/acs.analchem.9b03769 |
| format | Article |
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This nanoprobe consists of a gold–silver (Au–Ag) alloy nanoparticle core as the highly active SERS substrate, an alkyne/ruthenium(II) (alkyne/Ru(II)) complex immobilized on the surface as the CO-sensing element, and a porous silica shell to improve the stability and biocompatibility of the particle. Displacement of the alkyne ligand by CO results in a decrease of the alkyne vibrations and an increase of the metal carbonyl complex signals, thus allowing the effective ratiometric detection of CO in real-time. The great potential of this assay for CO detection is validated in clean buffer environments, live cells, and tissue slices.</description><identifier>ISSN: 0003-2700</identifier><identifier>EISSN: 1520-6882</identifier><identifier>DOI: 10.1021/acs.analchem.9b03769</identifier><identifier>PMID: 31800217</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Alkynes ; Alkynes - chemistry ; Alloys - chemistry ; Animals ; Biocompatibility ; Biosensing Techniques - methods ; Carbon monoxide ; Carbon Monoxide - analysis ; Carbonyl compounds ; Carbonyls ; Chemistry ; Coordination Complexes - chemistry ; Coordination compounds ; Gold ; Gold - chemistry ; Hep G2 Cells ; Humans ; Ligands ; Male ; Metal Nanoparticles - chemistry ; Mice, Inbred BALB C ; Nanoalloys ; Nanoparticles ; Optical Imaging - methods ; Raman spectra ; Real time ; Ruthenium ; Ruthenium - chemistry ; Ruthenium compounds ; Shell stability ; Silica ; Silicon dioxide ; Silicon Dioxide - chemistry ; Silver ; Silver - chemistry ; Spectrum Analysis, Raman - methods ; Substrates ; Vibrations</subject><ispartof>Analytical chemistry (Washington), 2020-01, Vol.92 (1), p.924-931</ispartof><rights>Copyright American Chemical Society Jan 7, 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a376t-d066ef3b232721f689004e0163daf69065444f0873fba604e122bba6a6aad9043</citedby><cites>FETCH-LOGICAL-a376t-d066ef3b232721f689004e0163daf69065444f0873fba604e122bba6a6aad9043</cites><orcidid>0000-0001-8144-361X ; 0000-0003-0218-3042</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acs.analchem.9b03769$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acs.analchem.9b03769$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,777,781,2752,27057,27905,27906,56719,56769</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31800217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Xiaojie</creatorcontrib><creatorcontrib>Si, Yanmei</creatorcontrib><creatorcontrib>Wu, Zhaoyang</creatorcontrib><creatorcontrib>Zhang, Ke</creatorcontrib><creatorcontrib>Li, Jishan</creatorcontrib><creatorcontrib>Yin, Yadong</creatorcontrib><title>Alkyne/Ruthenium(II) Complex-Based Ratiometric Surface-Enhanced Raman Scattering Nanoprobe for In Vitro and Ex Vivo Tracking of Carbon Monoxide</title><title>Analytical chemistry (Washington)</title><addtitle>Anal. Chem</addtitle><description>Here, we report a surface-enhanced Raman scattering (SERS) nanosensor for real-time ratiometric detection of carbon monoxide (CO) based on a ligand displacement mechanism. This nanoprobe consists of a gold–silver (Au–Ag) alloy nanoparticle core as the highly active SERS substrate, an alkyne/ruthenium(II) (alkyne/Ru(II)) complex immobilized on the surface as the CO-sensing element, and a porous silica shell to improve the stability and biocompatibility of the particle. Displacement of the alkyne ligand by CO results in a decrease of the alkyne vibrations and an increase of the metal carbonyl complex signals, thus allowing the effective ratiometric detection of CO in real-time. The great potential of this assay for CO detection is validated in clean buffer environments, live cells, and tissue slices.</description><subject>Alkynes</subject><subject>Alkynes - chemistry</subject><subject>Alloys - chemistry</subject><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biosensing Techniques - methods</subject><subject>Carbon monoxide</subject><subject>Carbon Monoxide - analysis</subject><subject>Carbonyl compounds</subject><subject>Carbonyls</subject><subject>Chemistry</subject><subject>Coordination Complexes - chemistry</subject><subject>Coordination compounds</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Ligands</subject><subject>Male</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Mice, Inbred BALB C</subject><subject>Nanoalloys</subject><subject>Nanoparticles</subject><subject>Optical Imaging - methods</subject><subject>Raman spectra</subject><subject>Real time</subject><subject>Ruthenium</subject><subject>Ruthenium - chemistry</subject><subject>Ruthenium compounds</subject><subject>Shell stability</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Silicon Dioxide - chemistry</subject><subject>Silver</subject><subject>Silver - chemistry</subject><subject>Spectrum Analysis, Raman - methods</subject><subject>Substrates</subject><subject>Vibrations</subject><issn>0003-2700</issn><issn>1520-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctOwzAQRS0EgvL4A4QssYFFythOnWQJVYFKPCRe22iS2DTQ2MVOUPsV_DIuLSyRF7Y151575hJyyKDPgLMzLH0fDU7LiWr6WQEikdkG6bEBh0imKd8kPQAQEU8Adsiu928AjAGT22RHsBSCR9IjX-fT94VRZw9dO1Gm7pqT8fiUDm0zm6p5dIFeVfQB29o2qnV1SR87p7FU0chM0JQ_xQYNfSyxbZWrzSu9Q2NnzhaKauvo2NCXunWWoqnoaB4un5Y-OSzfl6zVdIiusIbeWmPndaX2yZbGqVcH632PPF-OnobX0c391Xh4fhNh6LONKpBSaVFwwRPOtEwzgFiF5kSFWmYgB3Eca0gToQuUocQ4L8IpLKwyiMUeOV75hq9-dMq3-ZvtXBinz7kQAylFIlig4hVVOuu9UzqfubpBt8gZ5MsU8pBC_ptCvk4hyI7W5l3RqOpP9Dv2AMAKWMr_Hv7X8xsHnZa_</recordid><startdate>20200107</startdate><enddate>20200107</enddate><creator>Qin, Xiaojie</creator><creator>Si, Yanmei</creator><creator>Wu, Zhaoyang</creator><creator>Zhang, Ke</creator><creator>Li, Jishan</creator><creator>Yin, Yadong</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U7</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0001-8144-361X</orcidid><orcidid>https://orcid.org/0000-0003-0218-3042</orcidid></search><sort><creationdate>20200107</creationdate><title>Alkyne/Ruthenium(II) Complex-Based Ratiometric Surface-Enhanced Raman Scattering Nanoprobe for In Vitro and Ex Vivo Tracking of Carbon Monoxide</title><author>Qin, Xiaojie ; Si, Yanmei ; Wu, Zhaoyang ; Zhang, Ke ; Li, Jishan ; Yin, Yadong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a376t-d066ef3b232721f689004e0163daf69065444f0873fba604e122bba6a6aad9043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Alkynes</topic><topic>Alkynes - chemistry</topic><topic>Alloys - chemistry</topic><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biosensing Techniques - methods</topic><topic>Carbon monoxide</topic><topic>Carbon Monoxide - analysis</topic><topic>Carbonyl compounds</topic><topic>Carbonyls</topic><topic>Chemistry</topic><topic>Coordination Complexes - chemistry</topic><topic>Coordination compounds</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Ligands</topic><topic>Male</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Mice, Inbred BALB C</topic><topic>Nanoalloys</topic><topic>Nanoparticles</topic><topic>Optical Imaging - methods</topic><topic>Raman spectra</topic><topic>Real time</topic><topic>Ruthenium</topic><topic>Ruthenium - chemistry</topic><topic>Ruthenium compounds</topic><topic>Shell stability</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>Silicon Dioxide - chemistry</topic><topic>Silver</topic><topic>Silver - chemistry</topic><topic>Spectrum Analysis, Raman - methods</topic><topic>Substrates</topic><topic>Vibrations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qin, Xiaojie</creatorcontrib><creatorcontrib>Si, Yanmei</creatorcontrib><creatorcontrib>Wu, Zhaoyang</creatorcontrib><creatorcontrib>Zhang, Ke</creatorcontrib><creatorcontrib>Li, Jishan</creatorcontrib><creatorcontrib>Yin, Yadong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical chemistry (Washington)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qin, Xiaojie</au><au>Si, Yanmei</au><au>Wu, Zhaoyang</au><au>Zhang, Ke</au><au>Li, Jishan</au><au>Yin, Yadong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alkyne/Ruthenium(II) Complex-Based Ratiometric Surface-Enhanced Raman Scattering Nanoprobe for In Vitro and Ex Vivo Tracking of Carbon Monoxide</atitle><jtitle>Analytical chemistry (Washington)</jtitle><addtitle>Anal. Chem</addtitle><date>2020-01-07</date><risdate>2020</risdate><volume>92</volume><issue>1</issue><spage>924</spage><epage>931</epage><pages>924-931</pages><issn>0003-2700</issn><eissn>1520-6882</eissn><abstract>Here, we report a surface-enhanced Raman scattering (SERS) nanosensor for real-time ratiometric detection of carbon monoxide (CO) based on a ligand displacement mechanism. This nanoprobe consists of a gold–silver (Au–Ag) alloy nanoparticle core as the highly active SERS substrate, an alkyne/ruthenium(II) (alkyne/Ru(II)) complex immobilized on the surface as the CO-sensing element, and a porous silica shell to improve the stability and biocompatibility of the particle. Displacement of the alkyne ligand by CO results in a decrease of the alkyne vibrations and an increase of the metal carbonyl complex signals, thus allowing the effective ratiometric detection of CO in real-time. The great potential of this assay for CO detection is validated in clean buffer environments, live cells, and tissue slices.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>31800217</pmid><doi>10.1021/acs.analchem.9b03769</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8144-361X</orcidid><orcidid>https://orcid.org/0000-0003-0218-3042</orcidid></addata></record> |
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| subjects | Alkynes Alkynes - chemistry Alloys - chemistry Animals Biocompatibility Biosensing Techniques - methods Carbon monoxide Carbon Monoxide - analysis Carbonyl compounds Carbonyls Chemistry Coordination Complexes - chemistry Coordination compounds Gold Gold - chemistry Hep G2 Cells Humans Ligands Male Metal Nanoparticles - chemistry Mice, Inbred BALB C Nanoalloys Nanoparticles Optical Imaging - methods Raman spectra Real time Ruthenium Ruthenium - chemistry Ruthenium compounds Shell stability Silica Silicon dioxide Silicon Dioxide - chemistry Silver Silver - chemistry Spectrum Analysis, Raman - methods Substrates Vibrations |
| title | Alkyne/Ruthenium(II) Complex-Based Ratiometric Surface-Enhanced Raman Scattering Nanoprobe for In Vitro and Ex Vivo Tracking of Carbon Monoxide |
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