Redox‐responsive polyethyleneimine‐coated magnetic iron oxide nanoparticles for controllable gene delivery and magnetic resonance imaging

Recently, theranostic candidates that provide a combination of gene delivery and image diagnosis have attracted much interest in medical research. However, there are still many challenges for their clinical applications, such as uncontrollable gene delivery, high cytotoxicity, low transfection effic...

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Veröffentlicht in:	Polymer international 2020-02, Vol.69 (2), p.206-214
Hauptverfasser:	Peng, Si, Wang, Qiu‐yue, Xiao, Xue, Wang, Rui, Lin, Juan, Zhou, Qing‐han, Wu, Li‐na
Format:	Artikel
Sprache:	eng
Schlagworte:	Coatings Crosslinking Cytotoxicity Deoxyribonucleic acid Disulfide bonds DNA Dopamine Gene therapy gene transfection Gene transfer Glutathione Image contrast Ions Iron oxides Magnetic resonance imaging Medical imaging Medical research Michael reaction MR imaging Nanoparticles Organic chemistry Physicochemical properties Polyethyleneimine Precision medicine Reagents redox‐responsive theranostics Therapeutic applications Toxicity Transfection Tumor cells Zeta potential
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