Overexpression of the yap1, PDE2, and STB3 genes enhances the tolerance of yeast to oxidative stress induced by 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine

Abstract 7-chlorotetrazolo[5,1-c]benzo[1,2,4]triazine (CTBT) is an antifungal agent that induces oxidative stress and enhances the activity of other antifungals with different modes of action. A genome-wide screening of Saccharomyces cerevisiae genomic library in the high-copy-number plasmid reveale...

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Veröffentlicht in:	FEMS yeast research 2012-12, Vol.12 (8), p.958-968
Hauptverfasser:	Drobna, Eva, Gazdag, Zoltan, Culakova, Hana, Dzugasova, Vladimira, Gbelska, Yvetta, Pesti, Miklos, Subik, Julius
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Antioxidants Cell walls Cellular Reprogramming Cellular stress response Chromatin remodeling Cyclic AMP deletion mutants DNA, Fungal - genetics Drug Tolerance Enzymatic activity Gene Expression Regulation, Fungal - drug effects Genomes Kinases Oligonucleotide Array Sequence Analysis overexpressed genes Oxidants Oxidative stress Oxidative Stress - drug effects Phosphodiesterase Protein kinase A Reactive Oxygen Species resistance RNA processing rRNA Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Analysis, DNA Signal Transduction superoxide susceptibility Toxicity Trans-Activators - genetics Trans-Activators - metabolism transcription Transcription Factors - genetics Transcription Factors - metabolism Triazine Triazines - pharmacology
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