Evidence of Saffold virus circulation in Italy provided through environmental surveillance
Saffold virus (SAFV) is an emerging human cardiovirus associated with respiratory and gastrointestinal infection, and, more recently, to symptoms related to the endocrine, cardiovascular, and neurological systems. Information about SAFV circulation in Italy is scarce. In order to provide insights in...
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| Veröffentlicht in: | Letters in applied microbiology 2020-02, Vol.70 (2), p.102-108 |
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| creator | Bonanno Ferraro, G. Mancini, P. Veneri, C. Iaconelli, M. Suffredini, E. Brandtner, D. La Rosa, G. |
| description | Saffold virus (SAFV) is an emerging human cardiovirus associated with respiratory and gastrointestinal infection, and, more recently, to symptoms related to the endocrine, cardiovascular, and neurological systems. Information about SAFV circulation in Italy is scarce. In order to provide insights into the epidemiology of SAFV in Italy, 141 raw sewage samples collected throughout Italy were tested using broad‐range nested RT‐PCR primers targeting the 5′‐NC region. Seven samples (5·0%) were confirmed as SAFV in samples collected in North, Centre and Southern Italy. Typing was attempted through amplification of the VP1 coding region, using both published and newly designed primers, and one sample was characterized as SAFV‐2.
Significance and Impact of the Study
Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential.
Significance and Impact of the Study: Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential. |
| doi_str_mv | 10.1111/lam.13249 |
| format | Article |
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Significance and Impact of the Study
Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential.
Significance and Impact of the Study: Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential.</description><identifier>ISSN: 0266-8254</identifier><identifier>EISSN: 1472-765X</identifier><identifier>DOI: 10.1111/lam.13249</identifier><identifier>PMID: 31742735</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>animal viruses ; Capsid Proteins - genetics ; Cardiovirus - classification ; Cardiovirus - genetics ; Cardiovirus - isolation & purification ; Cardiovirus B ; Cardiovirus Infections - epidemiology ; Cardiovirus Infections - virology ; detection ; environmental ; Environmental Monitoring ; Epidemiology ; Gastroenteritis ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - virology ; Genetic diversity ; genetic variation ; Geographical distribution ; Humans ; Information systems ; Italy ; Italy - epidemiology ; Neural coding ; PCR ; Prevalence ; Raw sewage ; respiratory tract diseases ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - virology ; reverse transcriptase polymerase chain reaction ; Sewage ; Sewage - virology ; Sewage disposal ; Viruses ; VP1 protein ; wastewater</subject><ispartof>Letters in applied microbiology, 2020-02, Vol.70 (2), p.102-108</ispartof><rights>2019 The Society for Applied Microbiology</rights><rights>2019 The Society for Applied Microbiology.</rights><rights>Copyright © 2020 The Society for Applied Microbiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4529-7a0cfc9479a4dbec8e1c5e995efdb09938825e215ee3fe1e5ac6aa24d1890fdd3</citedby><cites>FETCH-LOGICAL-c4529-7a0cfc9479a4dbec8e1c5e995efdb09938825e215ee3fe1e5ac6aa24d1890fdd3</cites><orcidid>0000-0001-7605-0539 ; 0000-0002-2657-100X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Flam.13249$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Flam.13249$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31742735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonanno Ferraro, G.</creatorcontrib><creatorcontrib>Mancini, P.</creatorcontrib><creatorcontrib>Veneri, C.</creatorcontrib><creatorcontrib>Iaconelli, M.</creatorcontrib><creatorcontrib>Suffredini, E.</creatorcontrib><creatorcontrib>Brandtner, D.</creatorcontrib><creatorcontrib>La Rosa, G.</creatorcontrib><title>Evidence of Saffold virus circulation in Italy provided through environmental surveillance</title><title>Letters in applied microbiology</title><addtitle>Lett Appl Microbiol</addtitle><description>Saffold virus (SAFV) is an emerging human cardiovirus associated with respiratory and gastrointestinal infection, and, more recently, to symptoms related to the endocrine, cardiovascular, and neurological systems. Information about SAFV circulation in Italy is scarce. In order to provide insights into the epidemiology of SAFV in Italy, 141 raw sewage samples collected throughout Italy were tested using broad‐range nested RT‐PCR primers targeting the 5′‐NC region. Seven samples (5·0%) were confirmed as SAFV in samples collected in North, Centre and Southern Italy. Typing was attempted through amplification of the VP1 coding region, using both published and newly designed primers, and one sample was characterized as SAFV‐2.
Significance and Impact of the Study
Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential.
Significance and Impact of the Study: Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential.</description><subject>animal viruses</subject><subject>Capsid Proteins - genetics</subject><subject>Cardiovirus - classification</subject><subject>Cardiovirus - genetics</subject><subject>Cardiovirus - isolation & purification</subject><subject>Cardiovirus B</subject><subject>Cardiovirus Infections - epidemiology</subject><subject>Cardiovirus Infections - virology</subject><subject>detection</subject><subject>environmental</subject><subject>Environmental Monitoring</subject><subject>Epidemiology</subject><subject>Gastroenteritis</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Gastrointestinal Diseases - virology</subject><subject>Genetic diversity</subject><subject>genetic variation</subject><subject>Geographical distribution</subject><subject>Humans</subject><subject>Information systems</subject><subject>Italy</subject><subject>Italy - epidemiology</subject><subject>Neural coding</subject><subject>PCR</subject><subject>Prevalence</subject><subject>Raw sewage</subject><subject>respiratory tract diseases</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - virology</subject><subject>reverse transcriptase polymerase chain reaction</subject><subject>Sewage</subject><subject>Sewage - virology</subject><subject>Sewage disposal</subject><subject>Viruses</subject><subject>VP1 protein</subject><subject>wastewater</subject><issn>0266-8254</issn><issn>1472-765X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PBCEURYnR6PpR-AcMiY0Wo8DAzFCajV_JGgs1MTaEhYdiZgaFnTX772VdtTDxNRTvcHLfRWifkhOa57TV3QktGZdraER5zYq6Eo_raERYVRUNE3wLbaf0SghpKJObaKukNWd1KUbo6XzuLfQGcHD4TjsXWovnPg4JGx_N0OqZDz32Pb6e6XaB32JYfrB49hLD8PyCoc906Dvo8x6nIc7Bt63Oxl204XSbYO_73UEPF-f346ticnt5PT6bFIYLJotaE-OM5LXU3E7BNECNACkFODslUpZNvgAYFQClAwpCm0prxi1tJHHWljvoaOXN2d4HSDPV-WRgGQLCkBTjhAhGOCMZPfyDvoYh9jmdYmXJK8qYbDJ1vKJMDClFcOot-k7HhaJELQtXuXD1VXhmD76Nw7QD-0v-NJyB0xXw4VtY_G9Sk7OblfITP2KLZQ</recordid><startdate>202002</startdate><enddate>202002</enddate><creator>Bonanno Ferraro, G.</creator><creator>Mancini, P.</creator><creator>Veneri, C.</creator><creator>Iaconelli, M.</creator><creator>Suffredini, E.</creator><creator>Brandtner, D.</creator><creator>La Rosa, G.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7ST</scope><scope>7T7</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-7605-0539</orcidid><orcidid>https://orcid.org/0000-0002-2657-100X</orcidid></search><sort><creationdate>202002</creationdate><title>Evidence of Saffold virus circulation in Italy provided through environmental surveillance</title><author>Bonanno Ferraro, G. ; Mancini, P. ; Veneri, C. ; Iaconelli, M. ; Suffredini, E. ; Brandtner, D. ; La Rosa, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4529-7a0cfc9479a4dbec8e1c5e995efdb09938825e215ee3fe1e5ac6aa24d1890fdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>animal viruses</topic><topic>Capsid Proteins - genetics</topic><topic>Cardiovirus - classification</topic><topic>Cardiovirus - genetics</topic><topic>Cardiovirus - isolation & purification</topic><topic>Cardiovirus B</topic><topic>Cardiovirus Infections - epidemiology</topic><topic>Cardiovirus Infections - virology</topic><topic>detection</topic><topic>environmental</topic><topic>Environmental Monitoring</topic><topic>Epidemiology</topic><topic>Gastroenteritis</topic><topic>Gastrointestinal Diseases - epidemiology</topic><topic>Gastrointestinal Diseases - virology</topic><topic>Genetic diversity</topic><topic>genetic variation</topic><topic>Geographical distribution</topic><topic>Humans</topic><topic>Information systems</topic><topic>Italy</topic><topic>Italy - epidemiology</topic><topic>Neural coding</topic><topic>PCR</topic><topic>Prevalence</topic><topic>Raw sewage</topic><topic>respiratory tract diseases</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - virology</topic><topic>reverse transcriptase polymerase chain reaction</topic><topic>Sewage</topic><topic>Sewage - virology</topic><topic>Sewage disposal</topic><topic>Viruses</topic><topic>VP1 protein</topic><topic>wastewater</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonanno Ferraro, G.</creatorcontrib><creatorcontrib>Mancini, P.</creatorcontrib><creatorcontrib>Veneri, C.</creatorcontrib><creatorcontrib>Iaconelli, M.</creatorcontrib><creatorcontrib>Suffredini, E.</creatorcontrib><creatorcontrib>Brandtner, D.</creatorcontrib><creatorcontrib>La Rosa, G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Letters in applied microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonanno Ferraro, G.</au><au>Mancini, P.</au><au>Veneri, C.</au><au>Iaconelli, M.</au><au>Suffredini, E.</au><au>Brandtner, D.</au><au>La Rosa, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence of Saffold virus circulation in Italy provided through environmental surveillance</atitle><jtitle>Letters in applied microbiology</jtitle><addtitle>Lett Appl Microbiol</addtitle><date>2020-02</date><risdate>2020</risdate><volume>70</volume><issue>2</issue><spage>102</spage><epage>108</epage><pages>102-108</pages><issn>0266-8254</issn><eissn>1472-765X</eissn><abstract>Saffold virus (SAFV) is an emerging human cardiovirus associated with respiratory and gastrointestinal infection, and, more recently, to symptoms related to the endocrine, cardiovascular, and neurological systems. Information about SAFV circulation in Italy is scarce. In order to provide insights into the epidemiology of SAFV in Italy, 141 raw sewage samples collected throughout Italy were tested using broad‐range nested RT‐PCR primers targeting the 5′‐NC region. Seven samples (5·0%) were confirmed as SAFV in samples collected in North, Centre and Southern Italy. Typing was attempted through amplification of the VP1 coding region, using both published and newly designed primers, and one sample was characterized as SAFV‐2.
Significance and Impact of the Study
Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential.
Significance and Impact of the Study: Prevalence, genetic diversity and geographic distribution of SAFV in Italy is currently unknown. This study represents the first detection of SAFV in sewage samples in Italy, suggesting that it is circulating in the population despite lack of clinical reporting. Whether the virus is associated with asymptomatic cases or with undetected gastroenteritis or respiratory illness is unknown. Further studies are needed to investigate on the occurrence and persistence of SAFV in water environments and its waterborne transmission potential.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>31742735</pmid><doi>10.1111/lam.13249</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7605-0539</orcidid><orcidid>https://orcid.org/0000-0002-2657-100X</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | animal viruses Capsid Proteins - genetics Cardiovirus - classification Cardiovirus - genetics Cardiovirus - isolation & purification Cardiovirus B Cardiovirus Infections - epidemiology Cardiovirus Infections - virology detection environmental Environmental Monitoring Epidemiology Gastroenteritis Gastrointestinal Diseases - epidemiology Gastrointestinal Diseases - virology Genetic diversity genetic variation Geographical distribution Humans Information systems Italy Italy - epidemiology Neural coding PCR Prevalence Raw sewage respiratory tract diseases Respiratory Tract Infections - epidemiology Respiratory Tract Infections - virology reverse transcriptase polymerase chain reaction Sewage Sewage - virology Sewage disposal Viruses VP1 protein wastewater |
| title | Evidence of Saffold virus circulation in Italy provided through environmental surveillance |
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