Application of the adverse outcome pathway framework to genotoxic modes of action

In May 2017, the Health and Environmental Sciences Institute's Genetic Toxicology Technical Committee hosted a workshop to discuss whether mode of action (MOA) investigation is enhanced through the application of the adverse outcome pathway (AOP) framework. As AOPs are a relatively new approach...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2020-01, Vol.61 (1), p.114-134
Hauptverfasser:	Sasaki, Jennifer C., Allemang, Ashley, Bryce, Steven M., Custer, Laura, Dearfield, Kerry L., Dietz, Yasmin, Elhajouji, Azeddine, Escobar, Patricia A., Fornace, Albert J., Froetschl, Roland, Galloway, Sheila, Hemmann, Ulrike, Hendriks, Giel, Li, Heng‐Hong, Luijten, Mirjam, Ouedraogo, Gladys, Peel, Lauren, Pfuhler, Stefan, Roberts, Daniel J., Thybaud, Véronique, Benthem, Jan, Yauk, Carole L., Schuler, Maik
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse outcome pathway Aneuploidy Aurora kinase Case studies Cellular manufacture Chromosomes Deoxyribonucleic acid DNA DNA biosynthesis DNA topoisomerase (ATP-hydrolysing) Environmental science Genotoxicity Kinases Mode of action Mutation Reactive oxygen species Toxicity Toxicology Tubulin
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