Nystatin complexation with -cyclodextrin: Spectroscopic evaluation of inclusion by FT-Raman, photoacoustic spectroscopy, and 1H NMR
The inclusion complex of Nystatin (NYS) with β-cyclodextrin (β-CD) can increase the solubility of the antibiotic in aqueous media. The complexes were obtained by freeze-drying (FD) and spray-drying (SD) methods. The spectroscopic techniques used to analyze the complexes were FT-Raman, photoacoustic...
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| Veröffentlicht in: | Materials chemistry and physics 2020-01, Vol.239, p.1 |
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| creator | Somer, Aloisi Roik, João Ricardo Ribeiro, Mauricio Aparecido Urban, Amanda M Schoeffel, Amanda Urban, Vanessa M Farago, Paulo V de Castro, Lidiane Vizioli Sato, Francielle Jacinto, Carlos Campesatto, Eliane Moreira, Magna Suzana Alexandre Novatski, Andressa |
| description | The inclusion complex of Nystatin (NYS) with β-cyclodextrin (β-CD) can increase the solubility of the antibiotic in aqueous media. The complexes were obtained by freeze-drying (FD) and spray-drying (SD) methods. The spectroscopic techniques used to analyze the complexes were FT-Raman, photoacoustic spectroscopy (PAS), and 1H NMR. FT-Raman allowed the identification of the interactions of β-CD with NYS molecule through the vibrational modes assigned to tetraene, heptaene and C=O. PAS confirms that the main part of interaction from NYS is heptaene. The 1H NMR showed that the hydrogens inside the cavity of β-CD interact with NYS. These techniques confirmed the complex formation and that the drying method affects the form of complexation: by the FD method one molecule of β-CD is sufficient to form the complex with NYS. In contrast, the inclusion complex of NYS: β-CD by the SD method is formed by two molecules of β-CD. These results showed the effectiveness of these techniques in evaluating the inclusion complex and demonstrate that the drying method affects how this complexation occurs. |
| doi_str_mv | 10.1016/j.matchemphys.2019.122117 |
| format | Article |
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The complexes were obtained by freeze-drying (FD) and spray-drying (SD) methods. The spectroscopic techniques used to analyze the complexes were FT-Raman, photoacoustic spectroscopy (PAS), and 1H NMR. FT-Raman allowed the identification of the interactions of β-CD with NYS molecule through the vibrational modes assigned to tetraene, heptaene and C=O. PAS confirms that the main part of interaction from NYS is heptaene. The 1H NMR showed that the hydrogens inside the cavity of β-CD interact with NYS. These techniques confirmed the complex formation and that the drying method affects the form of complexation: by the FD method one molecule of β-CD is sufficient to form the complex with NYS. In contrast, the inclusion complex of NYS: β-CD by the SD method is formed by two molecules of β-CD. 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The complexes were obtained by freeze-drying (FD) and spray-drying (SD) methods. The spectroscopic techniques used to analyze the complexes were FT-Raman, photoacoustic spectroscopy (PAS), and 1H NMR. FT-Raman allowed the identification of the interactions of β-CD with NYS molecule through the vibrational modes assigned to tetraene, heptaene and C=O. PAS confirms that the main part of interaction from NYS is heptaene. The 1H NMR showed that the hydrogens inside the cavity of β-CD interact with NYS. These techniques confirmed the complex formation and that the drying method affects the form of complexation: by the FD method one molecule of β-CD is sufficient to form the complex with NYS. In contrast, the inclusion complex of NYS: β-CD by the SD method is formed by two molecules of β-CD. These results showed the effectiveness of these techniques in evaluating the inclusion complex and demonstrate that the drying method affects how this complexation occurs.</description><subject>Antibiotics</subject><subject>Aqueous solutions</subject><subject>Complex formation</subject><subject>Complexation</subject><subject>Cyclodextrins</subject><subject>Drying</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Photoacoustic spectroscopy</subject><subject>Spectrum analysis</subject><issn>0254-0584</issn><issn>1879-3312</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNjD9PwzAUxC0EEuHPd3iItQl-dkISVkTVhQ6le2VcV3GU-JnYgWbmixMEEivT3el-d4zdIM-Q4_1dm_Uq6sb0vplCJjjWGQqBWJ6wBKuyTqVEccoSLoo85UWVn7OLEFrOsUSUCftcTyGqaB1o6n1njrMnBx82NpDqSXe0N8c4WPcAL97oOFDQ5K0G86668QemA1inuzF8h9cJltt0o3rlFuAbiqQ0jSHOk_B3MC1AuT3gCtbPmyt2dlBdMNe_eslul0_bx1XqB3obTYi7lsbBzdVOSCnrvMCKy_9RXx0KXKY</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Somer, Aloisi</creator><creator>Roik, João Ricardo</creator><creator>Ribeiro, Mauricio Aparecido</creator><creator>Urban, Amanda M</creator><creator>Schoeffel, Amanda</creator><creator>Urban, Vanessa M</creator><creator>Farago, Paulo V</creator><creator>de Castro, Lidiane Vizioli</creator><creator>Sato, Francielle</creator><creator>Jacinto, Carlos</creator><creator>Campesatto, Eliane</creator><creator>Moreira, Magna Suzana Alexandre</creator><creator>Novatski, Andressa</creator><general>Elsevier BV</general><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20200101</creationdate><title>Nystatin complexation with -cyclodextrin: Spectroscopic evaluation of inclusion by FT-Raman, photoacoustic spectroscopy, and 1H NMR</title><author>Somer, Aloisi ; Roik, João Ricardo ; Ribeiro, Mauricio Aparecido ; Urban, Amanda M ; Schoeffel, Amanda ; Urban, Vanessa M ; Farago, Paulo V ; de Castro, Lidiane Vizioli ; Sato, Francielle ; Jacinto, Carlos ; Campesatto, Eliane ; Moreira, Magna Suzana Alexandre ; Novatski, Andressa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_23339451803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibiotics</topic><topic>Aqueous solutions</topic><topic>Complex formation</topic><topic>Complexation</topic><topic>Cyclodextrins</topic><topic>Drying</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Photoacoustic spectroscopy</topic><topic>Spectrum analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Somer, Aloisi</creatorcontrib><creatorcontrib>Roik, João Ricardo</creatorcontrib><creatorcontrib>Ribeiro, Mauricio Aparecido</creatorcontrib><creatorcontrib>Urban, Amanda M</creatorcontrib><creatorcontrib>Schoeffel, Amanda</creatorcontrib><creatorcontrib>Urban, Vanessa M</creatorcontrib><creatorcontrib>Farago, Paulo V</creatorcontrib><creatorcontrib>de Castro, Lidiane Vizioli</creatorcontrib><creatorcontrib>Sato, Francielle</creatorcontrib><creatorcontrib>Jacinto, Carlos</creatorcontrib><creatorcontrib>Campesatto, Eliane</creatorcontrib><creatorcontrib>Moreira, Magna Suzana Alexandre</creatorcontrib><creatorcontrib>Novatski, Andressa</creatorcontrib><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Materials chemistry and physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Somer, Aloisi</au><au>Roik, João Ricardo</au><au>Ribeiro, Mauricio Aparecido</au><au>Urban, Amanda M</au><au>Schoeffel, Amanda</au><au>Urban, Vanessa M</au><au>Farago, Paulo V</au><au>de Castro, Lidiane Vizioli</au><au>Sato, Francielle</au><au>Jacinto, Carlos</au><au>Campesatto, Eliane</au><au>Moreira, Magna Suzana Alexandre</au><au>Novatski, Andressa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nystatin complexation with -cyclodextrin: Spectroscopic evaluation of inclusion by FT-Raman, photoacoustic spectroscopy, and 1H NMR</atitle><jtitle>Materials chemistry and physics</jtitle><date>2020-01-01</date><risdate>2020</risdate><volume>239</volume><spage>1</spage><pages>1-</pages><issn>0254-0584</issn><eissn>1879-3312</eissn><abstract>The inclusion complex of Nystatin (NYS) with β-cyclodextrin (β-CD) can increase the solubility of the antibiotic in aqueous media. The complexes were obtained by freeze-drying (FD) and spray-drying (SD) methods. The spectroscopic techniques used to analyze the complexes were FT-Raman, photoacoustic spectroscopy (PAS), and 1H NMR. FT-Raman allowed the identification of the interactions of β-CD with NYS molecule through the vibrational modes assigned to tetraene, heptaene and C=O. PAS confirms that the main part of interaction from NYS is heptaene. The 1H NMR showed that the hydrogens inside the cavity of β-CD interact with NYS. These techniques confirmed the complex formation and that the drying method affects the form of complexation: by the FD method one molecule of β-CD is sufficient to form the complex with NYS. In contrast, the inclusion complex of NYS: β-CD by the SD method is formed by two molecules of β-CD. 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| subjects | Antibiotics Aqueous solutions Complex formation Complexation Cyclodextrins Drying NMR Nuclear magnetic resonance Photoacoustic spectroscopy Spectrum analysis |
| title | Nystatin complexation with -cyclodextrin: Spectroscopic evaluation of inclusion by FT-Raman, photoacoustic spectroscopy, and 1H NMR |
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