Acetaminophen sensitizing erastin‐induced ferroptosis via modulation of Nrf2/heme oxygenase‐1 signaling pathway in non‐small‐cell lung cancer

Growing evidence confirms that ferroptosis plays an important role in tumor growth inhibition. However, some non‐small‐cell lung cancer (NSCLC) cell lines are less sensitive to erastin‐induced ferroptotic cell death. Elucidating the mechanism of resistance of cancer cells to erastin‐induced ferropto...

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Veröffentlicht in:	Journal of cellular physiology 2020-04, Vol.235 (4), p.3329-3339
Hauptverfasser:	Gai, Chengcheng, Yu, Mengyu, Li, Zihaoran, Wang, Yonghong, Ding, Dejun, Zheng, Jie, Lv, Shijun, Zhang, Weifen, Li, Wentong
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetaminophen - pharmacology Analgesics Animals Apoptosis Apoptosis - drug effects Attenuation Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell death Cell Line, Tumor Cell Survival - drug effects Cell viability Drug Synergism erastin Ferroptosis Ferroptosis - drug effects Gene expression Gene Expression Regulation, Neoplastic - drug effects Glutathione Heme Heme Oxygenase-1 - genetics Humans Lipid Peroxides - metabolism Lipids Lung cancer Malondialdehyde Malondialdehyde - metabolism Mice NF-E2-Related Factor 2 - genetics Non-small cell lung carcinoma non‐small‐cell lung cancer Nrf2 NRF2 protein Nuclei (cytology) Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Oxygenase Peroxides Piperazines - pharmacology Reactive oxygen species Sensitizing Signal transduction Signal Transduction - drug effects Translocation Tumor cell lines Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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