Proflavine/acriflavine derivatives with versatile biological activities
Proflavine derivatives are extremely interesting chemotherapeutic agents, which have shown promising pharmaceutical potential due to their wide range of biological activities. This review summarizes the current state of research into the anticancer, antimicrobial, antimalarial and antileishmanial pr...
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| Veröffentlicht in: | Journal of applied toxicology 2020-01, Vol.40 (1), p.64-71 |
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| creator | Sabolova, Danica Kristian, Pavol Kozurkova, Mária |
| description | Proflavine derivatives are extremely interesting chemotherapeutic agents, which have shown promising pharmaceutical potential due to their wide range of biological activities. This review summarizes the current state of research into the anticancer, antimicrobial, antimalarial and antileishmanial properties of these attractive compounds. Our attention has focused on new classes of proflavine conjugates, which display significant levels of anticancer activity. Highly promising cytotoxic properties have been identified in proflavine conjugates with imidazolidinones, ureas and thioureas. In particular, proflavine‐dialkyldithioureas displayed substantial cytotoxic effect against the human leukemia HL‐60 cells with IC50 values from 7.2 to 34.0 μm. As well, palladium complexes with proflavine ligand have important biologic activity. The LC50 values of these complexes were significantly lower than that of cisplatin against the SK‐BR‐3 cell line.
Proflavine derivatives are extremely interesting chemotherapeutic agents, which have shown promising pharmaceutical potential due to their wide range of biological activities. This review summarizes the current state of research into the anticancer, antimicrobial, antimalarial and antileishmanial properties of these attractive compounds. |
| doi_str_mv | 10.1002/jat.3818 |
| format | Article |
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Proflavine derivatives are extremely interesting chemotherapeutic agents, which have shown promising pharmaceutical potential due to their wide range of biological activities. This review summarizes the current state of research into the anticancer, antimicrobial, antimalarial and antileishmanial properties of these attractive compounds.</description><subject>3,6‐diaminoacridine</subject><subject>3,6‐di‐substituted acridines</subject><subject>Acriflavine</subject><subject>Anticancer properties</subject><subject>Antimalarial agents</subject><subject>Antitumor activity</subject><subject>anti‐inflammatory</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Conjugates</subject><subject>Coordination compounds</subject><subject>Cytotoxicity</subject><subject>Derivatives</subject><subject>Leukemia</subject><subject>Palladium</subject><subject>proflavine</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kMFKw0AQhhdRbK2CTyABL17Szsw2yeZYilaloIcK3pZNstEtaVN3k5S-vVtbvXmaGebjH-Zj7BphiAA0WqpmyAWKE9ZHSNMQKeanrA8UQzjmyXuPXTi3BPA7Euesx5GIEgF9Nnu1dVmpzqz1SOXWHPug0NZ0qjGddsHWNJ9Bp63zc6WDzNRV_WFyVQUq94RpjHaX7KxUldNXxzpgbw_3i-ljOH-ZPU0n8zDngoswK7SgNEkBx0WWEma8RFQQU8SBBI8ynfAiQlJjiuK4LLEoUWsSCjED4DEfsNtD7sbWX612jVzWrV37k5I45xEkBMJTdwcqt7VzVpdyY81K2Z1EkHtj0huTe2MevTkGttlKF3_gryIPhAdg65_f_RsknyeLn8BvCCp0Ig</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Sabolova, Danica</creator><creator>Kristian, Pavol</creator><creator>Kozurkova, Mária</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>SOI</scope><orcidid>https://orcid.org/0000-0003-0942-0039</orcidid><orcidid>https://orcid.org/0000-0002-2789-8397</orcidid></search><sort><creationdate>202001</creationdate><title>Proflavine/acriflavine derivatives with versatile biological activities</title><author>Sabolova, Danica ; Kristian, Pavol ; Kozurkova, Mária</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3838-bde82979014db921b3f11a0625302835be73d512a42566ff1df1ee28a11b00363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>3,6‐diaminoacridine</topic><topic>3,6‐di‐substituted acridines</topic><topic>Acriflavine</topic><topic>Anticancer properties</topic><topic>Antimalarial agents</topic><topic>Antitumor activity</topic><topic>anti‐inflammatory</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Conjugates</topic><topic>Coordination compounds</topic><topic>Cytotoxicity</topic><topic>Derivatives</topic><topic>Leukemia</topic><topic>Palladium</topic><topic>proflavine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabolova, Danica</creatorcontrib><creatorcontrib>Kristian, Pavol</creatorcontrib><creatorcontrib>Kozurkova, Mária</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Environment Abstracts</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabolova, Danica</au><au>Kristian, Pavol</au><au>Kozurkova, Mária</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proflavine/acriflavine derivatives with versatile biological activities</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J Appl Toxicol</addtitle><date>2020-01</date><risdate>2020</risdate><volume>40</volume><issue>1</issue><spage>64</spage><epage>71</epage><pages>64-71</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><abstract>Proflavine derivatives are extremely interesting chemotherapeutic agents, which have shown promising pharmaceutical potential due to their wide range of biological activities. 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| subjects | 3,6‐diaminoacridine 3,6‐di‐substituted acridines Acriflavine Anticancer properties Antimalarial agents Antitumor activity anti‐inflammatory Cancer Chemotherapy Cisplatin Conjugates Coordination compounds Cytotoxicity Derivatives Leukemia Palladium proflavine |
| title | Proflavine/acriflavine derivatives with versatile biological activities |
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