Impact of low-dose anti-thymocyte globulin on immune reconstitution after allogeneic hematopoietic cell transplantation
How low-dose anti-thymocyte globulin (ATG) for prophylaxis of graft-versus-host disease (GVHD) influences immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HCT) remains incompletely understood. We prospectively enrolled 41 consecutive adult patients and conducted c...
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| Veröffentlicht in: | International journal of hematology 2020-01, Vol.111 (1), p.120-130 |
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| container_title | International journal of hematology |
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| creator | Ito, Ayumu Kitano, Shigehisa Tajima, Kinuko Kim, Youngji Tanaka, Takashi Inamoto, Yoshihiro Kim, Sung-Won Yamamoto, Noboru Fukuda, Takahiro Okamoto, Shinichiro |
| description | How low-dose anti-thymocyte globulin (ATG) for prophylaxis of graft-versus-host disease (GVHD) influences immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HCT) remains incompletely understood. We prospectively enrolled 41 consecutive adult patients and conducted cytometry-based immunophenotyping for 12 months after allo-HCT. Rabbit ATG (Thymoglobulin) was administered at a median total dose of 1.75 mg/kg in 16 of the 41 patients. Compared with patients who did not receive ATG, those who did had a significantly smaller number of naïve T cells (especially CD4+ ) within three months after allo-HCT. No significant difference was observed between the two groups in the reconstitution of other T cells (effector, memory, Th1, Th2, Th17, Treg, and Tfh), B cells (transitional, naïve, memory, and plasmablast), NK cells (regulatory and cytolytic), or dendritic cells (myeloid and plasmacytoid). Patients with fewer CD4+ naïve T cells than the median count (7.60 cells/µL) at two months after allo-HCT developed chronic GVHD less frequently than those with CD4+ naïve T cells above the median count (2-year cumulative incidences were 0.31 and 0.53, respectively;
p
= 0.133). This pilot study suggests low-dose Thymoglobulin suppresses the recovery of naïve T cells after allo-HCT, which may contribute to a lower incidence of chronic GVHD. |
| doi_str_mv | 10.1007/s12185-019-02756-1 |
| format | Article |
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p
= 0.133). This pilot study suggests low-dose Thymoglobulin suppresses the recovery of naïve T cells after allo-HCT, which may contribute to a lower incidence of chronic GVHD.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-019-02756-1</identifier><identifier>PMID: 31641956</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>CD4 antigen ; Cytometry ; Dendritic cells ; Effector cells ; Globulins ; Graft versus host disease ; Graft-versus-host reaction ; Helper cells ; Hematology ; Hematopoietic stem cells ; Immune reconstitution ; Immunological memory ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Medicine ; Medicine & Public Health ; Memory cells ; Oncology ; Original Article ; Prophylaxis ; Stem cell transplantation ; Stem cells ; Thymocytes ; Thymoglobulin ; Transplantation</subject><ispartof>International journal of hematology, 2020-01, Vol.111 (1), p.120-130</ispartof><rights>Japanese Society of Hematology 2019</rights><rights>International Journal of Hematology is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-b2d9676f32c2a10dbd3bfa5eb7b11af4cbf77f7f371532edc406450b2b7dd22f3</citedby><cites>FETCH-LOGICAL-c465t-b2d9676f32c2a10dbd3bfa5eb7b11af4cbf77f7f371532edc406450b2b7dd22f3</cites><orcidid>0000-0002-4041-8298</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-019-02756-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-019-02756-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31641956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ito, Ayumu</creatorcontrib><creatorcontrib>Kitano, Shigehisa</creatorcontrib><creatorcontrib>Tajima, Kinuko</creatorcontrib><creatorcontrib>Kim, Youngji</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Inamoto, Yoshihiro</creatorcontrib><creatorcontrib>Kim, Sung-Won</creatorcontrib><creatorcontrib>Yamamoto, Noboru</creatorcontrib><creatorcontrib>Fukuda, Takahiro</creatorcontrib><creatorcontrib>Okamoto, Shinichiro</creatorcontrib><title>Impact of low-dose anti-thymocyte globulin on immune reconstitution after allogeneic hematopoietic cell transplantation</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>How low-dose anti-thymocyte globulin (ATG) for prophylaxis of graft-versus-host disease (GVHD) influences immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HCT) remains incompletely understood. We prospectively enrolled 41 consecutive adult patients and conducted cytometry-based immunophenotyping for 12 months after allo-HCT. Rabbit ATG (Thymoglobulin) was administered at a median total dose of 1.75 mg/kg in 16 of the 41 patients. Compared with patients who did not receive ATG, those who did had a significantly smaller number of naïve T cells (especially CD4+ ) within three months after allo-HCT. No significant difference was observed between the two groups in the reconstitution of other T cells (effector, memory, Th1, Th2, Th17, Treg, and Tfh), B cells (transitional, naïve, memory, and plasmablast), NK cells (regulatory and cytolytic), or dendritic cells (myeloid and plasmacytoid). Patients with fewer CD4+ naïve T cells than the median count (7.60 cells/µL) at two months after allo-HCT developed chronic GVHD less frequently than those with CD4+ naïve T cells above the median count (2-year cumulative incidences were 0.31 and 0.53, respectively;
p
= 0.133). This pilot study suggests low-dose Thymoglobulin suppresses the recovery of naïve T cells after allo-HCT, which may contribute to a lower incidence of chronic GVHD.</description><subject>CD4 antigen</subject><subject>Cytometry</subject><subject>Dendritic cells</subject><subject>Effector cells</subject><subject>Globulins</subject><subject>Graft versus host disease</subject><subject>Graft-versus-host reaction</subject><subject>Helper cells</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Immune reconstitution</subject><subject>Immunological memory</subject><subject>Lymphocytes</subject><subject>Lymphocytes B</subject><subject>Lymphocytes T</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory cells</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prophylaxis</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Thymocytes</subject><subject>Thymoglobulin</subject><subject>Transplantation</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc2OFCEURonROO3oC7gwJG7coPwURdfSTEadZBI3uiZAXXqYUFAClUm_vbQ9auLCFQHO992bHIReM_qeUao-VMbZXhLKJkK5kiNhT9CO7UdJhFLDU7SjE5dEKkYv0Ita7yllig7qOboQbBzYJMcderhZVuMazh7H_EDmXAGb1AJpd8clu2MDfIjZbjEknBMOy7IlwAVcTrWFtrXQX41vULCJMR8gQXD4DhbT8poDtH5zECNuxaS6xt5tTpmX6Jk3scKrx_MSff90_e3qC7n9-vnm6uMtccMoG7F8nkY1esEdN4zOdhbWGwlWWcaMH5z1SnnlhWJScJjdQMdBUsutmmfOvbhE7869a8k_NqhNL6GeFjIJ8lY1F3TPOJ0G0dG3_6D3eSupb9cpIajilE-d4mfKlVxrAa_XEhZTjppRfdKiz1p016J_adGsh948Vm92gflP5LeHDogzUPtXOkD5O_s_tT8BfXibKg</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Ito, Ayumu</creator><creator>Kitano, Shigehisa</creator><creator>Tajima, Kinuko</creator><creator>Kim, Youngji</creator><creator>Tanaka, Takashi</creator><creator>Inamoto, Yoshihiro</creator><creator>Kim, Sung-Won</creator><creator>Yamamoto, Noboru</creator><creator>Fukuda, Takahiro</creator><creator>Okamoto, Shinichiro</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4041-8298</orcidid></search><sort><creationdate>20200101</creationdate><title>Impact of low-dose anti-thymocyte globulin on immune reconstitution after allogeneic hematopoietic cell transplantation</title><author>Ito, Ayumu ; Kitano, Shigehisa ; Tajima, Kinuko ; Kim, Youngji ; Tanaka, Takashi ; Inamoto, Yoshihiro ; Kim, Sung-Won ; Yamamoto, Noboru ; Fukuda, Takahiro ; Okamoto, Shinichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-b2d9676f32c2a10dbd3bfa5eb7b11af4cbf77f7f371532edc406450b2b7dd22f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>CD4 antigen</topic><topic>Cytometry</topic><topic>Dendritic cells</topic><topic>Effector cells</topic><topic>Globulins</topic><topic>Graft versus host disease</topic><topic>Graft-versus-host reaction</topic><topic>Helper cells</topic><topic>Hematology</topic><topic>Hematopoietic stem cells</topic><topic>Immune reconstitution</topic><topic>Immunological memory</topic><topic>Lymphocytes</topic><topic>Lymphocytes B</topic><topic>Lymphocytes T</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Memory cells</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prophylaxis</topic><topic>Stem cell transplantation</topic><topic>Stem cells</topic><topic>Thymocytes</topic><topic>Thymoglobulin</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Ayumu</creatorcontrib><creatorcontrib>Kitano, Shigehisa</creatorcontrib><creatorcontrib>Tajima, Kinuko</creatorcontrib><creatorcontrib>Kim, Youngji</creatorcontrib><creatorcontrib>Tanaka, Takashi</creatorcontrib><creatorcontrib>Inamoto, Yoshihiro</creatorcontrib><creatorcontrib>Kim, Sung-Won</creatorcontrib><creatorcontrib>Yamamoto, Noboru</creatorcontrib><creatorcontrib>Fukuda, Takahiro</creatorcontrib><creatorcontrib>Okamoto, Shinichiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Ayumu</au><au>Kitano, Shigehisa</au><au>Tajima, Kinuko</au><au>Kim, Youngji</au><au>Tanaka, Takashi</au><au>Inamoto, Yoshihiro</au><au>Kim, Sung-Won</au><au>Yamamoto, Noboru</au><au>Fukuda, Takahiro</au><au>Okamoto, Shinichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of low-dose anti-thymocyte globulin on immune reconstitution after allogeneic hematopoietic cell transplantation</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>111</volume><issue>1</issue><spage>120</spage><epage>130</epage><pages>120-130</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>How low-dose anti-thymocyte globulin (ATG) for prophylaxis of graft-versus-host disease (GVHD) influences immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HCT) remains incompletely understood. We prospectively enrolled 41 consecutive adult patients and conducted cytometry-based immunophenotyping for 12 months after allo-HCT. Rabbit ATG (Thymoglobulin) was administered at a median total dose of 1.75 mg/kg in 16 of the 41 patients. Compared with patients who did not receive ATG, those who did had a significantly smaller number of naïve T cells (especially CD4+ ) within three months after allo-HCT. No significant difference was observed between the two groups in the reconstitution of other T cells (effector, memory, Th1, Th2, Th17, Treg, and Tfh), B cells (transitional, naïve, memory, and plasmablast), NK cells (regulatory and cytolytic), or dendritic cells (myeloid and plasmacytoid). Patients with fewer CD4+ naïve T cells than the median count (7.60 cells/µL) at two months after allo-HCT developed chronic GVHD less frequently than those with CD4+ naïve T cells above the median count (2-year cumulative incidences were 0.31 and 0.53, respectively;
p
= 0.133). This pilot study suggests low-dose Thymoglobulin suppresses the recovery of naïve T cells after allo-HCT, which may contribute to a lower incidence of chronic GVHD.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>31641956</pmid><doi>10.1007/s12185-019-02756-1</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4041-8298</orcidid></addata></record> |
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| subjects | CD4 antigen Cytometry Dendritic cells Effector cells Globulins Graft versus host disease Graft-versus-host reaction Helper cells Hematology Hematopoietic stem cells Immune reconstitution Immunological memory Lymphocytes Lymphocytes B Lymphocytes T Medicine Medicine & Public Health Memory cells Oncology Original Article Prophylaxis Stem cell transplantation Stem cells Thymocytes Thymoglobulin Transplantation |
| title | Impact of low-dose anti-thymocyte globulin on immune reconstitution after allogeneic hematopoietic cell transplantation |
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