The Buckwheat Iminosugar d‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats
Scope This study examines the long‐term functional effects of d‐fagomine on sucrose‐induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35% sucrose solution with d‐fagomine (or not, for comparison) or...
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| Veröffentlicht in: | Molecular nutrition & food research 2020-01, Vol.64 (1), p.e1900564-n/a |
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| creator | Ramos‐Romero, Sara Hereu, Mercè Atienza, Lidia Amézqueta, Susana Casas, Josefina Muñoz, Silvia Medina, Isabel Miralles‐Pérez, Bernat Romeu, Marta Torres, Josep L. |
| description | Scope
This study examines the long‐term functional effects of d‐fagomine on sucrose‐induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action.
Methods and results
Wistar Kyoto rats are fed a 35% sucrose solution with d‐fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2‐IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d‐Fagomine reduces sucrose‐induced hypertension, urine uric acid and F2‐IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention.
Conclusion
d‐fagomine counteracts sucrose‐induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
The buckwheat iminosugar d‐fagomine reduces high‐sucrose‐induced hypertension, urine uric acid, and F2‐isoprostanes (markers of oxidative stress), steatosis, and liver diacylglicerols, without affecting perigonadal fat deposition. It is suggested that d‐fagomine counteracts sucrose‐induced steatosis and hypertension by reducing the postprandial levels of fructose in the liver. |
| doi_str_mv | 10.1002/mnfr.201900564 |
| format | Article |
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This study examines the long‐term functional effects of d‐fagomine on sucrose‐induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action.
Methods and results
Wistar Kyoto rats are fed a 35% sucrose solution with d‐fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2‐IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d‐Fagomine reduces sucrose‐induced hypertension, urine uric acid and F2‐IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention.
Conclusion
d‐fagomine counteracts sucrose‐induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
The buckwheat iminosugar d‐fagomine reduces high‐sucrose‐induced hypertension, urine uric acid, and F2‐isoprostanes (markers of oxidative stress), steatosis, and liver diacylglicerols, without affecting perigonadal fat deposition. It is suggested that d‐fagomine counteracts sucrose‐induced steatosis and hypertension by reducing the postprandial levels of fructose in the liver.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201900564</identifier><identifier>PMID: 31657510</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adipose tissue ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Animals ; Blood pressure ; Body weight ; Buckwheat ; Chemical compounds ; Deposition ; diabetes ; Diet ; Diglycerides - metabolism ; d‐fagomine ; E coli ; Energy intake ; Energy Intake - drug effects ; Fagopyrum - chemistry ; Fatty liver ; Fructose ; Gastrointestinal Microbiome - drug effects ; Glucose ; Glucose tolerance ; Histology ; Hypertension ; Hypertension - chemically induced ; Hypertension - drug therapy ; Imino Pyranoses - pharmacology ; Isoprostanes ; Isoprostanes - urine ; Leptin ; Leptin - blood ; Lipids ; Lipids - blood ; Liver ; Liver - drug effects ; Liver - metabolism ; Liver - pathology ; Male ; metabolic syndrome ; Mineral water ; Molecular modelling ; Non-alcoholic Fatty Liver Disease - chemically induced ; Non-alcoholic Fatty Liver Disease - drug therapy ; Oxidative stress ; Postprandial Period ; Rats, Inbred WKY ; Steatosis ; Sucrose ; Sucrose - toxicity ; Sugar ; Uric acid ; Uric Acid - blood ; Uric Acid - urine ; Urine</subject><ispartof>Molecular nutrition & food research, 2020-01, Vol.64 (1), p.e1900564-n/a</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2020 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4744-ddb712be8c77f8d8cb87577bbc1fdd9419f2a14464168a92478a810fa5c55fa73</citedby><cites>FETCH-LOGICAL-c4744-ddb712be8c77f8d8cb87577bbc1fdd9419f2a14464168a92478a810fa5c55fa73</cites><orcidid>0000-0002-9293-4454</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201900564$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201900564$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31657510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos‐Romero, Sara</creatorcontrib><creatorcontrib>Hereu, Mercè</creatorcontrib><creatorcontrib>Atienza, Lidia</creatorcontrib><creatorcontrib>Amézqueta, Susana</creatorcontrib><creatorcontrib>Casas, Josefina</creatorcontrib><creatorcontrib>Muñoz, Silvia</creatorcontrib><creatorcontrib>Medina, Isabel</creatorcontrib><creatorcontrib>Miralles‐Pérez, Bernat</creatorcontrib><creatorcontrib>Romeu, Marta</creatorcontrib><creatorcontrib>Torres, Josep L.</creatorcontrib><title>The Buckwheat Iminosugar d‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
This study examines the long‐term functional effects of d‐fagomine on sucrose‐induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action.
Methods and results
Wistar Kyoto rats are fed a 35% sucrose solution with d‐fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2‐IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d‐Fagomine reduces sucrose‐induced hypertension, urine uric acid and F2‐IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention.
Conclusion
d‐fagomine counteracts sucrose‐induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
The buckwheat iminosugar d‐fagomine reduces high‐sucrose‐induced hypertension, urine uric acid, and F2‐isoprostanes (markers of oxidative stress), steatosis, and liver diacylglicerols, without affecting perigonadal fat deposition. It is suggested that d‐fagomine counteracts sucrose‐induced steatosis and hypertension by reducing the postprandial levels of fructose in the liver.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Body weight</subject><subject>Buckwheat</subject><subject>Chemical compounds</subject><subject>Deposition</subject><subject>diabetes</subject><subject>Diet</subject><subject>Diglycerides - metabolism</subject><subject>d‐fagomine</subject><subject>E coli</subject><subject>Energy intake</subject><subject>Energy Intake - drug effects</subject><subject>Fagopyrum - chemistry</subject><subject>Fatty liver</subject><subject>Fructose</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Histology</subject><subject>Hypertension</subject><subject>Hypertension - chemically induced</subject><subject>Hypertension - drug therapy</subject><subject>Imino Pyranoses - pharmacology</subject><subject>Isoprostanes</subject><subject>Isoprostanes - urine</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>metabolic syndrome</subject><subject>Mineral water</subject><subject>Molecular modelling</subject><subject>Non-alcoholic Fatty Liver Disease - chemically induced</subject><subject>Non-alcoholic Fatty Liver Disease - drug therapy</subject><subject>Oxidative stress</subject><subject>Postprandial Period</subject><subject>Rats, Inbred WKY</subject><subject>Steatosis</subject><subject>Sucrose</subject><subject>Sucrose - toxicity</subject><subject>Sugar</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Uric Acid - urine</subject><subject>Urine</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFOAjEQhhujEUSvHk0Tz4udtrvdPSIRIUFNAM-b7raFRdjFdhvCzUfwGX0Sl4BcPc1k5vv_yfwI3QLpAiH0YV0a26UEEkLCiJ-hNkTAAg6MnZ96GrbQlXNLQhhQzi5Ri0EUihBIG-nZQuNHn39sF1rWeLQuysr5ubRY_Xx9D-S8aiYa9-pal17W2uGpz23ldLMdlcrnWuFp3UgrVzgsS4WHu422De2KqsRFiSeydtfowsiV0zfH2kHvg6dZfxiM355H_d44yLngPFAqE0AzHedCmFjFeRaLUIgsy8EolXBIDJXAecQhimVCuYhlDMTIMA9DIwXroPuD78ZWn167Ol1W3pbNyZQyBgKAUtJQ3QO1f8RZbdKNLdbS7lIg6T7VdJ9qekq1EdwdbX221uqE_8XYAPwAbIuV3v1jl768DiYsYpz9App6hZY</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Ramos‐Romero, Sara</creator><creator>Hereu, Mercè</creator><creator>Atienza, Lidia</creator><creator>Amézqueta, Susana</creator><creator>Casas, Josefina</creator><creator>Muñoz, Silvia</creator><creator>Medina, Isabel</creator><creator>Miralles‐Pérez, Bernat</creator><creator>Romeu, Marta</creator><creator>Torres, Josep L.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-9293-4454</orcidid></search><sort><creationdate>202001</creationdate><title>The Buckwheat Iminosugar d‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats</title><author>Ramos‐Romero, Sara ; Hereu, Mercè ; Atienza, Lidia ; Amézqueta, Susana ; Casas, Josefina ; Muñoz, Silvia ; Medina, Isabel ; Miralles‐Pérez, Bernat ; Romeu, Marta ; Torres, Josep L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4744-ddb712be8c77f8d8cb87577bbc1fdd9419f2a14464168a92478a810fa5c55fa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Blood pressure</topic><topic>Body weight</topic><topic>Buckwheat</topic><topic>Chemical compounds</topic><topic>Deposition</topic><topic>diabetes</topic><topic>Diet</topic><topic>Diglycerides - metabolism</topic><topic>d‐fagomine</topic><topic>E coli</topic><topic>Energy intake</topic><topic>Energy Intake - drug effects</topic><topic>Fagopyrum - chemistry</topic><topic>Fatty liver</topic><topic>Fructose</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Histology</topic><topic>Hypertension</topic><topic>Hypertension - chemically induced</topic><topic>Hypertension - drug therapy</topic><topic>Imino Pyranoses - pharmacology</topic><topic>Isoprostanes</topic><topic>Isoprostanes - urine</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>metabolic syndrome</topic><topic>Mineral water</topic><topic>Molecular modelling</topic><topic>Non-alcoholic Fatty Liver Disease - chemically induced</topic><topic>Non-alcoholic Fatty Liver Disease - drug therapy</topic><topic>Oxidative stress</topic><topic>Postprandial Period</topic><topic>Rats, Inbred WKY</topic><topic>Steatosis</topic><topic>Sucrose</topic><topic>Sucrose - toxicity</topic><topic>Sugar</topic><topic>Uric acid</topic><topic>Uric Acid - blood</topic><topic>Uric Acid - urine</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos‐Romero, Sara</creatorcontrib><creatorcontrib>Hereu, Mercè</creatorcontrib><creatorcontrib>Atienza, Lidia</creatorcontrib><creatorcontrib>Amézqueta, Susana</creatorcontrib><creatorcontrib>Casas, Josefina</creatorcontrib><creatorcontrib>Muñoz, Silvia</creatorcontrib><creatorcontrib>Medina, Isabel</creatorcontrib><creatorcontrib>Miralles‐Pérez, Bernat</creatorcontrib><creatorcontrib>Romeu, Marta</creatorcontrib><creatorcontrib>Torres, Josep L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos‐Romero, Sara</au><au>Hereu, Mercè</au><au>Atienza, Lidia</au><au>Amézqueta, Susana</au><au>Casas, Josefina</au><au>Muñoz, Silvia</au><au>Medina, Isabel</au><au>Miralles‐Pérez, Bernat</au><au>Romeu, Marta</au><au>Torres, Josep L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Buckwheat Iminosugar d‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2020-01</date><risdate>2020</risdate><volume>64</volume><issue>1</issue><spage>e1900564</spage><epage>n/a</epage><pages>e1900564-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope
This study examines the long‐term functional effects of d‐fagomine on sucrose‐induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action.
Methods and results
Wistar Kyoto rats are fed a 35% sucrose solution with d‐fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2‐IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d‐Fagomine reduces sucrose‐induced hypertension, urine uric acid and F2‐IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention.
Conclusion
d‐fagomine counteracts sucrose‐induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
The buckwheat iminosugar d‐fagomine reduces high‐sucrose‐induced hypertension, urine uric acid, and F2‐isoprostanes (markers of oxidative stress), steatosis, and liver diacylglicerols, without affecting perigonadal fat deposition. It is suggested that d‐fagomine counteracts sucrose‐induced steatosis and hypertension by reducing the postprandial levels of fructose in the liver.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31657510</pmid><doi>10.1002/mnfr.201900564</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9293-4454</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Blood pressure Body weight Buckwheat Chemical compounds Deposition diabetes Diet Diglycerides - metabolism d‐fagomine E coli Energy intake Energy Intake - drug effects Fagopyrum - chemistry Fatty liver Fructose Gastrointestinal Microbiome - drug effects Glucose Glucose tolerance Histology Hypertension Hypertension - chemically induced Hypertension - drug therapy Imino Pyranoses - pharmacology Isoprostanes Isoprostanes - urine Leptin Leptin - blood Lipids Lipids - blood Liver Liver - drug effects Liver - metabolism Liver - pathology Male metabolic syndrome Mineral water Molecular modelling Non-alcoholic Fatty Liver Disease - chemically induced Non-alcoholic Fatty Liver Disease - drug therapy Oxidative stress Postprandial Period Rats, Inbred WKY Steatosis Sucrose Sucrose - toxicity Sugar Uric acid Uric Acid - blood Uric Acid - urine Urine |
| title | The Buckwheat Iminosugar d‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats |
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