Abrogation of protein phosphatase 6 promotes skin carcinogenesis induced by DMBA

Somatic mutations in the gene encoding the catalytic subunit of protein phosphatase 6 ( Ppp6c ) have been identified in malignant melanoma and are thought to function as a driver in B-raf- or N-ras-driven tumorigenesis. To assess the role of Ppp6c in carcinogenesis, we generated skin keratinocyte-sp...

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Veröffentlicht in:	Oncogene 2015-08, Vol.34 (35), p.4647-4655
Hauptverfasser:	Hayashi, K, Momoi, Y, Tanuma, N, Kishimoto, A, Ogoh, H, Kato, H, Suzuki, M, Sakamoto, Y, Inoue, Y, Nomura, M, Kiyonari, H, Sakayori, M, Fukamachi, K, Kakugawa, Y, Yamashita, Y, Ito, S, Sato, I, Suzuki, A, Nishio, M, Suganuma, M, Watanabe, T, Shima, H
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/63 45/41 631/67/581 64/60 9,10-Dimethyl-1,2-benzanthracene 96/1 Acetic acid Animals Anthracene Apoptosis Carcinogenesis Carcinogenesis - metabolism Cell Biology Cells, Cultured Gene mutations Human Genetics Internal Medicine Keratinocytes Keratinocytes - enzymology Medicine Medicine & Public Health Melanoma Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Mutation NF-kappa B - metabolism NF-κB protein Oncology original-article Papilloma Phosphatase Phosphatases Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - metabolism Protein phosphatase Proteins Raf protein Rodents Signal Transduction Skin Skin - enzymology Skin - pathology Skin cancer Skin Neoplasms - chemically induced Skin Neoplasms - enzymology Studies Tumor necrosis factor-TNF Tumor necrosis factor-α Tumorigenesis
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