Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth
Objective: Procyanidins are polyphenolic bioactive compounds that exert beneficial effects against obesity and its related diseases. The aim of this study was to evaluate whether supplementation with low doses of a grape seed procyanidin extract (GSPE) to rats during pre- and postnatal periods provi...
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| Veröffentlicht in: | International Journal of Obesity 2015-01, Vol.39 (1), p.7-15 |
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| creator | del Bas, J M Crescenti, A Arola-Arnal, A Oms-Oliu, G Arola, L Caimari, A |
| description | Objective:
Procyanidins are polyphenolic bioactive compounds that exert beneficial effects against obesity and its related diseases. The aim of this study was to evaluate whether supplementation with low doses of a grape seed procyanidin extract (GSPE) to rats during pre- and postnatal periods provides biological effects to their offspring in youth.
Design:
The metabolic programming effect of GSPE was evaluated in the 30-day-old male offspring of four groups of rats that were fed either a standard diet (STD) or a high-fat diet (HFD) and that were supplemented with either GSPE (25 mg kg
−1
of body weight per day) or vehicle during pregnancy and lactation.
Results:
Significant increases in the adiposity index and in the weights of all the white adipose tissue depots studied (retroperitoneal, mesenteric, epididymal (EWAT) and inguinal) were observed in the offspring of rats that were fed a HFD and that were treated with GSPE (HFD-GSPE group) compared with the offspring of rats that were fed the same diet but that did not receive the procyanidins (HFD group). The HFD-GSPE animals also exhibited a higher number of cells in the EWAT, a sharp decrease in the circulating levels of monocyte chemoattractant protein-1 (MCP-1) and a moderate decrease in the plasma glycerol levels. The transcriptomic analysis performed in the EWAT showed 238 genes that were differentially expressed between the HFD and the HFD-GSPE animals, most of which were associated with the immune function and the inflammatory response, in addition to genes associated with adipose tissue remodeling and function, lipid and glucose homeostasis and the metabolism of methyl groups.
Conclusion:
The GSPE treatment in rats that were fed an HFD during pregnancy and lactation induced a clear metabolic programming effect in the offspring, increasing adiposity, decreasing the circulating levels of MCP-1 and changing the gene expression in the EWAT toward a better inflammatory profile. |
| doi_str_mv | 10.1038/ijo.2014.159 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2331622784</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A397455340</galeid><sourcerecordid>A397455340</sourcerecordid><originalsourceid>FETCH-LOGICAL-c622t-bcc9a290ccfac6abd102386c5a76fca02f593e05acbd7811a10c278707f214813</originalsourceid><addsrcrecordid>eNqFkk2L1TAUhosozji6cy0BwZW9JmnTtMvLoKMw4EbX5TQ9uc2lTWqSLvqT51-Y-6FeYVACST-e9yTnzZtlrxndMFrUH8zebThl5YaJ5kl2zUpZ5aJs5NPsmhZU5lRU4ip7EcKeUioE5c-zKy6Y4Lyk19nDnYcZSUDsyeydWsGa3lgSlnkecUIbIRpnSXTEQwxEJw7IYHZDriGS3mCaFm_sLslxZ8GqlYDtyQjqLDVWeYSAgcQBSef6lRykytmYyh_hyfXLCPGMGKtHmCaIzq_EY5idDXjkDn-hN7NL79GEsCCZMELnRhMm4vQRmGDE9KzDfDxWamZ1SxxeZs80jAFfndeb7Punj99uP-f3X---3G7vc1VxHvNOqQZ4Q5XSoCroekZ5UVdKgKy0Asq1aAqkAlTXy5oxYFRxWUsqNWdlzYqb7O2pbrLzx4Ihtnu3eJu2bHlRsLSJrMt_UawqOatlwas_1C711CZfXPSgJhNUuy0aWQpRlDRRm0eoNHqcTLIZtUnf_xK8uxAMCGMcghuXw3WFdlsxypqGSfk_8LLi-xOovAvBo26T-RP4tWW0PcS0TTFtDzFtU0wT_ubc_dJN2P-Gf-UyAfkJOF0i-gt7Hiv4E2RA9FQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1642187326</pqid></control><display><type>article</type><title>Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth</title><source>MEDLINE</source><source>Nature</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>del Bas, J M ; Crescenti, A ; Arola-Arnal, A ; Oms-Oliu, G ; Arola, L ; Caimari, A</creator><creatorcontrib>del Bas, J M ; Crescenti, A ; Arola-Arnal, A ; Oms-Oliu, G ; Arola, L ; Caimari, A</creatorcontrib><description>Objective:
Procyanidins are polyphenolic bioactive compounds that exert beneficial effects against obesity and its related diseases. The aim of this study was to evaluate whether supplementation with low doses of a grape seed procyanidin extract (GSPE) to rats during pre- and postnatal periods provides biological effects to their offspring in youth.
Design:
The metabolic programming effect of GSPE was evaluated in the 30-day-old male offspring of four groups of rats that were fed either a standard diet (STD) or a high-fat diet (HFD) and that were supplemented with either GSPE (25 mg kg
−1
of body weight per day) or vehicle during pregnancy and lactation.
Results:
Significant increases in the adiposity index and in the weights of all the white adipose tissue depots studied (retroperitoneal, mesenteric, epididymal (EWAT) and inguinal) were observed in the offspring of rats that were fed a HFD and that were treated with GSPE (HFD-GSPE group) compared with the offspring of rats that were fed the same diet but that did not receive the procyanidins (HFD group). The HFD-GSPE animals also exhibited a higher number of cells in the EWAT, a sharp decrease in the circulating levels of monocyte chemoattractant protein-1 (MCP-1) and a moderate decrease in the plasma glycerol levels. The transcriptomic analysis performed in the EWAT showed 238 genes that were differentially expressed between the HFD and the HFD-GSPE animals, most of which were associated with the immune function and the inflammatory response, in addition to genes associated with adipose tissue remodeling and function, lipid and glucose homeostasis and the metabolism of methyl groups.
Conclusion:
The GSPE treatment in rats that were fed an HFD during pregnancy and lactation induced a clear metabolic programming effect in the offspring, increasing adiposity, decreasing the circulating levels of MCP-1 and changing the gene expression in the EWAT toward a better inflammatory profile.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2014.159</identifier><identifier>PMID: 25152240</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250/256 ; 631/443/319/2723 ; 692/699/2743/393 ; 692/700/459/1994 ; Adipose tissue ; Adipose Tissue - drug effects ; Adipose Tissue - immunology ; Adipose tissues ; Animals ; Animals, Newborn ; Antioxidants - pharmacology ; Biflavonoids - pharmacology ; Bioactive compounds ; Biological effects ; Body fat ; Body Weight ; Breastfeeding & lactation ; Catechin - pharmacology ; Diet ; Diet, High-Fat ; Dietary supplements ; DNA methylation ; Epidemiology ; Female ; Fetuses ; Flavonoids ; Fuel consumption ; Gene expression ; Genes ; Genetic aspects ; Genetic research ; Glucose metabolism ; Glycerol ; Grape Seed Extract - pharmacology ; Grapes ; Health aspects ; Health Promotion and Disease Prevention ; High fat diet ; Homeostasis ; Hypertension ; Immune response ; Immune response regulation ; Inflammation ; Inflammation - prevention & control ; Inflammatory response ; Insulin resistance ; Internal Medicine ; Lactation ; Lactation - drug effects ; Lactation - immunology ; Lipid Metabolism ; Lipids ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolism ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Nutrition research ; Obesity ; Offspring ; pediatric-original-article ; Physiological aspects ; Plant Extracts - pharmacology ; Polyphenols ; Pregnancy ; Prenatal influences ; Proanthocyanidins - pharmacology ; Procyanidins ; Properties ; Public Health ; Rats ; Tumor necrosis factor-TNF</subject><ispartof>International Journal of Obesity, 2015-01, Vol.39 (1), p.7-15</ispartof><rights>Macmillan Publishers Limited 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-bcc9a290ccfac6abd102386c5a76fca02f593e05acbd7811a10c278707f214813</citedby><cites>FETCH-LOGICAL-c622t-bcc9a290ccfac6abd102386c5a76fca02f593e05acbd7811a10c278707f214813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2014.159$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2014.159$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25152240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>del Bas, J M</creatorcontrib><creatorcontrib>Crescenti, A</creatorcontrib><creatorcontrib>Arola-Arnal, A</creatorcontrib><creatorcontrib>Oms-Oliu, G</creatorcontrib><creatorcontrib>Arola, L</creatorcontrib><creatorcontrib>Caimari, A</creatorcontrib><title>Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Objective:
Procyanidins are polyphenolic bioactive compounds that exert beneficial effects against obesity and its related diseases. The aim of this study was to evaluate whether supplementation with low doses of a grape seed procyanidin extract (GSPE) to rats during pre- and postnatal periods provides biological effects to their offspring in youth.
Design:
The metabolic programming effect of GSPE was evaluated in the 30-day-old male offspring of four groups of rats that were fed either a standard diet (STD) or a high-fat diet (HFD) and that were supplemented with either GSPE (25 mg kg
−1
of body weight per day) or vehicle during pregnancy and lactation.
Results:
Significant increases in the adiposity index and in the weights of all the white adipose tissue depots studied (retroperitoneal, mesenteric, epididymal (EWAT) and inguinal) were observed in the offspring of rats that were fed a HFD and that were treated with GSPE (HFD-GSPE group) compared with the offspring of rats that were fed the same diet but that did not receive the procyanidins (HFD group). The HFD-GSPE animals also exhibited a higher number of cells in the EWAT, a sharp decrease in the circulating levels of monocyte chemoattractant protein-1 (MCP-1) and a moderate decrease in the plasma glycerol levels. The transcriptomic analysis performed in the EWAT showed 238 genes that were differentially expressed between the HFD and the HFD-GSPE animals, most of which were associated with the immune function and the inflammatory response, in addition to genes associated with adipose tissue remodeling and function, lipid and glucose homeostasis and the metabolism of methyl groups.
Conclusion:
The GSPE treatment in rats that were fed an HFD during pregnancy and lactation induced a clear metabolic programming effect in the offspring, increasing adiposity, decreasing the circulating levels of MCP-1 and changing the gene expression in the EWAT toward a better inflammatory profile.</description><subject>631/250/256</subject><subject>631/443/319/2723</subject><subject>692/699/2743/393</subject><subject>692/700/459/1994</subject><subject>Adipose tissue</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - immunology</subject><subject>Adipose tissues</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Antioxidants - pharmacology</subject><subject>Biflavonoids - pharmacology</subject><subject>Bioactive compounds</subject><subject>Biological effects</subject><subject>Body fat</subject><subject>Body Weight</subject><subject>Breastfeeding & lactation</subject><subject>Catechin - pharmacology</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Dietary supplements</subject><subject>DNA methylation</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fetuses</subject><subject>Flavonoids</subject><subject>Fuel consumption</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Glucose metabolism</subject><subject>Glycerol</subject><subject>Grape Seed Extract - pharmacology</subject><subject>Grapes</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>High fat diet</subject><subject>Homeostasis</subject><subject>Hypertension</subject><subject>Immune response</subject><subject>Immune response regulation</subject><subject>Inflammation</subject><subject>Inflammation - prevention & control</subject><subject>Inflammatory response</subject><subject>Insulin resistance</subject><subject>Internal Medicine</subject><subject>Lactation</subject><subject>Lactation - drug effects</subject><subject>Lactation - immunology</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolism</subject><subject>Monocyte chemoattractant protein</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Monocytes</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>Offspring</subject><subject>pediatric-original-article</subject><subject>Physiological aspects</subject><subject>Plant Extracts - pharmacology</subject><subject>Polyphenols</subject><subject>Pregnancy</subject><subject>Prenatal influences</subject><subject>Proanthocyanidins - pharmacology</subject><subject>Procyanidins</subject><subject>Properties</subject><subject>Public Health</subject><subject>Rats</subject><subject>Tumor necrosis factor-TNF</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkk2L1TAUhosozji6cy0BwZW9JmnTtMvLoKMw4EbX5TQ9uc2lTWqSLvqT51-Y-6FeYVACST-e9yTnzZtlrxndMFrUH8zebThl5YaJ5kl2zUpZ5aJs5NPsmhZU5lRU4ip7EcKeUioE5c-zKy6Y4Lyk19nDnYcZSUDsyeydWsGa3lgSlnkecUIbIRpnSXTEQwxEJw7IYHZDriGS3mCaFm_sLslxZ8GqlYDtyQjqLDVWeYSAgcQBSef6lRykytmYyh_hyfXLCPGMGKtHmCaIzq_EY5idDXjkDn-hN7NL79GEsCCZMELnRhMm4vQRmGDE9KzDfDxWamZ1SxxeZs80jAFfndeb7Punj99uP-f3X---3G7vc1VxHvNOqQZ4Q5XSoCroekZ5UVdKgKy0Asq1aAqkAlTXy5oxYFRxWUsqNWdlzYqb7O2pbrLzx4Ihtnu3eJu2bHlRsLSJrMt_UawqOatlwas_1C711CZfXPSgJhNUuy0aWQpRlDRRm0eoNHqcTLIZtUnf_xK8uxAMCGMcghuXw3WFdlsxypqGSfk_8LLi-xOovAvBo26T-RP4tWW0PcS0TTFtDzFtU0wT_ubc_dJN2P-Gf-UyAfkJOF0i-gt7Hiv4E2RA9FQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>del Bas, J M</creator><creator>Crescenti, A</creator><creator>Arola-Arnal, A</creator><creator>Oms-Oliu, G</creator><creator>Arola, L</creator><creator>Caimari, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20150101</creationdate><title>Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth</title><author>del Bas, J M ; Crescenti, A ; Arola-Arnal, A ; Oms-Oliu, G ; Arola, L ; Caimari, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-bcc9a290ccfac6abd102386c5a76fca02f593e05acbd7811a10c278707f214813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/250/256</topic><topic>631/443/319/2723</topic><topic>692/699/2743/393</topic><topic>692/700/459/1994</topic><topic>Adipose tissue</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - immunology</topic><topic>Adipose tissues</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antioxidants - pharmacology</topic><topic>Biflavonoids - pharmacology</topic><topic>Bioactive compounds</topic><topic>Biological effects</topic><topic>Body fat</topic><topic>Body Weight</topic><topic>Breastfeeding & lactation</topic><topic>Catechin - pharmacology</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Dietary supplements</topic><topic>DNA methylation</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fetuses</topic><topic>Flavonoids</topic><topic>Fuel consumption</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Glucose metabolism</topic><topic>Glycerol</topic><topic>Grape Seed Extract - pharmacology</topic><topic>Grapes</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>High fat diet</topic><topic>Homeostasis</topic><topic>Hypertension</topic><topic>Immune response</topic><topic>Immune response regulation</topic><topic>Inflammation</topic><topic>Inflammation - prevention & control</topic><topic>Inflammatory response</topic><topic>Insulin resistance</topic><topic>Internal Medicine</topic><topic>Lactation</topic><topic>Lactation - drug effects</topic><topic>Lactation - immunology</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolism</topic><topic>Monocyte chemoattractant protein</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Monocytes</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>Offspring</topic><topic>pediatric-original-article</topic><topic>Physiological aspects</topic><topic>Plant Extracts - pharmacology</topic><topic>Polyphenols</topic><topic>Pregnancy</topic><topic>Prenatal influences</topic><topic>Proanthocyanidins - pharmacology</topic><topic>Procyanidins</topic><topic>Properties</topic><topic>Public Health</topic><topic>Rats</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>del Bas, J M</creatorcontrib><creatorcontrib>Crescenti, A</creatorcontrib><creatorcontrib>Arola-Arnal, A</creatorcontrib><creatorcontrib>Oms-Oliu, G</creatorcontrib><creatorcontrib>Arola, L</creatorcontrib><creatorcontrib>Caimari, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>del Bas, J M</au><au>Crescenti, A</au><au>Arola-Arnal, A</au><au>Oms-Oliu, G</au><au>Arola, L</au><au>Caimari, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>39</volume><issue>1</issue><spage>7</spage><epage>15</epage><pages>7-15</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Objective:
Procyanidins are polyphenolic bioactive compounds that exert beneficial effects against obesity and its related diseases. The aim of this study was to evaluate whether supplementation with low doses of a grape seed procyanidin extract (GSPE) to rats during pre- and postnatal periods provides biological effects to their offspring in youth.
Design:
The metabolic programming effect of GSPE was evaluated in the 30-day-old male offspring of four groups of rats that were fed either a standard diet (STD) or a high-fat diet (HFD) and that were supplemented with either GSPE (25 mg kg
−1
of body weight per day) or vehicle during pregnancy and lactation.
Results:
Significant increases in the adiposity index and in the weights of all the white adipose tissue depots studied (retroperitoneal, mesenteric, epididymal (EWAT) and inguinal) were observed in the offspring of rats that were fed a HFD and that were treated with GSPE (HFD-GSPE group) compared with the offspring of rats that were fed the same diet but that did not receive the procyanidins (HFD group). The HFD-GSPE animals also exhibited a higher number of cells in the EWAT, a sharp decrease in the circulating levels of monocyte chemoattractant protein-1 (MCP-1) and a moderate decrease in the plasma glycerol levels. The transcriptomic analysis performed in the EWAT showed 238 genes that were differentially expressed between the HFD and the HFD-GSPE animals, most of which were associated with the immune function and the inflammatory response, in addition to genes associated with adipose tissue remodeling and function, lipid and glucose homeostasis and the metabolism of methyl groups.
Conclusion:
The GSPE treatment in rats that were fed an HFD during pregnancy and lactation induced a clear metabolic programming effect in the offspring, increasing adiposity, decreasing the circulating levels of MCP-1 and changing the gene expression in the EWAT toward a better inflammatory profile.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25152240</pmid><doi>10.1038/ijo.2014.159</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2015-01, Vol.39 (1), p.7-15 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_proquest_journals_2331622784 |
| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 631/250/256 631/443/319/2723 692/699/2743/393 692/700/459/1994 Adipose tissue Adipose Tissue - drug effects Adipose Tissue - immunology Adipose tissues Animals Animals, Newborn Antioxidants - pharmacology Biflavonoids - pharmacology Bioactive compounds Biological effects Body fat Body Weight Breastfeeding & lactation Catechin - pharmacology Diet Diet, High-Fat Dietary supplements DNA methylation Epidemiology Female Fetuses Flavonoids Fuel consumption Gene expression Genes Genetic aspects Genetic research Glucose metabolism Glycerol Grape Seed Extract - pharmacology Grapes Health aspects Health Promotion and Disease Prevention High fat diet Homeostasis Hypertension Immune response Immune response regulation Inflammation Inflammation - prevention & control Inflammatory response Insulin resistance Internal Medicine Lactation Lactation - drug effects Lactation - immunology Lipid Metabolism Lipids Male Medicine Medicine & Public Health Metabolic Diseases Metabolism Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Monocytes Nutrition research Obesity Offspring pediatric-original-article Physiological aspects Plant Extracts - pharmacology Polyphenols Pregnancy Prenatal influences Proanthocyanidins - pharmacology Procyanidins Properties Public Health Rats Tumor necrosis factor-TNF |
| title | Grape seed procyanidin supplementation to rats fed a high-fat diet during pregnancy and lactation increases the body fat content and modulates the inflammatory response and the adipose tissue metabolism of the male offspring in youth |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T07%3A38%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Grape%20seed%20procyanidin%20supplementation%20to%20rats%20fed%20a%20high-fat%20diet%20during%20pregnancy%20and%20lactation%20increases%20the%20body%20fat%20content%20and%20modulates%20the%20inflammatory%20response%20and%20the%20adipose%20tissue%20metabolism%20of%20the%20male%20offspring%20in%20youth&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=del%20Bas,%20J%20M&rft.date=2015-01-01&rft.volume=39&rft.issue=1&rft.spage=7&rft.epage=15&rft.pages=7-15&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/ijo.2014.159&rft_dat=%3Cgale_proqu%3EA397455340%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1642187326&rft_id=info:pmid/25152240&rft_galeid=A397455340&rfr_iscdi=true |