Cabazitaxel versus Abiraterone or Enzalutamide in Metastatic Prostate Cancer

A randomized trial involving patients with metastatic prostate cancer whose disease progressed after receipt of docetaxel and hormonal therapy showed that cabazitaxel was superior to an androgen-signaling–targeted agent in extending imaging-based progression-free survival, overall survival, and PSA...

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Veröffentlicht in:	The New England journal of medicine 2019-12, Vol.381 (26), p.2506-2518
Hauptverfasser:	de Wit, Ronald, de Bono, Johann, Sternberg, Cora N, Fizazi, Karim, Tombal, Bertrand, Wülfing, Christian, Kramer, Gero, Eymard, Jean-Christophe, Bamias, Aristotelis, Carles, Joan, Iacovelli, Roberto, Melichar, Bohuslav, Sverrisdóttir, Ásgerður, Theodore, Christine, Feyerabend, Susan, Helissey, Carole, Ozatilgan, Ayse, Geffriaud-Ricouard, Christine, Castellano, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analgesics Androgen Antagonists - administration & dosage Androgen Antagonists - adverse effects Androgens Androstenes - administration & dosage Androstenes - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer therapies Castration Colony-stimulating factor Death Granulocyte colony-stimulating factor Humans Infusions, Intravenous Kaplan-Meier Estimate Leukocytes (granulocytic) Male Metastases Metastasis Middle Aged Pain Patients Phenylthiohydantoin - administration & dosage Phenylthiohydantoin - adverse effects Phenylthiohydantoin - analogs & derivatives Prednisone Prednisone - administration & dosage Progression-Free Survival Prostate cancer Prostate-specific antigen Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - mortality Safety Survival Taxoids - administration & dosage Taxoids - adverse effects Working groups
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