Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells

The toxicity of some per- and polyfluoroalkyl substances (PFASs), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been studied thoroughly, showing that systemic PFASs targets the lungs. However, regulators lack data to assess the impact of other PFASs on the lungs and...

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Veröffentlicht in:	Toxicology in vitro 2020-02, Vol.62, p.104656, Article 104656
Hauptverfasser:	Sørli, Jorid B., Låg, Marit, Ekeren, Leni, Perez-Gil, Jesus, Haug, Line S., Da Silva, Emilie, Matrod, Muhammad N., Gützkow, Kristine B., Lindeman, Birgitte
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute inhalation toxicity Alkanesulfonic Acids - toxicity Alternative methods Bronchi - cytology Bronchial epithelial cells Caprylates - toxicity Cell Line Cell Survival - drug effects Chemokines Constrained drop surfactometer CXCL10 protein Cytokines - metabolism Epithelial cells Fluorocarbons - toxicity Human behavior Humans IL-1β Inflammation Inflammatory response Inhalation Lung surfactant Lungs Perfluoro compounds Perfluorohexane Perfluorooctanoic acid Pro-inflammatory responses Pulmonary Surfactants - metabolism Regulators Respiration Respiratory system Salts Surfactants Toxicity Toxicity testing
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