Normal development of mice lacking PAXX , the paralogue of XRCC 4 and XLF

DNA repair consists of several cellular pathways which recognize and repair damaged DNA . The classical nonhomologous DNA end‐joining ( NHEJ ) pathway repairs double‐strand breaks in DNA . It is required for maturation of both B and T lymphocytes by supporting V(D)J recombination as well as B‐cell d...

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Veröffentlicht in:	FEBS open bio 2018-03, Vol.8 (3), p.426-434
Hauptverfasser:	Gago‐Fuentes, Raquel, Xing, Mengtan, Sæterstad, Siri, Sarno, Antonio, Dewan, Alisa, Beck, Carole, Bradamante, Stefano, Bjørås, Magnar, Oksenych, Valentyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone marrow Cell differentiation Class switching Deoxyribonucleic acid DNA DNA damage DNA repair Exons Immunoglobulins Ionizing radiation Kinases Lymphocytes Lymphocytes B Lymphocytes T Non-homologous end joining Rodents Severe combined immunodeficiency Spleen V(D)J recombination
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