Effect of Lercanidipine on the Pharmacokinetics‐Pharmacodynamics of Carvedilol Enantiomers in Patients With Chronic Kidney Disease

This study evaluates the carvedilol‐lercanidipine drug interaction, and the influence of chronic kidney disease (CKD) on both drugs. Patients with high blood pressure (8 with normal renal function [control] and 8 with CKD with estimated glomerular filtration rate categories of G3b to G5 [12‐38 mL/mi...

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Veröffentlicht in:	Journal of clinical pharmacology 2020-01, Vol.60 (1), p.75-85
Hauptverfasser:	Hanauer Schaab, Estela, Lanchote, Vera Lucia, Balthazar Nardotto, Glauco Henrique, Marques Pereira, Maria Paula, Dantas, Márcio, Paiva, Carlos Eduardo, Barbosa Coelho, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Antihypertensive Agents - administration & dosage Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacokinetics Antihypertensive Agents - therapeutic use Blood pressure carvedilol Carvedilol - administration & dosage Carvedilol - chemistry Carvedilol - pharmacokinetics Carvedilol - therapeutic use Case-Control Studies chronic kidney disease Cross-Over Studies Cytochrome P-450 Enzyme System - metabolism Dihydropyridines - administration & dosage Dihydropyridines - pharmacokinetics Dihydropyridines - therapeutic use Drug interaction Drug Interactions drug‐drug interaction Enantiomers Exposure Female Glomerular Filtration Rate Heart rate Heart Rate - drug effects Humans Hypertension Hypertension - complications Hypertension - drug therapy Isometric Kidney diseases Kidneys lercanidipine Male Middle Aged Pharmacodynamics Pharmacokinetics Renal function Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - metabolism Stereoisomerism Titration
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