Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study
Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac...
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Veröffentlicht in: | The American heart journal 2020-01, Vol.219, p.89-98 |
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creator | Leerink, Jan M. Feijen, E. Lieke A.M. van der Pal, Helena J.H. Kok, Wouter E.M. Mavinkurve-Groothuis, Annelies M.C. Kapusta, Livia Pinto, Yigal M. Maas, Angela H.E.M. Bellersen, Louise Teske, Arco J. Ronckers, Cécile M. Louwerens, Marloes van Dalen, Elvira C. van Dulmen-den Broeder, Eline Batenburg, Lilian van der Heiden-van der Loo, Margriet van den Heuvel-Eibrink, Marry M. van Leeuwen, Flora E. de Vries, Andrica C.H. Weijers, Gert de Korte, Chris L. Loonen, Jacqueline J. Neggers, Sebastian J.C.M.M. Versluys, A.B. Birgitta Tissing, Wim J.E. Kremer, Leontien C.M. |
description | Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure.
To describe the methodology of the Dutch LATER cardiology study (LATER CARD).
The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings.
The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure. |
doi_str_mv | 10.1016/j.ahj.2019.10.010 |
format | Article |
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To describe the methodology of the Dutch LATER cardiology study (LATER CARD).
The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings.
The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2019.10.010</identifier><identifier>PMID: 31733449</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Apoptosis ; Biomarkers ; Biomarkers - blood ; Cancer ; Cancer Survivors ; Cancer therapies ; Cardiology ; Cardiomyocytes ; Child ; Child, Preschool ; Childhood ; Children ; Congestive heart failure ; Cross-Sectional Studies ; Diagnostic software ; Diagnostic systems ; Early Diagnosis ; Echocardiography ; EKG ; Electrocardiography ; Female ; Health risk assessment ; Heart Diseases - blood ; Heart Diseases - diagnosis ; Heart Failure ; Humans ; Infant ; Infant, Newborn ; Inflammation ; Male ; Medical diagnosis ; Mortality ; Myocytes, Cardiac - physiology ; Neoplasms - therapy ; Netherlands ; Oxidative Stress ; Risk analysis ; Risk Factors ; Surveillance ; Therapy ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - diagnosis ; Ventricular Remodeling</subject><ispartof>The American heart journal, 2020-01, Vol.219, p.89-98</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.</rights><rights>2019. The Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-be0d764bd5e7069691b078323d1a70d6ed4cbba9d8dd9c4f941b13d2a5f8efc43</citedby><cites>FETCH-LOGICAL-c424t-be0d764bd5e7069691b078323d1a70d6ed4cbba9d8dd9c4f941b13d2a5f8efc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002870319302923$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31733449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leerink, Jan M.</creatorcontrib><creatorcontrib>Feijen, E. Lieke A.M.</creatorcontrib><creatorcontrib>van der Pal, Helena J.H.</creatorcontrib><creatorcontrib>Kok, Wouter E.M.</creatorcontrib><creatorcontrib>Mavinkurve-Groothuis, Annelies M.C.</creatorcontrib><creatorcontrib>Kapusta, Livia</creatorcontrib><creatorcontrib>Pinto, Yigal M.</creatorcontrib><creatorcontrib>Maas, Angela H.E.M.</creatorcontrib><creatorcontrib>Bellersen, Louise</creatorcontrib><creatorcontrib>Teske, Arco J.</creatorcontrib><creatorcontrib>Ronckers, Cécile M.</creatorcontrib><creatorcontrib>Louwerens, Marloes</creatorcontrib><creatorcontrib>van Dalen, Elvira C.</creatorcontrib><creatorcontrib>van Dulmen-den Broeder, Eline</creatorcontrib><creatorcontrib>Batenburg, Lilian</creatorcontrib><creatorcontrib>van der Heiden-van der Loo, Margriet</creatorcontrib><creatorcontrib>van den Heuvel-Eibrink, Marry M.</creatorcontrib><creatorcontrib>van Leeuwen, Flora E.</creatorcontrib><creatorcontrib>de Vries, Andrica C.H.</creatorcontrib><creatorcontrib>Weijers, Gert</creatorcontrib><creatorcontrib>de Korte, Chris L.</creatorcontrib><creatorcontrib>Loonen, Jacqueline J.</creatorcontrib><creatorcontrib>Neggers, Sebastian J.C.M.M.</creatorcontrib><creatorcontrib>Versluys, A.B. Birgitta</creatorcontrib><creatorcontrib>Tissing, Wim J.E.</creatorcontrib><creatorcontrib>Kremer, Leontien C.M.</creatorcontrib><creatorcontrib>on behalf of the LATER Study Group</creatorcontrib><creatorcontrib>LATER Study Group</creatorcontrib><title>Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure.
To describe the methodology of the Dutch LATER cardiology study (LATER CARD).
The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings.
The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.</description><subject>Adolescent</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cancer</subject><subject>Cancer Survivors</subject><subject>Cancer therapies</subject><subject>Cardiology</subject><subject>Cardiomyocytes</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Congestive heart failure</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>Early Diagnosis</subject><subject>Echocardiography</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - diagnosis</subject><subject>Heart Failure</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Mortality</subject><subject>Myocytes, Cardiac - physiology</subject><subject>Neoplasms - therapy</subject><subject>Netherlands</subject><subject>Oxidative Stress</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surveillance</subject><subject>Therapy</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - diagnosis</subject><subject>Ventricular Remodeling</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc9u1DAQxi0EokvhAbggS1zgkMVO3CSmp6p_AGkREipny_GMG6_SeLGdlfJsvBxOU7ggcRrN-JvfeOYj5DVnW854_WG_1f1-WzIuc75lnD0hG85kU9SNEE_JhjFWFm3DqhPyIsZ9TuuyrZ-Tk4o3VSWE3JBfV07fjT4mZ2jyfojU-kBRh2GmgAlNcn6k3lKjAzhtKMzRTuNadiM1vRug9x6yYDQYaJzC0R19iB_pV0y9Bz_4O2f0QHU8ZFxcYKlHejUl09NBJ6Ro7cOLtikT_kG-213cXn9_v35hwc00pgnml-SZ1UPEV4_xlPy4ub69_Fzsvn36cnmxK4woRSo6ZNDUooMzbFgta8k71rRVWQHXDYMaQZiu0xJaAGmElYJ3vIJSn9kWrRHVKXm7cg_B_5wwJrX3UxjzSFVWZdNKXkuZVXxVmeBjDGjVIbh7HWbFmVrsUnuV7VKLXUsp25V73jySp-4e4W_HH3-y4HwVYN7v6DCoaBzmq4AL-WQKvPsP_jeNNqnQ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Leerink, Jan M.</creator><creator>Feijen, E. 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Lieke A.M. ; van der Pal, Helena J.H. ; Kok, Wouter E.M. ; Mavinkurve-Groothuis, Annelies M.C. ; Kapusta, Livia ; Pinto, Yigal M. ; Maas, Angela H.E.M. ; Bellersen, Louise ; Teske, Arco J. ; Ronckers, Cécile M. ; Louwerens, Marloes ; van Dalen, Elvira C. ; van Dulmen-den Broeder, Eline ; Batenburg, Lilian ; van der Heiden-van der Loo, Margriet ; van den Heuvel-Eibrink, Marry M. ; van Leeuwen, Flora E. ; de Vries, Andrica C.H. ; Weijers, Gert ; de Korte, Chris L. ; Loonen, Jacqueline J. ; Neggers, Sebastian J.C.M.M. ; Versluys, A.B. 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Lieke A.M.</au><au>van der Pal, Helena J.H.</au><au>Kok, Wouter E.M.</au><au>Mavinkurve-Groothuis, Annelies M.C.</au><au>Kapusta, Livia</au><au>Pinto, Yigal M.</au><au>Maas, Angela H.E.M.</au><au>Bellersen, Louise</au><au>Teske, Arco J.</au><au>Ronckers, Cécile M.</au><au>Louwerens, Marloes</au><au>van Dalen, Elvira C.</au><au>van Dulmen-den Broeder, Eline</au><au>Batenburg, Lilian</au><au>van der Heiden-van der Loo, Margriet</au><au>van den Heuvel-Eibrink, Marry M.</au><au>van Leeuwen, Flora E.</au><au>de Vries, Andrica C.H.</au><au>Weijers, Gert</au><au>de Korte, Chris L.</au><au>Loonen, Jacqueline J.</au><au>Neggers, Sebastian J.C.M.M.</au><au>Versluys, A.B. Birgitta</au><au>Tissing, Wim J.E.</au><au>Kremer, Leontien C.M.</au><aucorp>on behalf of the LATER Study Group</aucorp><aucorp>LATER Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2020-01</date><risdate>2020</risdate><volume>219</volume><spage>89</spage><epage>98</epage><pages>89-98</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><abstract>Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure.
To describe the methodology of the Dutch LATER cardiology study (LATER CARD).
The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings.
The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31733449</pmid><doi>10.1016/j.ahj.2019.10.010</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0002-8703 |
ispartof | The American heart journal, 2020-01, Vol.219, p.89-98 |
issn | 0002-8703 1097-6744 |
language | eng |
recordid | cdi_proquest_journals_2327891699 |
source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Adolescent Apoptosis Biomarkers Biomarkers - blood Cancer Cancer Survivors Cancer therapies Cardiology Cardiomyocytes Child Child, Preschool Childhood Children Congestive heart failure Cross-Sectional Studies Diagnostic software Diagnostic systems Early Diagnosis Echocardiography EKG Electrocardiography Female Health risk assessment Heart Diseases - blood Heart Diseases - diagnosis Heart Failure Humans Infant Infant, Newborn Inflammation Male Medical diagnosis Mortality Myocytes, Cardiac - physiology Neoplasms - therapy Netherlands Oxidative Stress Risk analysis Risk Factors Surveillance Therapy Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - diagnosis Ventricular Remodeling |
title | Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T12%3A33%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostic%20tools%20for%20early%20detection%20of%20cardiac%20dysfunction%20in%20childhood%20cancer%20survivors:%20Methodological%20aspects%20of%20the%20Dutch%20late%20effects%20after%20childhood%20cancer%20(LATER)%20cardiology%20study&rft.jtitle=The%20American%20heart%20journal&rft.au=Leerink,%20Jan%20M.&rft.aucorp=on%20behalf%20of%20the%20LATER%20Study%20Group&rft.date=2020-01&rft.volume=219&rft.spage=89&rft.epage=98&rft.pages=89-98&rft.issn=0002-8703&rft.eissn=1097-6744&rft_id=info:doi/10.1016/j.ahj.2019.10.010&rft_dat=%3Cproquest_cross%3E2327891699%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2327891699&rft_id=info:pmid/31733449&rft_els_id=S0002870319302923&rfr_iscdi=true |