Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study

Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac...

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Veröffentlicht in:The American heart journal 2020-01, Vol.219, p.89-98
Hauptverfasser: Leerink, Jan M., Feijen, E. Lieke A.M., van der Pal, Helena J.H., Kok, Wouter E.M., Mavinkurve-Groothuis, Annelies M.C., Kapusta, Livia, Pinto, Yigal M., Maas, Angela H.E.M., Bellersen, Louise, Teske, Arco J., Ronckers, Cécile M., Louwerens, Marloes, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, Batenburg, Lilian, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., van Leeuwen, Flora E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline J., Neggers, Sebastian J.C.M.M., Versluys, A.B. Birgitta, Tissing, Wim J.E., Kremer, Leontien C.M.
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container_end_page 98
container_issue
container_start_page 89
container_title The American heart journal
container_volume 219
creator Leerink, Jan M.
Feijen, E. Lieke A.M.
van der Pal, Helena J.H.
Kok, Wouter E.M.
Mavinkurve-Groothuis, Annelies M.C.
Kapusta, Livia
Pinto, Yigal M.
Maas, Angela H.E.M.
Bellersen, Louise
Teske, Arco J.
Ronckers, Cécile M.
Louwerens, Marloes
van Dalen, Elvira C.
van Dulmen-den Broeder, Eline
Batenburg, Lilian
van der Heiden-van der Loo, Margriet
van den Heuvel-Eibrink, Marry M.
van Leeuwen, Flora E.
de Vries, Andrica C.H.
Weijers, Gert
de Korte, Chris L.
Loonen, Jacqueline J.
Neggers, Sebastian J.C.M.M.
Versluys, A.B. Birgitta
Tissing, Wim J.E.
Kremer, Leontien C.M.
description Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure. To describe the methodology of the Dutch LATER cardiology study (LATER CARD). The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings. The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.
doi_str_mv 10.1016/j.ahj.2019.10.010
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Lieke A.M. ; van der Pal, Helena J.H. ; Kok, Wouter E.M. ; Mavinkurve-Groothuis, Annelies M.C. ; Kapusta, Livia ; Pinto, Yigal M. ; Maas, Angela H.E.M. ; Bellersen, Louise ; Teske, Arco J. ; Ronckers, Cécile M. ; Louwerens, Marloes ; van Dalen, Elvira C. ; van Dulmen-den Broeder, Eline ; Batenburg, Lilian ; van der Heiden-van der Loo, Margriet ; van den Heuvel-Eibrink, Marry M. ; van Leeuwen, Flora E. ; de Vries, Andrica C.H. ; Weijers, Gert ; de Korte, Chris L. ; Loonen, Jacqueline J. ; Neggers, Sebastian J.C.M.M. ; Versluys, A.B. Birgitta ; Tissing, Wim J.E. ; Kremer, Leontien C.M. ; on behalf of the LATER Study Group ; LATER Study Group</creatorcontrib><description>Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure. To describe the methodology of the Dutch LATER cardiology study (LATER CARD). The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings. The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2019.10.010</identifier><identifier>PMID: 31733449</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Apoptosis ; Biomarkers ; Biomarkers - blood ; Cancer ; Cancer Survivors ; Cancer therapies ; Cardiology ; Cardiomyocytes ; Child ; Child, Preschool ; Childhood ; Children ; Congestive heart failure ; Cross-Sectional Studies ; Diagnostic software ; Diagnostic systems ; Early Diagnosis ; Echocardiography ; EKG ; Electrocardiography ; Female ; Health risk assessment ; Heart Diseases - blood ; Heart Diseases - diagnosis ; Heart Failure ; Humans ; Infant ; Infant, Newborn ; Inflammation ; Male ; Medical diagnosis ; Mortality ; Myocytes, Cardiac - physiology ; Neoplasms - therapy ; Netherlands ; Oxidative Stress ; Risk analysis ; Risk Factors ; Surveillance ; Therapy ; Ventricular Dysfunction, Left - blood ; Ventricular Dysfunction, Left - diagnosis ; Ventricular Remodeling</subject><ispartof>The American heart journal, 2020-01, Vol.219, p.89-98</ispartof><rights>2019 The Authors</rights><rights>Copyright © 2019 The Authors. 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Lieke A.M.</creatorcontrib><creatorcontrib>van der Pal, Helena J.H.</creatorcontrib><creatorcontrib>Kok, Wouter E.M.</creatorcontrib><creatorcontrib>Mavinkurve-Groothuis, Annelies M.C.</creatorcontrib><creatorcontrib>Kapusta, Livia</creatorcontrib><creatorcontrib>Pinto, Yigal M.</creatorcontrib><creatorcontrib>Maas, Angela H.E.M.</creatorcontrib><creatorcontrib>Bellersen, Louise</creatorcontrib><creatorcontrib>Teske, Arco J.</creatorcontrib><creatorcontrib>Ronckers, Cécile M.</creatorcontrib><creatorcontrib>Louwerens, Marloes</creatorcontrib><creatorcontrib>van Dalen, Elvira C.</creatorcontrib><creatorcontrib>van Dulmen-den Broeder, Eline</creatorcontrib><creatorcontrib>Batenburg, Lilian</creatorcontrib><creatorcontrib>van der Heiden-van der Loo, Margriet</creatorcontrib><creatorcontrib>van den Heuvel-Eibrink, Marry M.</creatorcontrib><creatorcontrib>van Leeuwen, Flora E.</creatorcontrib><creatorcontrib>de Vries, Andrica C.H.</creatorcontrib><creatorcontrib>Weijers, Gert</creatorcontrib><creatorcontrib>de Korte, Chris L.</creatorcontrib><creatorcontrib>Loonen, Jacqueline J.</creatorcontrib><creatorcontrib>Neggers, Sebastian J.C.M.M.</creatorcontrib><creatorcontrib>Versluys, A.B. Birgitta</creatorcontrib><creatorcontrib>Tissing, Wim J.E.</creatorcontrib><creatorcontrib>Kremer, Leontien C.M.</creatorcontrib><creatorcontrib>on behalf of the LATER Study Group</creatorcontrib><creatorcontrib>LATER Study Group</creatorcontrib><title>Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure. To describe the methodology of the Dutch LATER cardiology study (LATER CARD). The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings. The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.</description><subject>Adolescent</subject><subject>Apoptosis</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Cancer</subject><subject>Cancer Survivors</subject><subject>Cancer therapies</subject><subject>Cardiology</subject><subject>Cardiomyocytes</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Congestive heart failure</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>Early Diagnosis</subject><subject>Echocardiography</subject><subject>EKG</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Heart Diseases - blood</subject><subject>Heart Diseases - diagnosis</subject><subject>Heart Failure</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Mortality</subject><subject>Myocytes, Cardiac - physiology</subject><subject>Neoplasms - therapy</subject><subject>Netherlands</subject><subject>Oxidative Stress</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Surveillance</subject><subject>Therapy</subject><subject>Ventricular Dysfunction, Left - blood</subject><subject>Ventricular Dysfunction, Left - diagnosis</subject><subject>Ventricular Remodeling</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc9u1DAQxi0EokvhAbggS1zgkMVO3CSmp6p_AGkREipny_GMG6_SeLGdlfJsvBxOU7ggcRrN-JvfeOYj5DVnW854_WG_1f1-WzIuc75lnD0hG85kU9SNEE_JhjFWFm3DqhPyIsZ9TuuyrZ-Tk4o3VSWE3JBfV07fjT4mZ2jyfojU-kBRh2GmgAlNcn6k3lKjAzhtKMzRTuNadiM1vRug9x6yYDQYaJzC0R19iB_pV0y9Bz_4O2f0QHU8ZFxcYKlHejUl09NBJ6Ro7cOLtikT_kG-213cXn9_v35hwc00pgnml-SZ1UPEV4_xlPy4ub69_Fzsvn36cnmxK4woRSo6ZNDUooMzbFgta8k71rRVWQHXDYMaQZiu0xJaAGmElYJ3vIJSn9kWrRHVKXm7cg_B_5wwJrX3UxjzSFVWZdNKXkuZVXxVmeBjDGjVIbh7HWbFmVrsUnuV7VKLXUsp25V73jySp-4e4W_HH3-y4HwVYN7v6DCoaBzmq4AL-WQKvPsP_jeNNqnQ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Leerink, Jan M.</creator><creator>Feijen, E. 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Birgitta</creatorcontrib><creatorcontrib>Tissing, Wim J.E.</creatorcontrib><creatorcontrib>Kremer, Leontien C.M.</creatorcontrib><creatorcontrib>on behalf of the LATER Study Group</creatorcontrib><creatorcontrib>LATER Study Group</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing &amp; Allied Health Source</collection><collection>Physical Education Index</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leerink, Jan M.</au><au>Feijen, E. Lieke A.M.</au><au>van der Pal, Helena J.H.</au><au>Kok, Wouter E.M.</au><au>Mavinkurve-Groothuis, Annelies M.C.</au><au>Kapusta, Livia</au><au>Pinto, Yigal M.</au><au>Maas, Angela H.E.M.</au><au>Bellersen, Louise</au><au>Teske, Arco J.</au><au>Ronckers, Cécile M.</au><au>Louwerens, Marloes</au><au>van Dalen, Elvira C.</au><au>van Dulmen-den Broeder, Eline</au><au>Batenburg, Lilian</au><au>van der Heiden-van der Loo, Margriet</au><au>van den Heuvel-Eibrink, Marry M.</au><au>van Leeuwen, Flora E.</au><au>de Vries, Andrica C.H.</au><au>Weijers, Gert</au><au>de Korte, Chris L.</au><au>Loonen, Jacqueline J.</au><au>Neggers, Sebastian J.C.M.M.</au><au>Versluys, A.B. Birgitta</au><au>Tissing, Wim J.E.</au><au>Kremer, Leontien C.M.</au><aucorp>on behalf of the LATER Study Group</aucorp><aucorp>LATER Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2020-01</date><risdate>2020</risdate><volume>219</volume><spage>89</spage><epage>98</epage><pages>89-98</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><abstract>Cancer therapy-related cardiac dysfunction and heart failure are major problems in long-term childhood cancer survivors (CCS). We hypothesize that assessment of more sensitive echo- and electrocardiographic measurements, and/or biomarkers will allow for improved recognition of patients with cardiac dysfunction before heart failure develops, and may also identify patients at lower risk for heart failure. To describe the methodology of the Dutch LATER cardiology study (LATER CARD). The LATER CARD study is a cross-sectional study in long-term CCS treated with (potentially) cardiotoxic cancer therapies and sibling controls. We will evaluate 1) the prevalence and associated (treatment related) risk factors of subclinical cardiac dysfunction in CCS compared to sibling controls and 2) the diagnostic value of echocardiography including myocardial strain and diastolic function parameters, blood biomarkers for cardiomyocyte apoptosis, oxidative stress, cardiac remodeling and inflammation and ECG or combinations of them in the surveillance for cancer therapy-related cardiac dysfunction. From 2017 to 2020 we expect to include 1900 CCS and 500 siblings. The LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31733449</pmid><doi>10.1016/j.ahj.2019.10.010</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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identifier ISSN: 0002-8703
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issn 0002-8703
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language eng
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Adolescent
Apoptosis
Biomarkers
Biomarkers - blood
Cancer
Cancer Survivors
Cancer therapies
Cardiology
Cardiomyocytes
Child
Child, Preschool
Childhood
Children
Congestive heart failure
Cross-Sectional Studies
Diagnostic software
Diagnostic systems
Early Diagnosis
Echocardiography
EKG
Electrocardiography
Female
Health risk assessment
Heart Diseases - blood
Heart Diseases - diagnosis
Heart Failure
Humans
Infant
Infant, Newborn
Inflammation
Male
Medical diagnosis
Mortality
Myocytes, Cardiac - physiology
Neoplasms - therapy
Netherlands
Oxidative Stress
Risk analysis
Risk Factors
Surveillance
Therapy
Ventricular Dysfunction, Left - blood
Ventricular Dysfunction, Left - diagnosis
Ventricular Remodeling
title Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch late effects after childhood cancer (LATER) cardiology study
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