Prospective study of a systemic sclerosis/dermatomyositis overlap patient presenting with anti-Ku and anti-Ki antibodies

Prospective study of a systemic sclerosis/dermatomyositis overlap patient presenting with anti-Ku and anti-Ki antibodies

A 60-year-old woman visited the Keigu Clinic in January 1998 complaining of morning stiffness and flexion contracture of the distal interphalangeal joint. Blood tests showed the presence of antinuclear antibody at a 1 : 40 dilution with speckled staining. She was suspected of having Heberden's...

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Veröffentlicht in:Modern rheumatology 2002-09, Vol.12 (3), p.0253
Hauptverfasser: Miyachi, K, Hankins, R W, Mimori, T, Okano, Y, Akizuki, M
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Case studies
Disease
Immune system
Joints
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creator Miyachi, K
Hankins, R W
Mimori, T
Okano, Y
Akizuki, M
description A 60-year-old woman visited the Keigu Clinic in January 1998 complaining of morning stiffness and flexion contracture of the distal interphalangeal joint. Blood tests showed the presence of antinuclear antibody at a 1 : 40 dilution with speckled staining. She was suspected of having Heberden's node. Nine months later, she developed Raynaud's phenomenon, sclerodactyly, and Gottron's sign, and was diagnosed with systemic sclerosis/dermatomyositis (SSc/DM) overlap. Blood tests revealed the presence of antinuclear antibody at a 1 : 5120 dilution, along with high titer of anti-Ku and anti-Ki antibodies. Subsequently, the patient developed interstitial pneumonia in January 2000. It is thought that the appearance of antinuclear antibody and development of other immunological events played an important role in determining this patient's limited SSc/DM overlap.[PUBLICATION ABSTRACT]
doi_str_mv 10.1007/s101650200045
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source SpringerNature Journals; Oxford University Press Journals All Titles (1996-Current)
subjects Case studies
Disease
Immune system
Joints
title Prospective study of a systemic sclerosis/dermatomyositis overlap patient presenting with anti-Ku and anti-Ki antibodies
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