New Lignans from roots of Kadsura coccinea
Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1–4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6–12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13...
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| Veröffentlicht in: | Fitoterapia 2019-11, Vol.139, p.104368, Article 104368 |
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| container_title | Fitoterapia |
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| creator | Yang, Yupei Liu, Yongbei Daniyal, Muhammad Yu, Huanghe Xie, Qingling Li, Bin Jian, Yuqing Man, Rongyong Wang, Sanhu Zhou, Xiaoling Liu, Bin Wang, Wei |
| description | Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1–4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6–12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8–12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxicity activities, compounds 3, 6 and 7 showed weak cytotoxicity against four human cancer cell lines (HepG-2, HCT-116, BGC-823 and Hela) with IC50 values range from 13.04 to 21.93 μM. Compounds 1 and 7 demonstrated potential anti-RA (rheumatoid arthritis) activity against RA-FLS cell line with IC50 values of 14.57 and 11.70 μM, respectively.
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| doi_str_mv | 10.1016/j.fitote.2019.104368 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0367-326X</identifier><identifier>EISSN: 1873-6971</identifier><identifier>DOI: 10.1016/j.fitote.2019.104368</identifier><identifier>PMID: 31629046</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Antineoplastic Agents, Phytogenic - isolation & purification ; Antineoplastic Agents, Phytogenic - pharmacology ; Antirheumatic Agents - isolation & purification ; Antirheumatic Agents - pharmacology ; Arthritis ; Biotechnology ; Cell Line, Tumor ; China ; Cyclooctanes ; Cytotoxicity ; Heilaohu ; Humans ; Kadsura - chemistry ; Kadsura coccinea ; Lignan ; Lignans ; Lignans - isolation & purification ; Lignans - pharmacology ; Molecular Structure ; NMR ; Nuclear magnetic resonance ; Phytochemicals - isolation & purification ; Phytochemicals - pharmacology ; Plant Roots - chemistry ; Rheumatoid arthritis ; Roots ; Toxicity ; Tujia ethnomedicine ; Tumor cell lines</subject><ispartof>Fitoterapia, 2019-11, Vol.139, p.104368, Article 104368</ispartof><rights>2019</rights><rights>Copyright © 2019. Published by Elsevier B.V.</rights><rights>Copyright Elsevier Science Ltd. Nov 2019</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-b146cc04075d4320f16f69fd8d8f1b9a96a6f3188c5596675a88035d4630cbd63</citedby><cites>FETCH-LOGICAL-c390t-b146cc04075d4320f16f69fd8d8f1b9a96a6f3188c5596675a88035d4630cbd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0367326X19317800$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31629046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Yupei</creatorcontrib><creatorcontrib>Liu, Yongbei</creatorcontrib><creatorcontrib>Daniyal, Muhammad</creatorcontrib><creatorcontrib>Yu, Huanghe</creatorcontrib><creatorcontrib>Xie, Qingling</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Jian, Yuqing</creatorcontrib><creatorcontrib>Man, Rongyong</creatorcontrib><creatorcontrib>Wang, Sanhu</creatorcontrib><creatorcontrib>Zhou, Xiaoling</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><title>New Lignans from roots of Kadsura coccinea</title><title>Fitoterapia</title><addtitle>Fitoterapia</addtitle><description>Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1–4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6–12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8–12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxicity activities, compounds 3, 6 and 7 showed weak cytotoxicity against four human cancer cell lines (HepG-2, HCT-116, BGC-823 and Hela) with IC50 values range from 13.04 to 21.93 μM. Compounds 1 and 7 demonstrated potential anti-RA (rheumatoid arthritis) activity against RA-FLS cell line with IC50 values of 14.57 and 11.70 μM, respectively.
[Display omitted]</description><subject>Antineoplastic Agents, Phytogenic - isolation & purification</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antirheumatic Agents - isolation & purification</subject><subject>Antirheumatic Agents - pharmacology</subject><subject>Arthritis</subject><subject>Biotechnology</subject><subject>Cell Line, Tumor</subject><subject>China</subject><subject>Cyclooctanes</subject><subject>Cytotoxicity</subject><subject>Heilaohu</subject><subject>Humans</subject><subject>Kadsura - chemistry</subject><subject>Kadsura coccinea</subject><subject>Lignan</subject><subject>Lignans</subject><subject>Lignans - isolation & purification</subject><subject>Lignans - pharmacology</subject><subject>Molecular Structure</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Phytochemicals - isolation & purification</subject><subject>Phytochemicals - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Rheumatoid arthritis</subject><subject>Roots</subject><subject>Toxicity</subject><subject>Tujia ethnomedicine</subject><subject>Tumor cell lines</subject><issn>0367-326X</issn><issn>1873-6971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rr6D0QK3oSuSZNOk4sgi1-46EXBW0jzISlusybtiv_eLl09ehoYnvcd5kHolOA5wQQum7nzXejsvMBEDCtGge-hKeEVzUFUZB9NMYUqpwW8TdBRSg3GpKSMHKIJJVAIzGCKLp7sV7b0761qU-ZiWGUxhC5lwWWPyqQ-qkwHrX1r1TE6cOoj2ZPdnKHX25uXxX2-fL57WFwvc00F7vKaMNAaM1yVhtECOwIOhDPccEdqoQQocJRwrstSAFSl4hzTgQWKdW2AztD52LuO4bO3qZNN6GM7nJQFLSpKGCvpQLGR0jGkFK2T6-hXKn5LguVWkGzkKEhuBclR0BA725X39cqav9CvkQG4GgE7vLjxNsqkvW21NT5a3UkT_P8XfgBZIXXh</recordid><startdate>201911</startdate><enddate>201911</enddate><creator>Yang, Yupei</creator><creator>Liu, Yongbei</creator><creator>Daniyal, Muhammad</creator><creator>Yu, Huanghe</creator><creator>Xie, Qingling</creator><creator>Li, Bin</creator><creator>Jian, Yuqing</creator><creator>Man, Rongyong</creator><creator>Wang, Sanhu</creator><creator>Zhou, Xiaoling</creator><creator>Liu, Bin</creator><creator>Wang, Wei</creator><general>Elsevier B.V</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>201911</creationdate><title>New Lignans from roots of Kadsura coccinea</title><author>Yang, Yupei ; Liu, Yongbei ; Daniyal, Muhammad ; Yu, Huanghe ; Xie, Qingling ; Li, Bin ; Jian, Yuqing ; Man, Rongyong ; Wang, Sanhu ; Zhou, Xiaoling ; Liu, Bin ; Wang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-b146cc04075d4320f16f69fd8d8f1b9a96a6f3188c5596675a88035d4630cbd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antineoplastic Agents, Phytogenic - isolation & purification</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antirheumatic Agents - isolation & purification</topic><topic>Antirheumatic Agents - pharmacology</topic><topic>Arthritis</topic><topic>Biotechnology</topic><topic>Cell Line, Tumor</topic><topic>China</topic><topic>Cyclooctanes</topic><topic>Cytotoxicity</topic><topic>Heilaohu</topic><topic>Humans</topic><topic>Kadsura - chemistry</topic><topic>Kadsura coccinea</topic><topic>Lignan</topic><topic>Lignans</topic><topic>Lignans - isolation & purification</topic><topic>Lignans - pharmacology</topic><topic>Molecular Structure</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Phytochemicals - isolation & purification</topic><topic>Phytochemicals - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Rheumatoid arthritis</topic><topic>Roots</topic><topic>Toxicity</topic><topic>Tujia ethnomedicine</topic><topic>Tumor cell lines</topic><toplevel>online_resources</toplevel><creatorcontrib>Yang, Yupei</creatorcontrib><creatorcontrib>Liu, Yongbei</creatorcontrib><creatorcontrib>Daniyal, Muhammad</creatorcontrib><creatorcontrib>Yu, Huanghe</creatorcontrib><creatorcontrib>Xie, Qingling</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><creatorcontrib>Jian, Yuqing</creatorcontrib><creatorcontrib>Man, Rongyong</creatorcontrib><creatorcontrib>Wang, Sanhu</creatorcontrib><creatorcontrib>Zhou, Xiaoling</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Fitoterapia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Yupei</au><au>Liu, Yongbei</au><au>Daniyal, Muhammad</au><au>Yu, Huanghe</au><au>Xie, Qingling</au><au>Li, Bin</au><au>Jian, Yuqing</au><au>Man, Rongyong</au><au>Wang, Sanhu</au><au>Zhou, Xiaoling</au><au>Liu, Bin</au><au>Wang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New Lignans from roots of Kadsura coccinea</atitle><jtitle>Fitoterapia</jtitle><addtitle>Fitoterapia</addtitle><date>2019-11</date><risdate>2019</risdate><volume>139</volume><spage>104368</spage><pages>104368-</pages><artnum>104368</artnum><issn>0367-326X</issn><eissn>1873-6971</eissn><abstract>Four new dibenzocyclooctadiene lignans, named heilaohusus A-D (1–4), one new arylnaphthalene lignan named heilaohusu E (5), and seven known analogues (6–12) were isolated from the roots of Kadsura coccinea. Their structures and configurations were elucidated by a combination of HR-ESI-MS, 1H NMR, 13C NMR, HSQC, HMBC, NOESY and CD spectra. Among the known compounds, compounds 6 and 8–12 were isolated from this plant for the first time. All of compounds were evaluated for their cytotoxicity activities, compounds 3, 6 and 7 showed weak cytotoxicity against four human cancer cell lines (HepG-2, HCT-116, BGC-823 and Hela) with IC50 values range from 13.04 to 21.93 μM. Compounds 1 and 7 demonstrated potential anti-RA (rheumatoid arthritis) activity against RA-FLS cell line with IC50 values of 14.57 and 11.70 μM, respectively.
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| subjects | Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antirheumatic Agents - isolation & purification Antirheumatic Agents - pharmacology Arthritis Biotechnology Cell Line, Tumor China Cyclooctanes Cytotoxicity Heilaohu Humans Kadsura - chemistry Kadsura coccinea Lignan Lignans Lignans - isolation & purification Lignans - pharmacology Molecular Structure NMR Nuclear magnetic resonance Phytochemicals - isolation & purification Phytochemicals - pharmacology Plant Roots - chemistry Rheumatoid arthritis Roots Toxicity Tujia ethnomedicine Tumor cell lines |
| title | New Lignans from roots of Kadsura coccinea |
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