Air Pollution Exposure and Lung Function Until Age 16 Years: The PIAMA Birth Cohort Study
Purpose of the Study: Evidence for the effects of air pollution exposure on lung function growth into adolescence is scarce. Therefore, the purpose of this study was to investigate the associations of air pollution exposure from birth with lung function growth from ages 8 to 16 and lung function at...
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| Veröffentlicht in: | Pediatrics (Evanston) 2019-12, Vol.144 (Supplement_1), p.S11-S12 |
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| description | Purpose of the Study: Evidence for the effects of air pollution exposure on lung function growth into adolescence is scarce. Therefore, the purpose of this study was to investigate the associations of air pollution exposure from birth with lung function growth from ages 8 to 16 and lung function at age 16. Potential confounders (sex and asthma diagnosis) were also explored. Study Population: The study was performed within the Dutch population-based Prevention and Incidence of Asthma and Mite Allergy birth cohort. From the 3963 pregnant women initially enrolled, 915 children (mean age: 16.3 years) had sufficient longitudinal data for this study. Methods: Both longitudinal (n = 915) and cross-sectional (n = 721) analyses were conducted. Researchers estimated residential concentrations of nitrogen dioxide, "soot," and particulate matter (PMx, where x is the 50% cutoff aerodynamic diameter in μm) with diameters of |
| doi_str_mv | 10.1542/peds.2019-2461O |
| format | Article |
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Therefore, the purpose of this study was to investigate the associations of air pollution exposure from birth with lung function growth from ages 8 to 16 and lung function at age 16. Potential confounders (sex and asthma diagnosis) were also explored. Study Population: The study was performed within the Dutch population-based Prevention and Incidence of Asthma and Mite Allergy birth cohort. From the 3963 pregnant women initially enrolled, 915 children (mean age: 16.3 years) had sufficient longitudinal data for this study. Methods: Both longitudinal (n = 915) and cross-sectional (n = 721) analyses were conducted. Researchers estimated residential concentrations of nitrogen dioxide, "soot," and particulate matter (PMx, where x is the 50% cutoff aerodynamic diameter in μm) with diameters of <2.5 μm (PM2.5), <10 μm (PM10), and 2.5 to 10 μm (PMcoarse) during the preschool, primary school, and secondary school time windows by land use regression models. Associations with (growth in) forced expiratory volume in 1 second (FEV1) and forced vital capacity were analyzed by linear (mixed effects) regression. Results: Greater air pollution exposure was associated with reduced FEV1 growth (eg, adjusted difference: −0.26% [95% confidence interval: −0.49 to −0.03%] per interquartile range increase in secondary school PM2.5) and lower FEV1 (adjusted difference: −2.36% [95% confidence interval: −3.76 to −0.94%]) but was not adversely associated with forced vital capacity. Associations with FEV1 were stronger in boys than girls and were not modified by asthma status. Conclusions: Greater air pollution exposure may lead to increased airway obstruction but not reduced lung volume in adolescence.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2019-2461O</identifier><language>eng</language><publisher>Evanston: American Academy of Pediatrics</publisher><subject>Adolescents ; Age ; Air pollution ; Air pollution effects ; Airway management ; Allergies ; Asthma ; Child development ; Cohort analysis ; Confidence intervals ; Exposure ; Land use ; Lungs ; Nitrogen dioxide ; Particulate emissions ; Particulate matter ; Pediatrics ; Pollution ; Pollution effects ; Population studies ; Regression analysis ; Respiratory function</subject><ispartof>Pediatrics (Evanston), 2019-12, Vol.144 (Supplement_1), p.S11-S12</ispartof><rights>Copyright American Academy of Pediatrics Dec 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Kloepfer, Kirsten M.</creatorcontrib><title>Air Pollution Exposure and Lung Function Until Age 16 Years: The PIAMA Birth Cohort Study</title><title>Pediatrics (Evanston)</title><description>Purpose of the Study: Evidence for the effects of air pollution exposure on lung function growth into adolescence is scarce. Therefore, the purpose of this study was to investigate the associations of air pollution exposure from birth with lung function growth from ages 8 to 16 and lung function at age 16. Potential confounders (sex and asthma diagnosis) were also explored. Study Population: The study was performed within the Dutch population-based Prevention and Incidence of Asthma and Mite Allergy birth cohort. From the 3963 pregnant women initially enrolled, 915 children (mean age: 16.3 years) had sufficient longitudinal data for this study. Methods: Both longitudinal (n = 915) and cross-sectional (n = 721) analyses were conducted. Researchers estimated residential concentrations of nitrogen dioxide, "soot," and particulate matter (PMx, where x is the 50% cutoff aerodynamic diameter in μm) with diameters of <2.5 μm (PM2.5), <10 μm (PM10), and 2.5 to 10 μm (PMcoarse) during the preschool, primary school, and secondary school time windows by land use regression models. Associations with (growth in) forced expiratory volume in 1 second (FEV1) and forced vital capacity were analyzed by linear (mixed effects) regression. Results: Greater air pollution exposure was associated with reduced FEV1 growth (eg, adjusted difference: −0.26% [95% confidence interval: −0.49 to −0.03%] per interquartile range increase in secondary school PM2.5) and lower FEV1 (adjusted difference: −2.36% [95% confidence interval: −3.76 to −0.94%]) but was not adversely associated with forced vital capacity. Associations with FEV1 were stronger in boys than girls and were not modified by asthma status. Conclusions: Greater air pollution exposure may lead to increased airway obstruction but not reduced lung volume in adolescence.</description><subject>Adolescents</subject><subject>Age</subject><subject>Air pollution</subject><subject>Air pollution effects</subject><subject>Airway management</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Child development</subject><subject>Cohort analysis</subject><subject>Confidence intervals</subject><subject>Exposure</subject><subject>Land use</subject><subject>Lungs</subject><subject>Nitrogen dioxide</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Pediatrics</subject><subject>Pollution</subject><subject>Pollution effects</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Respiratory function</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNotkM9PwjAcxRujiYievTbxPPj2J9TbJKAkGEjEA6em2zoYmets10T-ewd6eof38t7LB6FHAiMiOB23tggjCkQllEuyvkIDAmqacDoR12gAwEjCAcQtugvhCABcTOgA7dLK442r69hVrsHzn9aF6C02TYFXsdnjRWzyi_XZdFWN073FROKdNT484-3B4s0yfU_xS-W7A565g_Md_uhicbpHN6Wpg3341yHaLubb2VuyWr8uZ-kqyft_LuHEZFSwMgOpcqGykgLjhgnKSZlLQ3uD8nxCLckArOQqV2CEsUB4JgrJhujpr7b17jva0Omji77pFzVlVE4lF1L1qfFfKvcuBG9L3frqy_iTJqDP-PQZnz7j0xd87BcmEWFq</recordid><startdate>20191201</startdate><enddate>20191201</enddate><creator>Kloepfer, Kirsten M.</creator><general>American Academy of Pediatrics</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope></search><sort><creationdate>20191201</creationdate><title>Air Pollution Exposure and Lung Function Until Age 16 Years: The PIAMA Birth Cohort Study</title><author>Kloepfer, Kirsten M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c109o-41ab253fb069c59bf2034a35241fc6a2fb024c72e1b00e649c90a5ae014b5d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescents</topic><topic>Age</topic><topic>Air pollution</topic><topic>Air pollution effects</topic><topic>Airway management</topic><topic>Allergies</topic><topic>Asthma</topic><topic>Child development</topic><topic>Cohort analysis</topic><topic>Confidence intervals</topic><topic>Exposure</topic><topic>Land use</topic><topic>Lungs</topic><topic>Nitrogen dioxide</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Pediatrics</topic><topic>Pollution</topic><topic>Pollution effects</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Respiratory function</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kloepfer, Kirsten M.</creatorcontrib><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kloepfer, Kirsten M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Air Pollution Exposure and Lung Function Until Age 16 Years: The PIAMA Birth Cohort Study</atitle><jtitle>Pediatrics (Evanston)</jtitle><date>2019-12-01</date><risdate>2019</risdate><volume>144</volume><issue>Supplement_1</issue><spage>S11</spage><epage>S12</epage><pages>S11-S12</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>Purpose of the Study: Evidence for the effects of air pollution exposure on lung function growth into adolescence is scarce. Therefore, the purpose of this study was to investigate the associations of air pollution exposure from birth with lung function growth from ages 8 to 16 and lung function at age 16. Potential confounders (sex and asthma diagnosis) were also explored. Study Population: The study was performed within the Dutch population-based Prevention and Incidence of Asthma and Mite Allergy birth cohort. From the 3963 pregnant women initially enrolled, 915 children (mean age: 16.3 years) had sufficient longitudinal data for this study. Methods: Both longitudinal (n = 915) and cross-sectional (n = 721) analyses were conducted. Researchers estimated residential concentrations of nitrogen dioxide, "soot," and particulate matter (PMx, where x is the 50% cutoff aerodynamic diameter in μm) with diameters of <2.5 μm (PM2.5), <10 μm (PM10), and 2.5 to 10 μm (PMcoarse) during the preschool, primary school, and secondary school time windows by land use regression models. Associations with (growth in) forced expiratory volume in 1 second (FEV1) and forced vital capacity were analyzed by linear (mixed effects) regression. Results: Greater air pollution exposure was associated with reduced FEV1 growth (eg, adjusted difference: −0.26% [95% confidence interval: −0.49 to −0.03%] per interquartile range increase in secondary school PM2.5) and lower FEV1 (adjusted difference: −2.36% [95% confidence interval: −3.76 to −0.94%]) but was not adversely associated with forced vital capacity. Associations with FEV1 were stronger in boys than girls and were not modified by asthma status. Conclusions: Greater air pollution exposure may lead to increased airway obstruction but not reduced lung volume in adolescence.</abstract><cop>Evanston</cop><pub>American Academy of Pediatrics</pub><doi>10.1542/peds.2019-2461O</doi><oa>free_for_read</oa></addata></record> |
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| source | Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adolescents Age Air pollution Air pollution effects Airway management Allergies Asthma Child development Cohort analysis Confidence intervals Exposure Land use Lungs Nitrogen dioxide Particulate emissions Particulate matter Pediatrics Pollution Pollution effects Population studies Regression analysis Respiratory function |
| title | Air Pollution Exposure and Lung Function Until Age 16 Years: The PIAMA Birth Cohort Study |
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