Requirement of Notch activation during regeneration of the intestinal epithelia

Notch signaling regulates cell differentiation and proliferation, contributing to the maintenance of diverse tissues including the intestinal epithelia. However, its role in tissue regeneration is less understood. Here, we show that Notch signaling is activated in a greater number of intestinal epit...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2009-01, Vol.296 (1), p.G23-G35
Hauptverfasser:	Okamoto, Ryuichi, Tsuchiya, Kiichiro, Nemoto, Yasuhiro, Akiyama, Junko, Nakamura, Tetsuya, Kanai, Takanori, Watanabe, Mamoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - pharmacology Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Animals Azepines - pharmacology Basic Helix-Loop-Helix Transcription Factors - metabolism Cell Differentiation Cell division Cell Proliferation Cells Colitis - chemically induced Colitis - metabolism Colitis - pathology Colon - drug effects Colon - metabolism Colon - pathology Dextran Sulfate Disease Models, Animal Enzyme Inhibitors - pharmacology Gastroenterology Goblet Cells - metabolism Goblet Cells - pathology Group II Phospholipases A2 - metabolism Homeodomain Proteins - metabolism HT29 Cells Humans Inflammatory bowel disease Mice Mice, Inbred C57BL Paneth Cells - metabolism Paneth Cells - pathology Receptor, Notch1 - metabolism Receptors, Notch - genetics Receptors, Notch - metabolism Regeneration - drug effects Signal Transduction - drug effects Tissues Transcription Factor HES-1
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