Reduced susceptibility of muscle-specific insulin receptor knockout mice to colon carcinogenesis

Insulin resistance is a risk factor for colon cancer, but it is not clear which of its metabolic sequelae are involved. The objective of this study was to determine whether increased adiposity and elevated circulating lipids commonly seen in insulin resistance promote colon carcinogenesis independen...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2008-03, Vol.294 (3), p.G679-G686
Hauptverfasser:	Ealey, Kafi N, Lu, Suying, Lau, Dominic, Archer, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - blood Adipose Tissue - anatomy & histology Adipose Tissue - metabolism Adipose Tissue - physiology Adiposity - genetics Adiposity - physiology Aging - physiology Animals Blood Glucose - metabolism Blotting, Western Body Weight - physiology Carcinogenicity Tests Colonic Neoplasms - chemically induced Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Fatty acids Fatty Acids, Nonesterified - blood Genotype & phenotype Glucose Tolerance Test Immunoprecipitation Insulin Insulin - blood Lipids Lipids - blood Male Metabolism Mice Mice, Knockout Receptor, Insulin - genetics Receptor, Insulin - physiology Risk factors Rodents Triglycerides - blood
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