Influence of pH on the phase distribution of nascent deoxycholic acid in fresh human cecal aspirates
Prolonged large bowel transit time and an associated increase in the proportion of deoxycholic acid (DCA) in serum and bile have been implicated in the development of cholesterol-rich gallstones and colon cancer. Prolongation of interstional transit also increases intracolonic pH that, we hpothesize...
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| Veröffentlicht in: | American journal of physiology: Gastrointestinal and liver physiology 2001-08, Vol.44 (2), p.G371-G374 |
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| container_end_page | G374 |
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| container_issue | 2 |
| container_start_page | G371 |
| container_title | American journal of physiology: Gastrointestinal and liver physiology |
| container_volume | 44 |
| creator | THOMAS, Linzi A VEYSEY, Martin J MURPHY, Gerard M DOWLING, R. Hermon |
| description | Prolonged large bowel transit time and an associated increase in the proportion of deoxycholic acid (DCA) in serum and bile have been implicated in the development of cholesterol-rich gallstones and colon cancer. Prolongation of interstional transit also increases intracolonic pH that, we hpothesized, should favor the solubilization and absorption of newly formed DCA within the colon. |
| format | Article |
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Exocrine pancreas ; Medical sciences ; Metabolism ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>American journal of physiology: Gastrointestinal and liver physiology, 2001-08, Vol.44 (2), p.G371-G374</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright American Physiological Society Aug 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1074945$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>THOMAS, Linzi A</creatorcontrib><creatorcontrib>VEYSEY, Martin J</creatorcontrib><creatorcontrib>MURPHY, Gerard M</creatorcontrib><creatorcontrib>DOWLING, R. Hermon</creatorcontrib><title>Influence of pH on the phase distribution of nascent deoxycholic acid in fresh human cecal aspirates</title><title>American journal of physiology: Gastrointestinal and liver physiology</title><description>Prolonged large bowel transit time and an associated increase in the proportion of deoxycholic acid (DCA) in serum and bile have been implicated in the development of cholesterol-rich gallstones and colon cancer. Prolongation of interstional transit also increases intracolonic pH that, we hpothesized, should favor the solubilization and absorption of newly formed DCA within the colon.</description><subject>Bile</subject><subject>Biological and medical sciences</subject><subject>Cholesterol</subject><subject>Colon</subject><subject>Colorectal cancer</subject><subject>Gallstones</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0193-1857</issn><issn>1522-1547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNotj09Lw0AUxBdRsFa_wyJeA9nsv-xRitpCwUvv4eXlLdmSbuJuAvbbG7CngZkfM8wd2whdVYXQyt6zTSmcLESt7SN7yvlclqWuhNiw7hD9sFBE4qPn056Pkc898amHTLwLeU6hXeaw2mseISPFmXc0_l6xH4eAHDB0PETuE-We98sFIkdCGDjkKSSYKT-zBw9Dppebbtnp8-O02xfH76_D7v1YTNrIwqBSSiuJgNLXWBtdgrNI4BVqbLG1ZeuNMrr2onZCgzVtSx1VncLaSZJb9vpfO6XxZ6E8N-dxSXFdbCpZaeuckSv0doPWLzD4BBFDbqYULpCujSitckrLP4Z3YAc</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>THOMAS, Linzi A</creator><creator>VEYSEY, Martin J</creator><creator>MURPHY, Gerard M</creator><creator>DOWLING, R. Hermon</creator><general>American Physiological Society</general><scope>IQODW</scope></search><sort><creationdate>20010801</creationdate><title>Influence of pH on the phase distribution of nascent deoxycholic acid in fresh human cecal aspirates</title><author>THOMAS, Linzi A ; VEYSEY, Martin J ; MURPHY, Gerard M ; DOWLING, R. Hermon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p563-6c444543cac3f8c8650a97ceaf4c5cbcb70bf64658f18915a76bbede2d4c893e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Bile</topic><topic>Biological and medical sciences</topic><topic>Cholesterol</topic><topic>Colon</topic><topic>Colorectal cancer</topic><topic>Gallstones</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMAS, Linzi A</creatorcontrib><creatorcontrib>VEYSEY, Martin J</creatorcontrib><creatorcontrib>MURPHY, Gerard M</creatorcontrib><creatorcontrib>DOWLING, R. Hermon</creatorcontrib><collection>Pascal-Francis</collection><jtitle>American journal of physiology: Gastrointestinal and liver physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THOMAS, Linzi A</au><au>VEYSEY, Martin J</au><au>MURPHY, Gerard M</au><au>DOWLING, R. Hermon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of pH on the phase distribution of nascent deoxycholic acid in fresh human cecal aspirates</atitle><jtitle>American journal of physiology: Gastrointestinal and liver physiology</jtitle><date>2001-08-01</date><risdate>2001</risdate><volume>44</volume><issue>2</issue><spage>G371</spage><epage>G374</epage><pages>G371-G374</pages><issn>0193-1857</issn><eissn>1522-1547</eissn><coden>APGPDF</coden><abstract>Prolonged large bowel transit time and an associated increase in the proportion of deoxycholic acid (DCA) in serum and bile have been implicated in the development of cholesterol-rich gallstones and colon cancer. Prolongation of interstional transit also increases intracolonic pH that, we hpothesized, should favor the solubilization and absorption of newly formed DCA within the colon.</abstract><cop>Bethesda, MD</cop><pub>American Physiological Society</pub></addata></record> |
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| identifier | ISSN: 0193-1857 |
| ispartof | American journal of physiology: Gastrointestinal and liver physiology, 2001-08, Vol.44 (2), p.G371-G374 |
| issn | 0193-1857 1522-1547 |
| language | eng |
| recordid | cdi_proquest_journals_232579963 |
| source | American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Bile Biological and medical sciences Cholesterol Colon Colorectal cancer Gallstones Gastroenterology. Liver. Pancreas. Abdomen Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Metabolism Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Influence of pH on the phase distribution of nascent deoxycholic acid in fresh human cecal aspirates |
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