Factors predicting for patient refusal of head and neck cancer therapy

Background The purpose of this study was to evaluate the national rate of treatment refusal in head and neck cancer (HNC). Methods The National Cancer Database was queried for nonmetastatic squamous cell carcinoma of the head and neck. Oncologic therapy referred to receipt of surgery, radiotherapy,...

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Veröffentlicht in:	Head & neck 2020-01, Vol.42 (1), p.33-42
Hauptverfasser:	Amini, Arya, Verma, Vivek, Li, Richard, Vora, Nayana, Kang, Robert, Gernon, Thomas J., Chang, Sue, Karam, Sana, Massarelli, Erminia, Maghami, Ellie G., Glaser, Scott
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Sprache:	eng
Schlagworte:	Cancer therapies Chemotherapy definitive treatment Head & neck cancer head and neck cancer Patients radiation Radiation therapy radiotherapy socioeconomic factors Squamous cell carcinoma Surgery treatment refusal
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container_title	Head & neck
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creator	Amini, Arya Verma, Vivek Li, Richard Vora, Nayana Kang, Robert Gernon, Thomas J. Chang, Sue Karam, Sana Massarelli, Erminia Maghami, Ellie G. Glaser, Scott
description	Background The purpose of this study was to evaluate the national rate of treatment refusal in head and neck cancer (HNC). Methods The National Cancer Database was queried for nonmetastatic squamous cell carcinoma of the head and neck. Oncologic therapy referred to receipt of surgery, radiotherapy, or chemotherapy. Results Compared to the 230 424 patients who received treatment, 2965 (1.3%) were reported to have refused definitive therapy. Predictors included older age, female sex, African‐American/other race, nonprivate insurance, greater comorbidities, more advanced disease, and residence closer to the treating facility (P
doi_str_mv	10.1002/hed.25966
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Methods The National Cancer Database was queried for nonmetastatic squamous cell carcinoma of the head and neck. Oncologic therapy referred to receipt of surgery, radiotherapy, or chemotherapy. Results Compared to the 230 424 patients who received treatment, 2965 (1.3%) were reported to have refused definitive therapy. Predictors included older age, female sex, African‐American/other race, nonprivate insurance, greater comorbidities, more advanced disease, and residence closer to the treating facility (P < .05). Patients with a prior history of cancer, Hispanic race, those treated at academic centers, and those from higher income counties were less likely to refuse therapy (P < .05). Patients who refused definitive therapy experienced poorer survival (median 79.1 vs 8.7 months, P < .001). Conclusions Refusing oncologic therapy is relatively rare in HNC and appears to be multifocal in nature.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25966</identifier><identifier>PMID: 31584746</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cancer therapies ; Chemotherapy ; definitive treatment ; Head & neck cancer ; head and neck cancer ; Patients ; radiation ; Radiation therapy ; radiotherapy ; socioeconomic factors ; Squamous cell carcinoma ; Surgery ; treatment refusal</subject><ispartof>Head & neck, 2020-01, Vol.42 (1), p.33-42</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4196-9a46318409e8f5d32388c015770a6cdd8a8187c6f8353a970c46937fa7bfba283</citedby><cites>FETCH-LOGICAL-c4196-9a46318409e8f5d32388c015770a6cdd8a8187c6f8353a970c46937fa7bfba283</cites><orcidid>0000-0002-6205-5969 ; 0000-0002-5863-6023</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25966$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25966$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31584746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amini, Arya</creatorcontrib><creatorcontrib>Verma, Vivek</creatorcontrib><creatorcontrib>Li, Richard</creatorcontrib><creatorcontrib>Vora, Nayana</creatorcontrib><creatorcontrib>Kang, Robert</creatorcontrib><creatorcontrib>Gernon, Thomas J.</creatorcontrib><creatorcontrib>Chang, Sue</creatorcontrib><creatorcontrib>Karam, Sana</creatorcontrib><creatorcontrib>Massarelli, Erminia</creatorcontrib><creatorcontrib>Maghami, Ellie G.</creatorcontrib><creatorcontrib>Glaser, Scott</creatorcontrib><title>Factors predicting for patient refusal of head and neck cancer therapy</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background The purpose of this study was to evaluate the national rate of treatment refusal in head and neck cancer (HNC). Methods The National Cancer Database was queried for nonmetastatic squamous cell carcinoma of the head and neck. Oncologic therapy referred to receipt of surgery, radiotherapy, or chemotherapy. Results Compared to the 230 424 patients who received treatment, 2965 (1.3%) were reported to have refused definitive therapy. Predictors included older age, female sex, African‐American/other race, nonprivate insurance, greater comorbidities, more advanced disease, and residence closer to the treating facility (P < .05). Patients with a prior history of cancer, Hispanic race, those treated at academic centers, and those from higher income counties were less likely to refuse therapy (P < .05). Patients who refused definitive therapy experienced poorer survival (median 79.1 vs 8.7 months, P < .001). Conclusions Refusing oncologic therapy is relatively rare in HNC and appears to be multifocal in nature.</description><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>definitive treatment</subject><subject>Head & neck cancer</subject><subject>head and neck cancer</subject><subject>Patients</subject><subject>radiation</subject><subject>Radiation therapy</subject><subject>radiotherapy</subject><subject>socioeconomic factors</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>treatment refusal</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOAjEUQBujEUQX_oBp4srFQF_Tx9IoiAmJG103l04rgzAztkMMf-_gwNJVb5qTc3MPQreUjCkhbLLyxZjlRsozNKTEqIxwoc4Ps-AZJ0oM0FVKa0IIl4JdogGnuRZKyCGazcC1dUy4ib4oXVtWnzjUETfQlr5qcfRhl2CD64BXHgoMVYEr776wg8r5iNuVj9Dsr9FFgE3yN8d3hD5m0_enebZ4e3l9elxkTlAjMwNCcqoFMV6HvOCMa-0IzZUiIF1RaNBUKyeD5jkHo4gT0nAVQC3DEpjmI3Tfe5tYf-98au263sWqW2kZZzljghvSUQ895WKdUneCbWK5hbi3lNhDMdsVs3_FOvbuaNwtt93viTwl6oBJD_yUG7__32Tn0-de-Qs9CHMV</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Amini, Arya</creator><creator>Verma, Vivek</creator><creator>Li, Richard</creator><creator>Vora, Nayana</creator><creator>Kang, Robert</creator><creator>Gernon, Thomas J.</creator><creator>Chang, Sue</creator><creator>Karam, Sana</creator><creator>Massarelli, Erminia</creator><creator>Maghami, Ellie G.</creator><creator>Glaser, Scott</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-6205-5969</orcidid><orcidid>https://orcid.org/0000-0002-5863-6023</orcidid></search><sort><creationdate>202001</creationdate><title>Factors predicting for patient refusal of head and neck cancer therapy</title><author>Amini, Arya ; Verma, Vivek ; Li, Richard ; Vora, Nayana ; Kang, Robert ; Gernon, Thomas J. ; Chang, Sue ; Karam, Sana ; Massarelli, Erminia ; Maghami, Ellie G. ; Glaser, Scott</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4196-9a46318409e8f5d32388c015770a6cdd8a8187c6f8353a970c46937fa7bfba283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>definitive treatment</topic><topic>Head & neck cancer</topic><topic>head and neck cancer</topic><topic>Patients</topic><topic>radiation</topic><topic>Radiation therapy</topic><topic>radiotherapy</topic><topic>socioeconomic factors</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>treatment refusal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amini, Arya</creatorcontrib><creatorcontrib>Verma, Vivek</creatorcontrib><creatorcontrib>Li, Richard</creatorcontrib><creatorcontrib>Vora, Nayana</creatorcontrib><creatorcontrib>Kang, Robert</creatorcontrib><creatorcontrib>Gernon, Thomas J.</creatorcontrib><creatorcontrib>Chang, Sue</creatorcontrib><creatorcontrib>Karam, Sana</creatorcontrib><creatorcontrib>Massarelli, Erminia</creatorcontrib><creatorcontrib>Maghami, Ellie G.</creatorcontrib><creatorcontrib>Glaser, Scott</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amini, Arya</au><au>Verma, Vivek</au><au>Li, Richard</au><au>Vora, Nayana</au><au>Kang, Robert</au><au>Gernon, Thomas J.</au><au>Chang, Sue</au><au>Karam, Sana</au><au>Massarelli, Erminia</au><au>Maghami, Ellie G.</au><au>Glaser, Scott</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors predicting for patient refusal of head and neck cancer therapy</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-01</date><risdate>2020</risdate><volume>42</volume><issue>1</issue><spage>33</spage><epage>42</epage><pages>33-42</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background The purpose of this study was to evaluate the national rate of treatment refusal in head and neck cancer (HNC). Methods The National Cancer Database was queried for nonmetastatic squamous cell carcinoma of the head and neck. Oncologic therapy referred to receipt of surgery, radiotherapy, or chemotherapy. Results Compared to the 230 424 patients who received treatment, 2965 (1.3%) were reported to have refused definitive therapy. Predictors included older age, female sex, African‐American/other race, nonprivate insurance, greater comorbidities, more advanced disease, and residence closer to the treating facility (P < .05). Patients with a prior history of cancer, Hispanic race, those treated at academic centers, and those from higher income counties were less likely to refuse therapy (P < .05). Patients who refused definitive therapy experienced poorer survival (median 79.1 vs 8.7 months, P < .001). Conclusions Refusing oncologic therapy is relatively rare in HNC and appears to be multifocal in nature.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>31584746</pmid><doi>10.1002/hed.25966</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6205-5969</orcidid><orcidid>https://orcid.org/0000-0002-5863-6023</orcidid></addata></record>
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subjects	Cancer therapies Chemotherapy definitive treatment Head & neck cancer head and neck cancer Patients radiation Radiation therapy radiotherapy socioeconomic factors Squamous cell carcinoma Surgery treatment refusal
title	Factors predicting for patient refusal of head and neck cancer therapy
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