The Reversed Clock Drawing Test Phenomenon in Alzheimer’s Disease: A Perfusion SPECT Study
Aim: To unveil a brain single photon emission computed tomography (SPECT) pattern in Alzheimer’s disease (AD) patients, showing a reversed clock drawing test (CDT) phenomenon. Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which...
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| Veröffentlicht in: | Dementia and geriatric cognitive disorders 2010-01, Vol.29 (1), p.1-10 |
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| creator | Brugnolo, A. Morbelli, S. Dessi, B. Girtler, N. Mazzei, D. Famà, F. Barbieri, P. Cabassi, G. Koulibaly, P.M. Sambuceti, G. Rodriguez, G. Nobili, F. |
| description | Aim: To unveil a brain single photon emission computed tomography (SPECT) pattern in Alzheimer’s disease (AD) patients, showing a reversed clock drawing test (CDT) phenomenon. Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which was analysed (SPM2) versus a group of 10 AD patients performing the CDT correctly (AD+) and versus 15 controls (CTR). Brain SPECT in 11 AD patients who mistook the CDT in a common way (AD–) was compared with AD+ and CTR groups. Results: Relative hypoperfusion was found in AD-R versus CTR in right medial frontal, parahippocampal and subcallosal gyri, and in left insula and superior temporal gyrus. Hypoperfusion was found in AD-R versus AD+ in the right uncus, superior temporal and parahippocampal gyri. In the AD– versus CTR comparison, hypoperfusion was found in left hippocampus, parahippocampal gyrus and superior parietal lobule. In AD-R versus AD+ and CTR merged together, the analysis showed hypoperfusion in the right parahippocampus, medial frontal gyrus, superior temporal gyrus and uncus, in the left insula and superior temporal gyrus. Conclusion: Fronto-temporal dysfunction, especially in the right hemisphere, plays a role in the reversed CDT phenomenon in AD patients, whereas matched AD patients mistaking the CDT in a common way show left posterior temporo-parietal hypoperfusion. |
| doi_str_mv | 10.1159/000270898 |
| format | Article |
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Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which was analysed (SPM2) versus a group of 10 AD patients performing the CDT correctly (AD+) and versus 15 controls (CTR). Brain SPECT in 11 AD patients who mistook the CDT in a common way (AD–) was compared with AD+ and CTR groups. Results: Relative hypoperfusion was found in AD-R versus CTR in right medial frontal, parahippocampal and subcallosal gyri, and in left insula and superior temporal gyrus. Hypoperfusion was found in AD-R versus AD+ in the right uncus, superior temporal and parahippocampal gyri. In the AD– versus CTR comparison, hypoperfusion was found in left hippocampus, parahippocampal gyrus and superior parietal lobule. In AD-R versus AD+ and CTR merged together, the analysis showed hypoperfusion in the right parahippocampus, medial frontal gyrus, superior temporal gyrus and uncus, in the left insula and superior temporal gyrus. Conclusion: Fronto-temporal dysfunction, especially in the right hemisphere, plays a role in the reversed CDT phenomenon in AD patients, whereas matched AD patients mistaking the CDT in a common way show left posterior temporo-parietal hypoperfusion.</description><identifier>ISSN: 1420-8008</identifier><identifier>EISSN: 1421-9824</identifier><identifier>DOI: 10.1159/000270898</identifier><identifier>PMID: 20093833</identifier><identifier>CODEN: DGCDFX</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Aged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - psychology ; Biological and medical sciences ; Brain - diagnostic imaging ; Cerebrovascular Circulation - physiology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Depression - psychology ; Executive Function ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nervous system ; Neurology ; Neuropsychological Tests ; Original Research Article ; Psychiatric Status Rating Scales ; Radionuclide Angiography ; Retrospective Studies ; Tomography, Emission-Computed, Single-Photon ; Ultrasonic investigative techniques</subject><ispartof>Dementia and geriatric cognitive disorders, 2010-01, Vol.29 (1), p.1-10</ispartof><rights>2010 S. Karger AG, Basel</rights><rights>2015 INIST-CNRS</rights><rights>2010 S. Karger AG, Basel.</rights><rights>Copyright (c) 2010 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-c03e1af78099430a6af935e421834a250666e37d5df971efddb1e86a98597c33</citedby><cites>FETCH-LOGICAL-c459t-c03e1af78099430a6af935e421834a250666e37d5df971efddb1e86a98597c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2430,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22473325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20093833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brugnolo, A.</creatorcontrib><creatorcontrib>Morbelli, S.</creatorcontrib><creatorcontrib>Dessi, B.</creatorcontrib><creatorcontrib>Girtler, N.</creatorcontrib><creatorcontrib>Mazzei, D.</creatorcontrib><creatorcontrib>Famà, F.</creatorcontrib><creatorcontrib>Barbieri, P.</creatorcontrib><creatorcontrib>Cabassi, G.</creatorcontrib><creatorcontrib>Koulibaly, P.M.</creatorcontrib><creatorcontrib>Sambuceti, G.</creatorcontrib><creatorcontrib>Rodriguez, G.</creatorcontrib><creatorcontrib>Nobili, F.</creatorcontrib><title>The Reversed Clock Drawing Test Phenomenon in Alzheimer’s Disease: A Perfusion SPECT Study</title><title>Dementia and geriatric cognitive disorders</title><addtitle>Dement Geriatr Cogn Disord</addtitle><description>Aim: To unveil a brain single photon emission computed tomography (SPECT) pattern in Alzheimer’s disease (AD) patients, showing a reversed clock drawing test (CDT) phenomenon. Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which was analysed (SPM2) versus a group of 10 AD patients performing the CDT correctly (AD+) and versus 15 controls (CTR). Brain SPECT in 11 AD patients who mistook the CDT in a common way (AD–) was compared with AD+ and CTR groups. Results: Relative hypoperfusion was found in AD-R versus CTR in right medial frontal, parahippocampal and subcallosal gyri, and in left insula and superior temporal gyrus. Hypoperfusion was found in AD-R versus AD+ in the right uncus, superior temporal and parahippocampal gyri. In the AD– versus CTR comparison, hypoperfusion was found in left hippocampus, parahippocampal gyrus and superior parietal lobule. In AD-R versus AD+ and CTR merged together, the analysis showed hypoperfusion in the right parahippocampus, medial frontal gyrus, superior temporal gyrus and uncus, in the left insula and superior temporal gyrus. Conclusion: Fronto-temporal dysfunction, especially in the right hemisphere, plays a role in the reversed CDT phenomenon in AD patients, whereas matched AD patients mistaking the CDT in a common way show left posterior temporo-parietal hypoperfusion.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - psychology</subject><subject>Biological and medical sciences</subject><subject>Brain - diagnostic imaging</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Leukodystrophies. Prion diseases</topic><topic>Depression - psychology</topic><topic>Executive Function</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Original Research Article</topic><topic>Psychiatric Status Rating Scales</topic><topic>Radionuclide Angiography</topic><topic>Retrospective Studies</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>Ultrasonic investigative techniques</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brugnolo, A.</creatorcontrib><creatorcontrib>Morbelli, S.</creatorcontrib><creatorcontrib>Dessi, B.</creatorcontrib><creatorcontrib>Girtler, N.</creatorcontrib><creatorcontrib>Mazzei, D.</creatorcontrib><creatorcontrib>Famà, F.</creatorcontrib><creatorcontrib>Barbieri, P.</creatorcontrib><creatorcontrib>Cabassi, G.</creatorcontrib><creatorcontrib>Koulibaly, P.M.</creatorcontrib><creatorcontrib>Sambuceti, G.</creatorcontrib><creatorcontrib>Rodriguez, G.</creatorcontrib><creatorcontrib>Nobili, F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Social Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Dementia and geriatric cognitive disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brugnolo, A.</au><au>Morbelli, S.</au><au>Dessi, B.</au><au>Girtler, N.</au><au>Mazzei, D.</au><au>Famà, F.</au><au>Barbieri, P.</au><au>Cabassi, G.</au><au>Koulibaly, P.M.</au><au>Sambuceti, G.</au><au>Rodriguez, G.</au><au>Nobili, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Reversed Clock Drawing Test Phenomenon in Alzheimer’s Disease: A Perfusion SPECT Study</atitle><jtitle>Dementia and geriatric cognitive disorders</jtitle><addtitle>Dement Geriatr Cogn Disord</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>29</volume><issue>1</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1420-8008</issn><eissn>1421-9824</eissn><coden>DGCDFX</coden><abstract>Aim: To unveil a brain single photon emission computed tomography (SPECT) pattern in Alzheimer’s disease (AD) patients, showing a reversed clock drawing test (CDT) phenomenon. Patients and Methods: Among 1,005 consecutive subjects, 9 AD patients who drew a reversed CDT (AD-R) underwent SPECT, which was analysed (SPM2) versus a group of 10 AD patients performing the CDT correctly (AD+) and versus 15 controls (CTR). Brain SPECT in 11 AD patients who mistook the CDT in a common way (AD–) was compared with AD+ and CTR groups. Results: Relative hypoperfusion was found in AD-R versus CTR in right medial frontal, parahippocampal and subcallosal gyri, and in left insula and superior temporal gyrus. Hypoperfusion was found in AD-R versus AD+ in the right uncus, superior temporal and parahippocampal gyri. In the AD– versus CTR comparison, hypoperfusion was found in left hippocampus, parahippocampal gyrus and superior parietal lobule. In AD-R versus AD+ and CTR merged together, the analysis showed hypoperfusion in the right parahippocampus, medial frontal gyrus, superior temporal gyrus and uncus, in the left insula and superior temporal gyrus. Conclusion: Fronto-temporal dysfunction, especially in the right hemisphere, plays a role in the reversed CDT phenomenon in AD patients, whereas matched AD patients mistaking the CDT in a common way show left posterior temporo-parietal hypoperfusion.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>20093833</pmid><doi>10.1159/000270898</doi><tpages>10</tpages></addata></record> |
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| subjects | Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - psychology Biological and medical sciences Brain - diagnostic imaging Cerebrovascular Circulation - physiology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Depression - psychology Executive Function Female Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Nervous system Neurology Neuropsychological Tests Original Research Article Psychiatric Status Rating Scales Radionuclide Angiography Retrospective Studies Tomography, Emission-Computed, Single-Photon Ultrasonic investigative techniques |
| title | The Reversed Clock Drawing Test Phenomenon in Alzheimer’s Disease: A Perfusion SPECT Study |
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