Cocoa ameliorates renal injury in Zucker diabetic fatty rats by preventing oxidative stress, apoptosis and inactivation of autophagy

Redox balance, autophagy and apoptosis are main processes involved in the development of diabetic nephropathy. Epidemiological and animal studies suggest that cocoa might reduce the risk of diabetic complications. However, the molecular mechanisms responsible for these potential preventive activitie...

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Veröffentlicht in:	Food & function 2019-12, Vol.1 (12), p.7926-7939
Hauptverfasser:	Álvarez-Cilleros, David, López-Oliva, María Elvira, Martín, María Ángeles, Ramos, Sonia
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP Animals Antioxidants Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Bax protein Bcl-x protein Beclin-1 - genetics Beclin-1 - metabolism Blood Glucose - metabolism Body weight Cacao - chemistry Carbonyl compounds Carbonyl groups Carbonyls Catalase Catalase - genetics Catalase - metabolism Cocoa Complications Deactivation Diabetes Diabetes mellitus Diabetes Mellitus - drug therapy Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetes Mellitus - physiopathology Diet Epidemiology Extracellular signal-regulated kinase Humans Inactivation Injury prevention Insulin Insulin - metabolism Kidney - drug effects Kidney - metabolism Kinases Male MAP kinase Molecular modelling NAD(P)H oxidase Nephropathy NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oxidative stress Oxidative Stress - drug effects Phagocytosis Protein kinase Proteins Rats Rats, Zucker Reactive oxygen species Renal function Risk reduction Rodents Signal transduction Signaling Stimulation Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism
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