MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway
This study aims to investigate whether microRNA (miR)-146a exerts therapeutic potential to allergic rhinitis (AR). Female BALB/c mice were randomly divided into the AR and miR-146a groups. miR-146a was administered into the nostril before ovalbumin (OVA) challenge daily on days 21–28. The expression...
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| Veröffentlicht in: | Immunotherapy 2019-09, Vol.11 (13), p.1095-1105 |
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| creator | Wang, Jia Cui, Zheqing Liu, Lei Zhang, Shitao Zhang, Yuan Zhang, Yujie Su, Hongxia Zhao, Yulin |
| description | This study aims to investigate whether microRNA (miR)-146a exerts therapeutic potential to allergic rhinitis (AR).
Female BALB/c mice were randomly divided into the AR and miR-146a groups. miR-146a was administered into the nostril before ovalbumin (OVA) challenge daily on days 21–28.
The expression level of miR-146a in AR nasal mucosa was significantly decreased. miR-146a mimic markedly attenuated sneezing and nasal rubbing events, decreased the levels of ovalbumin-specific IgE as well as mastocyte- and basophil-related inflammatory cytokines, reduced inflammatory cells, affected the T-helper 2-released cytokines. Furthermore, miR-146a mimic inhibited the expressions of proteins relevant to Toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway.
The anti-inflammatory effects of miR-146a on AR might exert through the inhibition of the toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway to some extent. |
| doi_str_mv | 10.2217/imt-2019-0047 |
| format | Article |
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Female BALB/c mice were randomly divided into the AR and miR-146a groups. miR-146a was administered into the nostril before ovalbumin (OVA) challenge daily on days 21–28.
The expression level of miR-146a in AR nasal mucosa was significantly decreased. miR-146a mimic markedly attenuated sneezing and nasal rubbing events, decreased the levels of ovalbumin-specific IgE as well as mastocyte- and basophil-related inflammatory cytokines, reduced inflammatory cells, affected the T-helper 2-released cytokines. Furthermore, miR-146a mimic inhibited the expressions of proteins relevant to Toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway.
The anti-inflammatory effects of miR-146a on AR might exert through the inhibition of the toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway to some extent.</description><identifier>ISSN: 1750-743X</identifier><identifier>EISSN: 1750-7448</identifier><identifier>DOI: 10.2217/imt-2019-0047</identifier><identifier>PMID: 31361168</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Allergens - immunology ; Allergic rhinitis ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Apoptosis ; Asthma ; Biomimetics - methods ; Cytokines ; Disease Models, Animal ; Female ; Genes ; Humans ; Immunoglobulin E ; Immunoglobulin E - blood ; Inflammation ; Kinases ; Laboratory animals ; Mice ; Mice, Inbred BALB C ; MicroRNAs ; MicroRNAs - genetics ; MicroRNAs - therapeutic use ; miR-146a ; miRNA ; Mucosa ; Nasal Mucosa - metabolism ; Nasal Mucosa - pathology ; NF-kappa B - metabolism ; NF-κB ; NF-κB protein ; Nose ; Ovalbumin ; Ovalbumin - immunology ; Pathogenesis ; Proteins ; Rheumatoid arthritis ; Rhinitis, Allergic - genetics ; Rhinitis, Allergic - therapy ; Signal Transduction ; TLR4 ; TLR4 protein ; TNF Receptor-Associated Factor 6 - metabolism ; Toll-Like Receptor 4 - metabolism ; Toll-like receptors ; TRAF6 ; TRAF6 protein</subject><ispartof>Immunotherapy, 2019-09, Vol.11 (13), p.1095-1105</ispartof><rights>2019 Future Medicine Ltd</rights><rights>Copyright Future Medicine Ltd Sep 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-96f42a586ff5c7c57a0dd7b4930d056de7cf170297637ef069bcce5e3ca18dcb3</citedby><cites>FETCH-LOGICAL-c371t-96f42a586ff5c7c57a0dd7b4930d056de7cf170297637ef069bcce5e3ca18dcb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31361168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Cui, Zheqing</creatorcontrib><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Zhang, Shitao</creatorcontrib><creatorcontrib>Zhang, Yuan</creatorcontrib><creatorcontrib>Zhang, Yujie</creatorcontrib><creatorcontrib>Su, Hongxia</creatorcontrib><creatorcontrib>Zhao, Yulin</creatorcontrib><title>MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway</title><title>Immunotherapy</title><addtitle>Immunotherapy</addtitle><description>This study aims to investigate whether microRNA (miR)-146a exerts therapeutic potential to allergic rhinitis (AR).
Female BALB/c mice were randomly divided into the AR and miR-146a groups. miR-146a was administered into the nostril before ovalbumin (OVA) challenge daily on days 21–28.
The expression level of miR-146a in AR nasal mucosa was significantly decreased. miR-146a mimic markedly attenuated sneezing and nasal rubbing events, decreased the levels of ovalbumin-specific IgE as well as mastocyte- and basophil-related inflammatory cytokines, reduced inflammatory cells, affected the T-helper 2-released cytokines. Furthermore, miR-146a mimic inhibited the expressions of proteins relevant to Toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway.
The anti-inflammatory effects of miR-146a on AR might exert through the inhibition of the toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway to some extent.</description><subject>Allergens - immunology</subject><subject>Allergic rhinitis</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Apoptosis</subject><subject>Asthma</subject><subject>Biomimetics - methods</subject><subject>Cytokines</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Genes</subject><subject>Humans</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Inflammation</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>MicroRNAs</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - therapeutic use</subject><subject>miR-146a</subject><subject>miRNA</subject><subject>Mucosa</subject><subject>Nasal Mucosa - metabolism</subject><subject>Nasal Mucosa - pathology</subject><subject>NF-kappa B - metabolism</subject><subject>NF-κB</subject><subject>NF-κB protein</subject><subject>Nose</subject><subject>Ovalbumin</subject><subject>Ovalbumin - immunology</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Rheumatoid arthritis</subject><subject>Rhinitis, Allergic - genetics</subject><subject>Rhinitis, Allergic - therapy</subject><subject>Signal Transduction</subject><subject>TLR4</subject><subject>TLR4 protein</subject><subject>TNF Receptor-Associated Factor 6 - metabolism</subject><subject>Toll-Like Receptor 4 - metabolism</subject><subject>Toll-like receptors</subject><subject>TRAF6</subject><subject>TRAF6 protein</subject><issn>1750-743X</issn><issn>1750-7448</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEFLwzAUx4Mobk6PXqXgOS5p0qQ9zuFUmApjgidDmqZbRtvNJGXsq_kh_ExmdO7mKS-83_s_3g-Aa4zu4hjzoak9jBHOIEKUn4A-5gmCnNL09FiTjx64cG6FEKOc0XPQI5gwjFnaB58vZgYxZTKqTW1UJL3XTSu9dlHdWtPoSFaVtovQskvTGG9clO-iYr1trF60lfSmWUTz6YwO57PRhA1fJ_Dn-z7aSL_cyt0lOCtl5fTV4R2A98nDfPwEp2-Pz-PRFCrCsYcZK2ksk5SVZaK4SrhERcFzmhFUoIQVmqsScxRnnBGuS8SyXCmdaKIkTguVkwG47XI3dv3VaufFat3aJqwUMYkJTcKxJFCwo5RdO2d1KTbW1NLuBEZib1MEm2JvU-xtBv7mkNrmtS6O9J--AGQdULa-tdopoxulRfcLE0YFg_-E_wLOTYPJ</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Wang, Jia</creator><creator>Cui, Zheqing</creator><creator>Liu, Lei</creator><creator>Zhang, Shitao</creator><creator>Zhang, Yuan</creator><creator>Zhang, Yujie</creator><creator>Su, Hongxia</creator><creator>Zhao, Yulin</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20190901</creationdate><title>MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway</title><author>Wang, Jia ; Cui, Zheqing ; Liu, Lei ; Zhang, Shitao ; Zhang, Yuan ; Zhang, Yujie ; Su, Hongxia ; Zhao, Yulin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-96f42a586ff5c7c57a0dd7b4930d056de7cf170297637ef069bcce5e3ca18dcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Allergens - immunology</topic><topic>Allergic rhinitis</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Apoptosis</topic><topic>Asthma</topic><topic>Biomimetics - methods</topic><topic>Cytokines</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Genes</topic><topic>Humans</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Inflammation</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>MicroRNAs</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - therapeutic use</topic><topic>miR-146a</topic><topic>miRNA</topic><topic>Mucosa</topic><topic>Nasal Mucosa - metabolism</topic><topic>Nasal Mucosa - pathology</topic><topic>NF-kappa B - metabolism</topic><topic>NF-κB</topic><topic>NF-κB protein</topic><topic>Nose</topic><topic>Ovalbumin</topic><topic>Ovalbumin - immunology</topic><topic>Pathogenesis</topic><topic>Proteins</topic><topic>Rheumatoid arthritis</topic><topic>Rhinitis, Allergic - genetics</topic><topic>Rhinitis, Allergic - therapy</topic><topic>Signal Transduction</topic><topic>TLR4</topic><topic>TLR4 protein</topic><topic>TNF Receptor-Associated Factor 6 - metabolism</topic><topic>Toll-Like Receptor 4 - metabolism</topic><topic>Toll-like receptors</topic><topic>TRAF6</topic><topic>TRAF6 protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jia</creatorcontrib><creatorcontrib>Cui, Zheqing</creatorcontrib><creatorcontrib>Liu, Lei</creatorcontrib><creatorcontrib>Zhang, Shitao</creatorcontrib><creatorcontrib>Zhang, Yuan</creatorcontrib><creatorcontrib>Zhang, Yujie</creatorcontrib><creatorcontrib>Su, Hongxia</creatorcontrib><creatorcontrib>Zhao, Yulin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Immunotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jia</au><au>Cui, Zheqing</au><au>Liu, Lei</au><au>Zhang, Shitao</au><au>Zhang, Yuan</au><au>Zhang, Yujie</au><au>Su, Hongxia</au><au>Zhao, Yulin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway</atitle><jtitle>Immunotherapy</jtitle><addtitle>Immunotherapy</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>11</volume><issue>13</issue><spage>1095</spage><epage>1105</epage><pages>1095-1105</pages><issn>1750-743X</issn><eissn>1750-7448</eissn><abstract>This study aims to investigate whether microRNA (miR)-146a exerts therapeutic potential to allergic rhinitis (AR).
Female BALB/c mice were randomly divided into the AR and miR-146a groups. miR-146a was administered into the nostril before ovalbumin (OVA) challenge daily on days 21–28.
The expression level of miR-146a in AR nasal mucosa was significantly decreased. miR-146a mimic markedly attenuated sneezing and nasal rubbing events, decreased the levels of ovalbumin-specific IgE as well as mastocyte- and basophil-related inflammatory cytokines, reduced inflammatory cells, affected the T-helper 2-released cytokines. Furthermore, miR-146a mimic inhibited the expressions of proteins relevant to Toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway.
The anti-inflammatory effects of miR-146a on AR might exert through the inhibition of the toll-like receptor 4 (TLR4)/TRAF6/NF-κB signaling pathway to some extent.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>31361168</pmid><doi>10.2217/imt-2019-0047</doi><tpages>11</tpages></addata></record> |
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| subjects | Allergens - immunology Allergic rhinitis Animals Anti-Inflammatory Agents - therapeutic use Apoptosis Asthma Biomimetics - methods Cytokines Disease Models, Animal Female Genes Humans Immunoglobulin E Immunoglobulin E - blood Inflammation Kinases Laboratory animals Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - genetics MicroRNAs - therapeutic use miR-146a miRNA Mucosa Nasal Mucosa - metabolism Nasal Mucosa - pathology NF-kappa B - metabolism NF-κB NF-κB protein Nose Ovalbumin Ovalbumin - immunology Pathogenesis Proteins Rheumatoid arthritis Rhinitis, Allergic - genetics Rhinitis, Allergic - therapy Signal Transduction TLR4 TLR4 protein TNF Receptor-Associated Factor 6 - metabolism Toll-Like Receptor 4 - metabolism Toll-like receptors TRAF6 TRAF6 protein |
| title | MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway |
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