Immunization with HER2 extracellular subdomain proteins induces cellular response and tumor growth inhibition in mice

We investigated cellular and protective immune responses in mice vaccinated with recombinant HER2 extracellular subdomains. Balb/C mice were immunized with recombinant full HER2 extracellular domain and subdomain proteins. Humoral and cellular immune response and antitumor effect was evaluated using...

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Veröffentlicht in:	IMMUNOTHERAPY 2018-05, Vol.10 (6), p.511-524
Hauptverfasser:	Ahmadi, Moslem, Sadri-Ardalani, Fateme, Amiri, Mohammad M, Jeddi-Tehrani, Mahmood, Shabani, Mahdi, Shokri, Fazel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor activity Breast cancer CpG islands cytokine Cytokines Dendritic cells ErbB-2 protein Helper cells HER2 Immune response (cell-mediated) Immune response (humoral) Immunization Immunoglobulins Immunotherapy Interleukin 17 Interleukin 4 Kinases Lymphocytes Lymphocytes T Medicin och hälsovetenskap Peptides protein immunization Proteins tumor challenge Tumors γ-Interferon
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