Pharmacokinetic dosing of aminoglycosides: a controlled trial

To evaluate whether individualized pharmacokinetic dosing of aminoglycosides can reduce nephrotoxicity and improve the outcome of patients with gram-negative sepsis. We conducted a prospective controlled trial at a tertiary care university hospital. Eighty-one patients with suspected or documented g...

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Veröffentlicht in:	The American journal of medicine 2003-02, Vol.114 (3), p.194-198
Hauptverfasser:	Bartal, Carmi, Danon, Abraham, Schlaeffer, Francisc, Reisenberg, Klaris, Alkan, Michael, Smoliakov, Rosa, Sidi, Aviel, Almog, Yaniv
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Amikacin - administration & dosage Amikacin - adverse effects Amikacin - pharmacokinetics Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - pharmacokinetics Bacteria Bacterial diseases Bacterial sepsis Biological and medical sciences Clinical outcomes Creatinine - blood Dose-Response Relationship, Drug Drug Administration Schedule Drug Monitoring - methods Drug therapy Drug toxicity and drugs side effects treatment Endpoint Determination Female Gentamicins - administration & dosage Gentamicins - adverse effects Gentamicins - pharmacokinetics Human bacterial diseases Humans Infections Infectious diseases Kidney Diseases - blood Kidney Diseases - chemically induced Male Medical sciences Middle Aged Pharmacology. Drug treatments Single-Blind Method Toxicity: urogenital system Treatment Outcome Tropical medicine
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