Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM)
Aims and objectives To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments. Background Oral anticancer therapy present challenges for pts since treatment is a home‐based therapy. This study evaluates t...
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| Veröffentlicht in: | Journal of clinical nursing 2020-01, Vol.29 (1-2), p.119-129 |
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| creator | Cirillo, Massimo Carlucci, Luciano Legramandi, Lorenzo Baldini, Editta Sacco, Cosimo Zagonel, Vittorina Leo, Silvana Di Fabio, Francesca Tonini, Giuseppe Meacci, Maria Luisa Tartarone, Alfredo Farci, Daniele Tortora, Giampaolo Zaninelli, Marta Valori, Vanna Maria Cinieri, Saverio Carrozza, Francesco Barbato, Enrico Fabbroni, Valentina Cretella, Elisabetta Gamucci, Teresa Lunardi, Gianluigi Zamboni, Sonia Micallo, Giovanni Cascinu, Stefano Pinto, Carmine Gori, Stefania |
| description | Aims and objectives
To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments.
Background
Oral anticancer therapy present challenges for pts since treatment is a home‐based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity.
Methods
This is an open‐label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0.
Results
Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3% vs. 21.6%, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3% vs. 23.8%, respectively).
Conclusions
Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results.
Relevance to clinical practice
Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring. |
| doi_str_mv | 10.1111/jocn.15064 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2323339420</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2323339420</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3574-cce646a1be59a9daf32e2a084e64b482178f4451297bf823fe9eace4583d74ec3</originalsourceid><addsrcrecordid>eNp9kcuOEzEQRS0EYjKBDR-ALLFhkHrwq1_soohH0Ay9gXWr2iknjhw72N1C_SX8Ls5kYEltSrp16tqqS8grzm55rveHoP0tL1mlnpAFl1VZiJqJp2TB2koUnFX1FblO6cAYl0LI5-RK8lIKJssF-d1FcBT8aDV4jZGOe4xwmukphgPq8QNdO-vz0NFptM6OMw2GAk0n1NZYTffhiFRDROqnmKzfnTd3EY5ZDp4OuAdnzjubEZwFT1cpBW1htHma5XvcPrh3XgcXdjN9u9p09zcvyDMDLuHLx74kPz59_L7-Utx1nzfr1V2hZVmrQmusVAV8wLKFdgtGChTAGpXlQTWC141RquSirQfTCGmwRdCoykZua4VaLsmbi2_-9c8J09gfwhR9frIXUkgpW5UPtSTvLpSOIaWIpj9Fe4Q495z15wz6cwb9QwYZfv1oOQ1H3P5D_x49A_wC_LIO5_9Y9V-79beL6R9KlpK3</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2323339420</pqid></control><display><type>article</type><title>Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM)</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Cirillo, Massimo ; Carlucci, Luciano ; Legramandi, Lorenzo ; Baldini, Editta ; Sacco, Cosimo ; Zagonel, Vittorina ; Leo, Silvana ; Di Fabio, Francesca ; Tonini, Giuseppe ; Meacci, Maria Luisa ; Tartarone, Alfredo ; Farci, Daniele ; Tortora, Giampaolo ; Zaninelli, Marta ; Valori, Vanna Maria ; Cinieri, Saverio ; Carrozza, Francesco ; Barbato, Enrico ; Fabbroni, Valentina ; Cretella, Elisabetta ; Gamucci, Teresa ; Lunardi, Gianluigi ; Zamboni, Sonia ; Micallo, Giovanni ; Cascinu, Stefano ; Pinto, Carmine ; Gori, Stefania</creator><creatorcontrib>Cirillo, Massimo ; Carlucci, Luciano ; Legramandi, Lorenzo ; Baldini, Editta ; Sacco, Cosimo ; Zagonel, Vittorina ; Leo, Silvana ; Di Fabio, Francesca ; Tonini, Giuseppe ; Meacci, Maria Luisa ; Tartarone, Alfredo ; Farci, Daniele ; Tortora, Giampaolo ; Zaninelli, Marta ; Valori, Vanna Maria ; Cinieri, Saverio ; Carrozza, Francesco ; Barbato, Enrico ; Fabbroni, Valentina ; Cretella, Elisabetta ; Gamucci, Teresa ; Lunardi, Gianluigi ; Zamboni, Sonia ; Micallo, Giovanni ; Cascinu, Stefano ; Pinto, Carmine ; Gori, Stefania</creatorcontrib><description>Aims and objectives
To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments.
Background
Oral anticancer therapy present challenges for pts since treatment is a home‐based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity.
Methods
This is an open‐label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0.
Results
Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3% vs. 21.6%, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3% vs. 23.8%, respectively).
Conclusions
Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results.
Relevance to clinical practice
Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring.</description><identifier>ISSN: 0962-1067</identifier><identifier>EISSN: 1365-2702</identifier><identifier>DOI: 10.1111/jocn.15064</identifier><identifier>PMID: 31532035</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Administration, Oral ; Antineoplastic Agents - administration & dosage ; Cancer ; Chemotherapy ; Clinical trials ; Cytotoxicity ; Drug administration ; Drug dosages ; Female ; Home Care Services - organization & administration ; Home health care ; Humans ; Italy ; Male ; Medical Oncology - organization & administration ; Middle Aged ; Neoplasms - drug therapy ; Neoplasms - nursing ; nurse monitoring ; Nursing care ; Oncology Nursing - organization & administration ; oral anticancer therapy ; Oral cancer ; Patient admissions ; patient education ; Quality of care ; Therapeutics</subject><ispartof>Journal of clinical nursing, 2020-01, Vol.29 (1-2), p.119-129</ispartof><rights>2019 John Wiley & Sons Ltd</rights><rights>2019 John Wiley & Sons Ltd.</rights><rights>Copyright © 2020 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-cce646a1be59a9daf32e2a084e64b482178f4451297bf823fe9eace4583d74ec3</citedby><cites>FETCH-LOGICAL-c3574-cce646a1be59a9daf32e2a084e64b482178f4451297bf823fe9eace4583d74ec3</cites><orcidid>0000-0002-6208-4620</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjocn.15064$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjocn.15064$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31532035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cirillo, Massimo</creatorcontrib><creatorcontrib>Carlucci, Luciano</creatorcontrib><creatorcontrib>Legramandi, Lorenzo</creatorcontrib><creatorcontrib>Baldini, Editta</creatorcontrib><creatorcontrib>Sacco, Cosimo</creatorcontrib><creatorcontrib>Zagonel, Vittorina</creatorcontrib><creatorcontrib>Leo, Silvana</creatorcontrib><creatorcontrib>Di Fabio, Francesca</creatorcontrib><creatorcontrib>Tonini, Giuseppe</creatorcontrib><creatorcontrib>Meacci, Maria Luisa</creatorcontrib><creatorcontrib>Tartarone, Alfredo</creatorcontrib><creatorcontrib>Farci, Daniele</creatorcontrib><creatorcontrib>Tortora, Giampaolo</creatorcontrib><creatorcontrib>Zaninelli, Marta</creatorcontrib><creatorcontrib>Valori, Vanna Maria</creatorcontrib><creatorcontrib>Cinieri, Saverio</creatorcontrib><creatorcontrib>Carrozza, Francesco</creatorcontrib><creatorcontrib>Barbato, Enrico</creatorcontrib><creatorcontrib>Fabbroni, Valentina</creatorcontrib><creatorcontrib>Cretella, Elisabetta</creatorcontrib><creatorcontrib>Gamucci, Teresa</creatorcontrib><creatorcontrib>Lunardi, Gianluigi</creatorcontrib><creatorcontrib>Zamboni, Sonia</creatorcontrib><creatorcontrib>Micallo, Giovanni</creatorcontrib><creatorcontrib>Cascinu, Stefano</creatorcontrib><creatorcontrib>Pinto, Carmine</creatorcontrib><creatorcontrib>Gori, Stefania</creatorcontrib><title>Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM)</title><title>Journal of clinical nursing</title><addtitle>J Clin Nurs</addtitle><description>Aims and objectives
To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments.
Background
Oral anticancer therapy present challenges for pts since treatment is a home‐based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity.
Methods
This is an open‐label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0.
Results
Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3% vs. 21.6%, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3% vs. 23.8%, respectively).
Conclusions
Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results.
Relevance to clinical practice
Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring.</description><subject>Administration, Oral</subject><subject>Antineoplastic Agents - administration & dosage</subject><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Clinical trials</subject><subject>Cytotoxicity</subject><subject>Drug administration</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Home Care Services - organization & administration</subject><subject>Home health care</subject><subject>Humans</subject><subject>Italy</subject><subject>Male</subject><subject>Medical Oncology - organization & administration</subject><subject>Middle Aged</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - nursing</subject><subject>nurse monitoring</subject><subject>Nursing care</subject><subject>Oncology Nursing - organization & administration</subject><subject>oral anticancer therapy</subject><subject>Oral cancer</subject><subject>Patient admissions</subject><subject>patient education</subject><subject>Quality of care</subject><subject>Therapeutics</subject><issn>0962-1067</issn><issn>1365-2702</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuOEzEQRS0EYjKBDR-ALLFhkHrwq1_soohH0Ay9gXWr2iknjhw72N1C_SX8Ls5kYEltSrp16tqqS8grzm55rveHoP0tL1mlnpAFl1VZiJqJp2TB2koUnFX1FblO6cAYl0LI5-RK8lIKJssF-d1FcBT8aDV4jZGOe4xwmukphgPq8QNdO-vz0NFptM6OMw2GAk0n1NZYTffhiFRDROqnmKzfnTd3EY5ZDp4OuAdnzjubEZwFT1cpBW1htHma5XvcPrh3XgcXdjN9u9p09zcvyDMDLuHLx74kPz59_L7-Utx1nzfr1V2hZVmrQmusVAV8wLKFdgtGChTAGpXlQTWC141RquSirQfTCGmwRdCoykZua4VaLsmbi2_-9c8J09gfwhR9frIXUkgpW5UPtSTvLpSOIaWIpj9Fe4Q495z15wz6cwb9QwYZfv1oOQ1H3P5D_x49A_wC_LIO5_9Y9V-79beL6R9KlpK3</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Cirillo, Massimo</creator><creator>Carlucci, Luciano</creator><creator>Legramandi, Lorenzo</creator><creator>Baldini, Editta</creator><creator>Sacco, Cosimo</creator><creator>Zagonel, Vittorina</creator><creator>Leo, Silvana</creator><creator>Di Fabio, Francesca</creator><creator>Tonini, Giuseppe</creator><creator>Meacci, Maria Luisa</creator><creator>Tartarone, Alfredo</creator><creator>Farci, Daniele</creator><creator>Tortora, Giampaolo</creator><creator>Zaninelli, Marta</creator><creator>Valori, Vanna Maria</creator><creator>Cinieri, Saverio</creator><creator>Carrozza, Francesco</creator><creator>Barbato, Enrico</creator><creator>Fabbroni, Valentina</creator><creator>Cretella, Elisabetta</creator><creator>Gamucci, Teresa</creator><creator>Lunardi, Gianluigi</creator><creator>Zamboni, Sonia</creator><creator>Micallo, Giovanni</creator><creator>Cascinu, Stefano</creator><creator>Pinto, Carmine</creator><creator>Gori, Stefania</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-6208-4620</orcidid></search><sort><creationdate>202001</creationdate><title>Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM)</title><author>Cirillo, Massimo ; Carlucci, Luciano ; Legramandi, Lorenzo ; Baldini, Editta ; Sacco, Cosimo ; Zagonel, Vittorina ; Leo, Silvana ; Di Fabio, Francesca ; Tonini, Giuseppe ; Meacci, Maria Luisa ; Tartarone, Alfredo ; Farci, Daniele ; Tortora, Giampaolo ; Zaninelli, Marta ; Valori, Vanna Maria ; Cinieri, Saverio ; Carrozza, Francesco ; Barbato, Enrico ; Fabbroni, Valentina ; Cretella, Elisabetta ; Gamucci, Teresa ; Lunardi, Gianluigi ; Zamboni, Sonia ; Micallo, Giovanni ; Cascinu, Stefano ; Pinto, Carmine ; Gori, Stefania</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-cce646a1be59a9daf32e2a084e64b482178f4451297bf823fe9eace4583d74ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Oral</topic><topic>Antineoplastic Agents - administration & dosage</topic><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Clinical trials</topic><topic>Cytotoxicity</topic><topic>Drug administration</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Home Care Services - organization & administration</topic><topic>Home health care</topic><topic>Humans</topic><topic>Italy</topic><topic>Male</topic><topic>Medical Oncology - organization & administration</topic><topic>Middle Aged</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - nursing</topic><topic>nurse monitoring</topic><topic>Nursing care</topic><topic>Oncology Nursing - organization & administration</topic><topic>oral anticancer therapy</topic><topic>Oral cancer</topic><topic>Patient admissions</topic><topic>patient education</topic><topic>Quality of care</topic><topic>Therapeutics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cirillo, Massimo</creatorcontrib><creatorcontrib>Carlucci, Luciano</creatorcontrib><creatorcontrib>Legramandi, Lorenzo</creatorcontrib><creatorcontrib>Baldini, Editta</creatorcontrib><creatorcontrib>Sacco, Cosimo</creatorcontrib><creatorcontrib>Zagonel, Vittorina</creatorcontrib><creatorcontrib>Leo, Silvana</creatorcontrib><creatorcontrib>Di Fabio, Francesca</creatorcontrib><creatorcontrib>Tonini, Giuseppe</creatorcontrib><creatorcontrib>Meacci, Maria Luisa</creatorcontrib><creatorcontrib>Tartarone, Alfredo</creatorcontrib><creatorcontrib>Farci, Daniele</creatorcontrib><creatorcontrib>Tortora, Giampaolo</creatorcontrib><creatorcontrib>Zaninelli, Marta</creatorcontrib><creatorcontrib>Valori, Vanna Maria</creatorcontrib><creatorcontrib>Cinieri, Saverio</creatorcontrib><creatorcontrib>Carrozza, Francesco</creatorcontrib><creatorcontrib>Barbato, Enrico</creatorcontrib><creatorcontrib>Fabbroni, Valentina</creatorcontrib><creatorcontrib>Cretella, Elisabetta</creatorcontrib><creatorcontrib>Gamucci, Teresa</creatorcontrib><creatorcontrib>Lunardi, Gianluigi</creatorcontrib><creatorcontrib>Zamboni, Sonia</creatorcontrib><creatorcontrib>Micallo, Giovanni</creatorcontrib><creatorcontrib>Cascinu, Stefano</creatorcontrib><creatorcontrib>Pinto, Carmine</creatorcontrib><creatorcontrib>Gori, Stefania</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Journal of clinical nursing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cirillo, Massimo</au><au>Carlucci, Luciano</au><au>Legramandi, Lorenzo</au><au>Baldini, Editta</au><au>Sacco, Cosimo</au><au>Zagonel, Vittorina</au><au>Leo, Silvana</au><au>Di Fabio, Francesca</au><au>Tonini, Giuseppe</au><au>Meacci, Maria Luisa</au><au>Tartarone, Alfredo</au><au>Farci, Daniele</au><au>Tortora, Giampaolo</au><au>Zaninelli, Marta</au><au>Valori, Vanna Maria</au><au>Cinieri, Saverio</au><au>Carrozza, Francesco</au><au>Barbato, Enrico</au><au>Fabbroni, Valentina</au><au>Cretella, Elisabetta</au><au>Gamucci, Teresa</au><au>Lunardi, Gianluigi</au><au>Zamboni, Sonia</au><au>Micallo, Giovanni</au><au>Cascinu, Stefano</au><au>Pinto, Carmine</au><au>Gori, Stefania</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM)</atitle><jtitle>Journal of clinical nursing</jtitle><addtitle>J Clin Nurs</addtitle><date>2020-01</date><risdate>2020</risdate><volume>29</volume><issue>1-2</issue><spage>119</spage><epage>129</epage><pages>119-129</pages><issn>0962-1067</issn><eissn>1365-2702</eissn><abstract>Aims and objectives
To assess the effectiveness of a specific home care nursing programme in addition to standard care in patients (pts) receiving oral anticancer treatments.
Background
Oral anticancer therapy present challenges for pts since treatment is a home‐based therapy. This study evaluates the potentiality of a home care nursing programme in decreasing hospital accesses for not severe toxicity.
Methods
This is an open‐label, multicentre, randomised trial including pts who were receiving an anticancer oral drug. The study complies with the CONSORT checklist published in 2010. Concomitant use of radiation therapy, intravenous or metronomic therapies, or the intake of previous oral drugs was not allowed. Pts were randomly assigned to home care nursing programme (A) or standard care (B). In arm A, dedicated nurses provided information to pts, a daily record on which pts would take note of drugs and dosages and a telephone monitoring during the first two cycles of therapy. The primary outcome was the reduction in improper hospital accesses for grade 1–2 toxicity according to CTCAE v4.0.
Results
Out of 432 randomised pts, 378 were analysed (184 pts in arm A and 194 in arm B). Hospital accesses were observed in 41 pts in arm A and in 42 pts in arm B (22.3% vs. 21.6%, respectively). No difference was detected in proportion of improper accesses between arm A and arm B (29.3% vs. 23.8%, respectively).
Conclusions
Our experience failed to support the role of a specific home care nursing programme for pts taking oral chemotherapy. An improved attention to specific educational practice and information offered to pts can explain these results.
Relevance to clinical practice
Our results underline the role of nurse educational practice and information offered to patients. A careful nurse information of patients about drugs is essential to reduce toxicities avoiding the opportunity of a specific home monitoring.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31532035</pmid><doi>10.1111/jocn.15064</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6208-4620</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0962-1067 |
| ispartof | Journal of clinical nursing, 2020-01, Vol.29 (1-2), p.119-129 |
| issn | 0962-1067 1365-2702 |
| language | eng |
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| source | MEDLINE; Wiley Journals |
| subjects | Administration, Oral Antineoplastic Agents - administration & dosage Cancer Chemotherapy Clinical trials Cytotoxicity Drug administration Drug dosages Female Home Care Services - organization & administration Home health care Humans Italy Male Medical Oncology - organization & administration Middle Aged Neoplasms - drug therapy Neoplasms - nursing nurse monitoring Nursing care Oncology Nursing - organization & administration oral anticancer therapy Oral cancer Patient admissions patient education Quality of care Therapeutics |
| title | Oral anticancer therapy project: Clinical utility of a specific home care nursing programme on behalf of Italian Association of Medical Oncology (AIOM) |
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