Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion

The importance of mitochondrial biosynthesis in stimulus secretion coupling in the insulin-producing {beta}-cell probably equals that of ATP production. In glucose-induced insulin secretion, the rate of pyruvate carboxylation is very high and correlates more strongly with the glucose concentration t...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2005, Vol.51 (1), p.E1-E15
Hauptverfasser:	MACDONALD, Michael J, FAHIEN, Leonard A, BROWN, Laura J, HASAN, Noaman M, BUSS, Julian D, KENDRICK, Mindy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase Biological and medical sciences Cells Enzymes Fundamental and applied biological sciences. Psychology Insulin Mitochondrial DNA Vertebrates: endocrinology
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