Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis
1 Université Montpellier 1, UFR Médecine EA701, F-34295, Montpellier; 2 Institut National de la Santé et de la Recherche, ERI 25, F-34295, Montpellier; 3 Université Evry Val d'Essonne, UFR Sciences fondamentales et appliquées, EA3872, Département Sciences et Techniques des Activités Physiques e...
Gespeichert in:
| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2007-10, Vol.293 (4), p.E916-E922 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | E922 |
|---|---|
| container_issue | 4 |
| container_start_page | E916 |
| container_title | American journal of physiology: endocrinology and metabolism |
| container_volume | 293 |
| creator | Thomas, Claire Bishop, David Moore-Morris, Tom Mercier, Jacques |
| description | 1 Université Montpellier 1, UFR Médecine EA701, F-34295, Montpellier; 2 Institut National de la Santé et de la Recherche, ERI 25, F-34295, Montpellier; 3 Université Evry Val d'Essonne, UFR Sciences fondamentales et appliquées, EA3872, Département Sciences et Techniques des Activités Physiques et Sportives, F-91025, Evry, France; and 4 Facoltà di Scienze Motorie, Università degli Studi di Verona, Verona, Italy
Submitted 13 March 2007
; accepted in final form 28 June 2007
This study investigated the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles. Male Wistar rats performed high-intensity training on a treadmill 5 times/wk for 5 wk, receiving either sodium bicarbonate (ALK-T) or a placebo (PLA-T) prior to each training session, and were compared with a group of control rats (CON). MCT1, MCT4, and NBC content was measured by Western blotting in soleus and extensor digitorum longus (EDL) skeletal muscles. Citrate synthase (CS) and phosphofructokinase (PFK) activities and muscle buffer capacity ( m) were also evaluated. Following training, CS and PFK activities were significantly higher in the soleus only ( P < 0.05), whereas m was significantly higher in both soleus and EDL ( P < 0.05). MCT1 (PLA-T: 30%; ALK-T: 23%) and NBC contents (PLA-T: 85%; ALK-T: 60%) increased significantly only in the soleus following training ( P < 0.01). MCT4 content in the soleus was significantly greater in ALK-T (115%) but not PLA-T compared with CON. There was no significant change in protein content in the EDL. Finally, NBC content was related only to MCT1 content in soleus ( r = 0.50, P < 0.01). In conclusion, these results suggest that MCT1, MCT4, and NBC undergo fiber-specific adaptive changes in response to high-intensity training and that induced alkalosis has a positive effect on training-induced changes in MCT4 content. The correlation between MCT1 and NBC expression suggests that lactate transport may be facilitated by NBC in oxidative skeletal muscle, which may in turn favor better muscle pH regulation.
monocarboxylate transporter; sodium bicarbonate transporter; lactate transporter; muscle pH regulation; exercise
Address for reprint requests and other correspondence: C. Thomas, Université d'Evry Val d'Essonne, Département STAPS, UFR des Sciences fondamentales et appliquées, Laboratoire d'Etude de la Physiologie de l'Exercice |
| doi_str_mv | 10.1152/ajpendo.00164.2007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_highw</sourceid><recordid>TN_cdi_proquest_journals_232315358</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1361789471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c591t-68415dcbaff457930c23a0a2e9fdde1f5cfaf9064195d34eeeea89f0513070bf3</originalsourceid><addsrcrecordid>eNp1kc1uEzEURkcIRNPCC7BAFgukSp3gn_FMzK5EKUUKsAlry_FcJ04de7BnoHkCXhsPCa2EhBe2ZZ_vXl2donhF8JQQTt-pXQe-DVOMSV1NKcbNk2KSP2hJOOdPiwkmgpVkVomz4jylHc4Er-jz4ow0NRaUN5Pi18IY0H1CwaCt3WxL63vwyfYH1EdlvfUbFDz6PF-Rq3GvrpDyLfryYY7gvouQkg0-IetRVD1Kd-CgVw7th6QdpPf5w7gBvIaxgd7G4K1G-8ysg8s35e6UC8mmF8Uzo1yCl6fzovh2s1jNb8vl14-f5tfLUnNB-rKeVYS3eq2MqXgjGNaUKawoCNO2QAzXRhmB64oI3rIK8lIzYTAnDDd4bdhFcXmsu1VOdtHuVTzIoKy8vV7K8Q0TPmtqWv8gmX17ZLsYvg-Qerm3SYNzykMYkqSYNqwmswy--QfchSH6PIekjDLCGR8heoR0DClFMA_tCZajT3nyKf_4lKPPHHp9qjys99A-Rk4CM1Ce5snyftoIstseshMXNoeHglQwWcmFIHXmxf_5m8G5Fdz3f4OPOdm1hv0GzjnCQw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>232315358</pqid></control><display><type>article</type><title>Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis</title><source>MEDLINE</source><source>American Physiological Society</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Thomas, Claire ; Bishop, David ; Moore-Morris, Tom ; Mercier, Jacques</creator><creatorcontrib>Thomas, Claire ; Bishop, David ; Moore-Morris, Tom ; Mercier, Jacques</creatorcontrib><description>1 Université Montpellier 1, UFR Médecine EA701, F-34295, Montpellier; 2 Institut National de la Santé et de la Recherche, ERI 25, F-34295, Montpellier; 3 Université Evry Val d'Essonne, UFR Sciences fondamentales et appliquées, EA3872, Département Sciences et Techniques des Activités Physiques et Sportives, F-91025, Evry, France; and 4 Facoltà di Scienze Motorie, Università degli Studi di Verona, Verona, Italy
Submitted 13 March 2007
; accepted in final form 28 June 2007
This study investigated the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles. Male Wistar rats performed high-intensity training on a treadmill 5 times/wk for 5 wk, receiving either sodium bicarbonate (ALK-T) or a placebo (PLA-T) prior to each training session, and were compared with a group of control rats (CON). MCT1, MCT4, and NBC content was measured by Western blotting in soleus and extensor digitorum longus (EDL) skeletal muscles. Citrate synthase (CS) and phosphofructokinase (PFK) activities and muscle buffer capacity ( m) were also evaluated. Following training, CS and PFK activities were significantly higher in the soleus only ( P < 0.05), whereas m was significantly higher in both soleus and EDL ( P < 0.05). MCT1 (PLA-T: 30%; ALK-T: 23%) and NBC contents (PLA-T: 85%; ALK-T: 60%) increased significantly only in the soleus following training ( P < 0.01). MCT4 content in the soleus was significantly greater in ALK-T (115%) but not PLA-T compared with CON. There was no significant change in protein content in the EDL. Finally, NBC content was related only to MCT1 content in soleus ( r = 0.50, P < 0.01). In conclusion, these results suggest that MCT1, MCT4, and NBC undergo fiber-specific adaptive changes in response to high-intensity training and that induced alkalosis has a positive effect on training-induced changes in MCT4 content. The correlation between MCT1 and NBC expression suggests that lactate transport may be facilitated by NBC in oxidative skeletal muscle, which may in turn favor better muscle pH regulation.
monocarboxylate transporter; sodium bicarbonate transporter; lactate transporter; muscle pH regulation; exercise
Address for reprint requests and other correspondence: C. Thomas, Université d'Evry Val d'Essonne, Département STAPS, UFR des Sciences fondamentales et appliquées, Laboratoire d'Etude de la Physiologie de l'Exercice (EA 3872), Bvd François Mitterrand, 91025 Evry Cedex, France (e-mail: thomasclaire{at}wanadoo.fr )</description><identifier>ISSN: 0193-1849</identifier><identifier>EISSN: 1522-1555</identifier><identifier>DOI: 10.1152/ajpendo.00164.2007</identifier><identifier>PMID: 17609257</identifier><identifier>CODEN: AJPMD9</identifier><language>eng</language><publisher>United States: American Physiological Society</publisher><subject>Alkalosis - chemically induced ; Alkalosis - metabolism ; Animals ; Chronic Disease ; Citrate (si)-Synthase - metabolism ; Gene expression ; Kinases ; Lactic Acid - metabolism ; Life Sciences ; Male ; Metabolism ; Monocarboxylic Acid Transporters - metabolism ; Muscle Proteins - metabolism ; Muscle, Skeletal - metabolism ; Musculoskeletal system ; Phosphofructokinase-1 - metabolism ; Physical Conditioning, Animal - physiology ; Physical Exertion - physiology ; Proteins ; Rats ; Rats, Wistar ; Rodents ; Sodium Bicarbonate ; Sodium-Bicarbonate Symporters - metabolism ; Studies ; Symporters - metabolism</subject><ispartof>American journal of physiology: endocrinology and metabolism, 2007-10, Vol.293 (4), p.E916-E922</ispartof><rights>Copyright American Physiological Society Oct 2007</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-68415dcbaff457930c23a0a2e9fdde1f5cfaf9064195d34eeeea89f0513070bf3</citedby><cites>FETCH-LOGICAL-c591t-68415dcbaff457930c23a0a2e9fdde1f5cfaf9064195d34eeeea89f0513070bf3</cites><orcidid>0000-0001-7583-1069 ; 0000-0002-4611-042X ; 0000-0002-5037-2430</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,3026,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17609257$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://insep.hal.science/hal-01587626$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Thomas, Claire</creatorcontrib><creatorcontrib>Bishop, David</creatorcontrib><creatorcontrib>Moore-Morris, Tom</creatorcontrib><creatorcontrib>Mercier, Jacques</creatorcontrib><title>Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis</title><title>American journal of physiology: endocrinology and metabolism</title><addtitle>Am J Physiol Endocrinol Metab</addtitle><description>1 Université Montpellier 1, UFR Médecine EA701, F-34295, Montpellier; 2 Institut National de la Santé et de la Recherche, ERI 25, F-34295, Montpellier; 3 Université Evry Val d'Essonne, UFR Sciences fondamentales et appliquées, EA3872, Département Sciences et Techniques des Activités Physiques et Sportives, F-91025, Evry, France; and 4 Facoltà di Scienze Motorie, Università degli Studi di Verona, Verona, Italy
Submitted 13 March 2007
; accepted in final form 28 June 2007
This study investigated the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles. Male Wistar rats performed high-intensity training on a treadmill 5 times/wk for 5 wk, receiving either sodium bicarbonate (ALK-T) or a placebo (PLA-T) prior to each training session, and were compared with a group of control rats (CON). MCT1, MCT4, and NBC content was measured by Western blotting in soleus and extensor digitorum longus (EDL) skeletal muscles. Citrate synthase (CS) and phosphofructokinase (PFK) activities and muscle buffer capacity ( m) were also evaluated. Following training, CS and PFK activities were significantly higher in the soleus only ( P < 0.05), whereas m was significantly higher in both soleus and EDL ( P < 0.05). MCT1 (PLA-T: 30%; ALK-T: 23%) and NBC contents (PLA-T: 85%; ALK-T: 60%) increased significantly only in the soleus following training ( P < 0.01). MCT4 content in the soleus was significantly greater in ALK-T (115%) but not PLA-T compared with CON. There was no significant change in protein content in the EDL. Finally, NBC content was related only to MCT1 content in soleus ( r = 0.50, P < 0.01). In conclusion, these results suggest that MCT1, MCT4, and NBC undergo fiber-specific adaptive changes in response to high-intensity training and that induced alkalosis has a positive effect on training-induced changes in MCT4 content. The correlation between MCT1 and NBC expression suggests that lactate transport may be facilitated by NBC in oxidative skeletal muscle, which may in turn favor better muscle pH regulation.
monocarboxylate transporter; sodium bicarbonate transporter; lactate transporter; muscle pH regulation; exercise
Address for reprint requests and other correspondence: C. Thomas, Université d'Evry Val d'Essonne, Département STAPS, UFR des Sciences fondamentales et appliquées, Laboratoire d'Etude de la Physiologie de l'Exercice (EA 3872), Bvd François Mitterrand, 91025 Evry Cedex, France (e-mail: thomasclaire{at}wanadoo.fr )</description><subject>Alkalosis - chemically induced</subject><subject>Alkalosis - metabolism</subject><subject>Animals</subject><subject>Chronic Disease</subject><subject>Citrate (si)-Synthase - metabolism</subject><subject>Gene expression</subject><subject>Kinases</subject><subject>Lactic Acid - metabolism</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Metabolism</subject><subject>Monocarboxylic Acid Transporters - metabolism</subject><subject>Muscle Proteins - metabolism</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Musculoskeletal system</subject><subject>Phosphofructokinase-1 - metabolism</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical Exertion - physiology</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sodium Bicarbonate</subject><subject>Sodium-Bicarbonate Symporters - metabolism</subject><subject>Studies</subject><subject>Symporters - metabolism</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1uEzEURkcIRNPCC7BAFgukSp3gn_FMzK5EKUUKsAlry_FcJ04de7BnoHkCXhsPCa2EhBe2ZZ_vXl2donhF8JQQTt-pXQe-DVOMSV1NKcbNk2KSP2hJOOdPiwkmgpVkVomz4jylHc4Er-jz4ow0NRaUN5Pi18IY0H1CwaCt3WxL63vwyfYH1EdlvfUbFDz6PF-Rq3GvrpDyLfryYY7gvouQkg0-IetRVD1Kd-CgVw7th6QdpPf5w7gBvIaxgd7G4K1G-8ysg8s35e6UC8mmF8Uzo1yCl6fzovh2s1jNb8vl14-f5tfLUnNB-rKeVYS3eq2MqXgjGNaUKawoCNO2QAzXRhmB64oI3rIK8lIzYTAnDDd4bdhFcXmsu1VOdtHuVTzIoKy8vV7K8Q0TPmtqWv8gmX17ZLsYvg-Qerm3SYNzykMYkqSYNqwmswy--QfchSH6PIekjDLCGR8heoR0DClFMA_tCZajT3nyKf_4lKPPHHp9qjys99A-Rk4CM1Ce5snyftoIstseshMXNoeHglQwWcmFIHXmxf_5m8G5Fdz3f4OPOdm1hv0GzjnCQw</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Thomas, Claire</creator><creator>Bishop, David</creator><creator>Moore-Morris, Tom</creator><creator>Mercier, Jacques</creator><general>American Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TS</scope><scope>7U7</scope><scope>C1K</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-7583-1069</orcidid><orcidid>https://orcid.org/0000-0002-4611-042X</orcidid><orcidid>https://orcid.org/0000-0002-5037-2430</orcidid></search><sort><creationdate>20071001</creationdate><title>Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis</title><author>Thomas, Claire ; Bishop, David ; Moore-Morris, Tom ; Mercier, Jacques</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-68415dcbaff457930c23a0a2e9fdde1f5cfaf9064195d34eeeea89f0513070bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alkalosis - chemically induced</topic><topic>Alkalosis - metabolism</topic><topic>Animals</topic><topic>Chronic Disease</topic><topic>Citrate (si)-Synthase - metabolism</topic><topic>Gene expression</topic><topic>Kinases</topic><topic>Lactic Acid - metabolism</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Metabolism</topic><topic>Monocarboxylic Acid Transporters - metabolism</topic><topic>Muscle Proteins - metabolism</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Musculoskeletal system</topic><topic>Phosphofructokinase-1 - metabolism</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical Exertion - physiology</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sodium Bicarbonate</topic><topic>Sodium-Bicarbonate Symporters - metabolism</topic><topic>Studies</topic><topic>Symporters - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thomas, Claire</creatorcontrib><creatorcontrib>Bishop, David</creatorcontrib><creatorcontrib>Moore-Morris, Tom</creatorcontrib><creatorcontrib>Mercier, Jacques</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thomas, Claire</au><au>Bishop, David</au><au>Moore-Morris, Tom</au><au>Mercier, Jacques</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol Endocrinol Metab</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>293</volume><issue>4</issue><spage>E916</spage><epage>E922</epage><pages>E916-E922</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><coden>AJPMD9</coden><abstract>1 Université Montpellier 1, UFR Médecine EA701, F-34295, Montpellier; 2 Institut National de la Santé et de la Recherche, ERI 25, F-34295, Montpellier; 3 Université Evry Val d'Essonne, UFR Sciences fondamentales et appliquées, EA3872, Département Sciences et Techniques des Activités Physiques et Sportives, F-91025, Evry, France; and 4 Facoltà di Scienze Motorie, Università degli Studi di Verona, Verona, Italy
Submitted 13 March 2007
; accepted in final form 28 June 2007
This study investigated the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles. Male Wistar rats performed high-intensity training on a treadmill 5 times/wk for 5 wk, receiving either sodium bicarbonate (ALK-T) or a placebo (PLA-T) prior to each training session, and were compared with a group of control rats (CON). MCT1, MCT4, and NBC content was measured by Western blotting in soleus and extensor digitorum longus (EDL) skeletal muscles. Citrate synthase (CS) and phosphofructokinase (PFK) activities and muscle buffer capacity ( m) were also evaluated. Following training, CS and PFK activities were significantly higher in the soleus only ( P < 0.05), whereas m was significantly higher in both soleus and EDL ( P < 0.05). MCT1 (PLA-T: 30%; ALK-T: 23%) and NBC contents (PLA-T: 85%; ALK-T: 60%) increased significantly only in the soleus following training ( P < 0.01). MCT4 content in the soleus was significantly greater in ALK-T (115%) but not PLA-T compared with CON. There was no significant change in protein content in the EDL. Finally, NBC content was related only to MCT1 content in soleus ( r = 0.50, P < 0.01). In conclusion, these results suggest that MCT1, MCT4, and NBC undergo fiber-specific adaptive changes in response to high-intensity training and that induced alkalosis has a positive effect on training-induced changes in MCT4 content. The correlation between MCT1 and NBC expression suggests that lactate transport may be facilitated by NBC in oxidative skeletal muscle, which may in turn favor better muscle pH regulation.
monocarboxylate transporter; sodium bicarbonate transporter; lactate transporter; muscle pH regulation; exercise
Address for reprint requests and other correspondence: C. Thomas, Université d'Evry Val d'Essonne, Département STAPS, UFR des Sciences fondamentales et appliquées, Laboratoire d'Etude de la Physiologie de l'Exercice (EA 3872), Bvd François Mitterrand, 91025 Evry Cedex, France (e-mail: thomasclaire{at}wanadoo.fr )</abstract><cop>United States</cop><pub>American Physiological Society</pub><pmid>17609257</pmid><doi>10.1152/ajpendo.00164.2007</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7583-1069</orcidid><orcidid>https://orcid.org/0000-0002-4611-042X</orcidid><orcidid>https://orcid.org/0000-0002-5037-2430</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0193-1849 |
| ispartof | American journal of physiology: endocrinology and metabolism, 2007-10, Vol.293 (4), p.E916-E922 |
| issn | 0193-1849 1522-1555 |
| language | eng |
| recordid | cdi_proquest_journals_232315358 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alkalosis - chemically induced Alkalosis - metabolism Animals Chronic Disease Citrate (si)-Synthase - metabolism Gene expression Kinases Lactic Acid - metabolism Life Sciences Male Metabolism Monocarboxylic Acid Transporters - metabolism Muscle Proteins - metabolism Muscle, Skeletal - metabolism Musculoskeletal system Phosphofructokinase-1 - metabolism Physical Conditioning, Animal - physiology Physical Exertion - physiology Proteins Rats Rats, Wistar Rodents Sodium Bicarbonate Sodium-Bicarbonate Symporters - metabolism Studies Symporters - metabolism |
| title | Effects of high-intensity training on MCT1, MCT4, and NBC expressions in rat skeletal muscles: influence of chronic metabolic alkalosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-19T22%3A04%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_highw&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20high-intensity%20training%20on%20MCT1,%20MCT4,%20and%20NBC%20expressions%20in%20rat%20skeletal%20muscles:%20influence%20of%20chronic%20metabolic%20alkalosis&rft.jtitle=American%20journal%20of%20physiology:%20endocrinology%20and%20metabolism&rft.au=Thomas,%20Claire&rft.date=2007-10-01&rft.volume=293&rft.issue=4&rft.spage=E916&rft.epage=E922&rft.pages=E916-E922&rft.issn=0193-1849&rft.eissn=1522-1555&rft.coden=AJPMD9&rft_id=info:doi/10.1152/ajpendo.00164.2007&rft_dat=%3Cproquest_highw%3E1361789471%3C/proquest_highw%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=232315358&rft_id=info:pmid/17609257&rfr_iscdi=true |