Synthesis and evaluation of pyrazole‐incorporated monocarbonyl curcumin analogues as antiproliferative and antioxidant agents

A series of pyrazole‐incorporated monocarbonyl analogues of curcumin were synthesized via Clasien–Schimidt‐type condensation and subsequently screened for in vitro antiproliferative and antioxidant activity. The analogues 4c, 5d, 5e, 5g, 6e, and 6f showed potential activity against the MDA‐MB‐231 ce...

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Veröffentlicht in:	Journal of the Chinese Chemical Society (Taipei) 2019-12, Vol.66 (12), p.1658-1665
Hauptverfasser:	Nagargoje, Amol A., Akolkar, Satish V., Siddiqui, Madiha M., Bagade, Aditi V., Kodam, Kisan M., Sangshetti, Jaiprakash N., Damale, Manoj G., Shingate, Bapurao B.
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant activity Antioxidants Antiproliferative activity Antiproliferatives Ascorbic acid Molecular docking Monocarbonyl curcumin analogues Pyrazole Scavenging Synthesis
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