IR780-polymer conjugates for stable near-infrared labeling of biodegradable polyester-based nanocarriers

[Display omitted] •The NIR probe IR780 was derivatized and covalently linked to polylactide.•The polymer-dye conjugate provides stable fluorescence labelling of nanocarriers.•Encapsulated IR780 leaks from the nanocarriers but not the polymer conjugate.•IR780 linked to PLA can be used for in vitro an...

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Veröffentlicht in:	European polymer journal 2019-11, Vol.120, p.109255, Article 109255
Hauptverfasser:	de Oliveira, Maria Alice, Guimarães Carvalho Machado, Marina, Dias Silva, Sabrina Emanuelle, Leite Nascimento, Thais, Martins Lima, Eliana, Pound-Lana, Gwenaelle, Mosqueira, Vanessa Carla Furtado
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Biodegradability Biodegradable materials Click chemistry Conjugates Conjugation Cycloaddition Drug delivery systems Dyes Entrapment Field flow fractionation Fluorescence Fluorescent dyes Fluorescent label Fractionation High performance liquid chromatography In vivo methods and tests Labeling Light scattering Nanoparticles Near infrared radiation Near-infrared probe Organic chemistry Photodynamic therapy Polylactide Polymeric nanocarrier Polymers Proteins Ring opening polymerization Serum proteins Studies
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