Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E

Changes in activity or expression of protein kinase C, reactive oxygen products, and nitric oxide may account for the alteration in cell behavior seen in diabetes. Ganz and Seftel sought to ascertain if corpus cavernosal vascular smooth muscle cells grown in a high glucose milieu exhibit changes in the activity and expression of PKC isoforms, NO, and reactive oxygen products to find out if these changes are prevented by alpha-tocopherol.