Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs
ABSTRACT In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N‐vinylcaprolactam) (PNVCL) and its blends with poly(ε‐caprolactone) and poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone). The process parameters to obtain smooth and beadless PNVCL...
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| Veröffentlicht in: | Journal of applied polymer science 2020-03, Vol.137 (11), p.n/a |
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| container_title | Journal of applied polymer science |
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| creator | Sta, Marwa Aguiar, Graziele Forni, Abilio A. J. Medeiros, Simone F. Santos, Amilton M. Demarquette, Nicole R. |
| description | ABSTRACT
In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N‐vinylcaprolactam) (PNVCL) and its blends with poly(ε‐caprolactone) and poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model‐dependent approaches. The low values of the release exponent (n |
| doi_str_mv | 10.1002/app.48472 |
| format | Article |
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In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N‐vinylcaprolactam) (PNVCL) and its blends with poly(ε‐caprolactone) and poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model‐dependent approaches. The low values of the release exponent (n < 0.5) obtained for 20 and 42 °C, indicating a Fickian diffusion mechanism for all formulations. Dissolution efficiencies (DEs) revealed the effect of polymer composition, methodology used in the electrospinning process, and temperature on the release rate of ketoprofen. PNVCL/poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone)‐based nanofibers showed greater ability to control the in vitro release of ketoprofen, in view of reduced kinetic constant and DE, making this material promising system for controlling release of hydrophobic drugs. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48472.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.48472</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Composition effects ; Contact angle ; Diameters ; Drug delivery systems ; Electrospinning ; Evaluation ; fibers ; Hydrophobicity ; Ketoprofen ; Materials science ; Nanofibers ; Polymer blends ; Polymers ; Process parameters ; Scaffolds ; Stability ; stimuli‐sensitive polymers</subject><ispartof>Journal of applied polymer science, 2020-03, Vol.137 (11), p.n/a</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3342-c0fb57d50c0b3cd0f29510843ace09ba2c70036afee27eaa47c336b7d1053a173</citedby><cites>FETCH-LOGICAL-c3342-c0fb57d50c0b3cd0f29510843ace09ba2c70036afee27eaa47c336b7d1053a173</cites><orcidid>0000-0001-7971-7458</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.48472$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.48472$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids></links><search><creatorcontrib>Sta, Marwa</creatorcontrib><creatorcontrib>Aguiar, Graziele</creatorcontrib><creatorcontrib>Forni, Abilio A. J.</creatorcontrib><creatorcontrib>Medeiros, Simone F.</creatorcontrib><creatorcontrib>Santos, Amilton M.</creatorcontrib><creatorcontrib>Demarquette, Nicole R.</creatorcontrib><title>Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs</title><title>Journal of applied polymer science</title><description>ABSTRACT
In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N‐vinylcaprolactam) (PNVCL) and its blends with poly(ε‐caprolactone) and poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model‐dependent approaches. The low values of the release exponent (n < 0.5) obtained for 20 and 42 °C, indicating a Fickian diffusion mechanism for all formulations. Dissolution efficiencies (DEs) revealed the effect of polymer composition, methodology used in the electrospinning process, and temperature on the release rate of ketoprofen. PNVCL/poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone)‐based nanofibers showed greater ability to control the in vitro release of ketoprofen, in view of reduced kinetic constant and DE, making this material promising system for controlling release of hydrophobic drugs. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48472.</description><subject>Composition effects</subject><subject>Contact angle</subject><subject>Diameters</subject><subject>Drug delivery systems</subject><subject>Electrospinning</subject><subject>Evaluation</subject><subject>fibers</subject><subject>Hydrophobicity</subject><subject>Ketoprofen</subject><subject>Materials science</subject><subject>Nanofibers</subject><subject>Polymer blends</subject><subject>Polymers</subject><subject>Process parameters</subject><subject>Scaffolds</subject><subject>Stability</subject><subject>stimuli‐sensitive polymers</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kT1uGzEQhQnDBiL_FLkBgVQuVh5y_0tDSewAQqLCdruYJYcWjfVyQ-7KUKocIWfI0XKSUJLhztUU73tvZvAY-yhgLgDkFQ7DPKuyUh6xmYC6TLJCVsdsFjWRVHWdf2CnITwBCJFDMWN_P1Owjz3HXnO1Ro9qJG9_4Whdz53hq-8Pi-W_339aDKR5j70ztiUf9gbaYDe9oeOarOeDG6kfLXY8ntJZtZcjHnhQaIzrdODGeR4mb1AR13565Jo6uyG_3cWst9q7Ye1aq_ZiOGcnBrtAF6_zjN1__XK3uE2WP26-La6XiUrTTCYKTJuXOgcFbao0GFnnAqosjVugblGqEiAt0BDJkhCzMvqKttQC8hRFmZ6xT4fcwbufE4WxeXKT7-PKRqZSFjKG7ajLA6W8C8GTaQZvn9FvGwHNroIm_t3sK4js1YF9sR1t3web69Xq4PgPn0SMrg</recordid><startdate>20200315</startdate><enddate>20200315</enddate><creator>Sta, Marwa</creator><creator>Aguiar, Graziele</creator><creator>Forni, Abilio A. J.</creator><creator>Medeiros, Simone F.</creator><creator>Santos, Amilton M.</creator><creator>Demarquette, Nicole R.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0001-7971-7458</orcidid></search><sort><creationdate>20200315</creationdate><title>Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs</title><author>Sta, Marwa ; Aguiar, Graziele ; Forni, Abilio A. J. ; Medeiros, Simone F. ; Santos, Amilton M. ; Demarquette, Nicole R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3342-c0fb57d50c0b3cd0f29510843ace09ba2c70036afee27eaa47c336b7d1053a173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Composition effects</topic><topic>Contact angle</topic><topic>Diameters</topic><topic>Drug delivery systems</topic><topic>Electrospinning</topic><topic>Evaluation</topic><topic>fibers</topic><topic>Hydrophobicity</topic><topic>Ketoprofen</topic><topic>Materials science</topic><topic>Nanofibers</topic><topic>Polymer blends</topic><topic>Polymers</topic><topic>Process parameters</topic><topic>Scaffolds</topic><topic>Stability</topic><topic>stimuli‐sensitive polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sta, Marwa</creatorcontrib><creatorcontrib>Aguiar, Graziele</creatorcontrib><creatorcontrib>Forni, Abilio A. J.</creatorcontrib><creatorcontrib>Medeiros, Simone F.</creatorcontrib><creatorcontrib>Santos, Amilton M.</creatorcontrib><creatorcontrib>Demarquette, Nicole R.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sta, Marwa</au><au>Aguiar, Graziele</au><au>Forni, Abilio A. J.</au><au>Medeiros, Simone F.</au><au>Santos, Amilton M.</au><au>Demarquette, Nicole R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs</atitle><jtitle>Journal of applied polymer science</jtitle><date>2020-03-15</date><risdate>2020</risdate><volume>137</volume><issue>11</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>ABSTRACT
In this work, nanofiber scaffolds for surface drug delivery applications were obtained by electrospinning poly(N‐vinylcaprolactam) (PNVCL) and its blends with poly(ε‐caprolactone) and poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone). The process parameters to obtain smooth and beadless PNVCL fibers were optimized. The average fibers diameter was less than 1 μm, and it was determined by scanning electron microscopy analyses. Their affinity toward water was evaluated by measuring the contact angle with water. The ketoprofen release behavior from the fibers was analyzed using independent and model‐dependent approaches. The low values of the release exponent (n < 0.5) obtained for 20 and 42 °C, indicating a Fickian diffusion mechanism for all formulations. Dissolution efficiencies (DEs) revealed the effect of polymer composition, methodology used in the electrospinning process, and temperature on the release rate of ketoprofen. PNVCL/poly(N‐vinylcaprolactam)‐b‐poly(ε‐caprolactone)‐based nanofibers showed greater ability to control the in vitro release of ketoprofen, in view of reduced kinetic constant and DE, making this material promising system for controlling release of hydrophobic drugs. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48472.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/app.48472</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0001-7971-7458</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Composition effects Contact angle Diameters Drug delivery systems Electrospinning Evaluation fibers Hydrophobicity Ketoprofen Materials science Nanofibers Polymer blends Polymers Process parameters Scaffolds Stability stimuli‐sensitive polymers |
| title | Design and characterization of PNVCL‐based nanofibers and evaluation of their potential applications as scaffolds for surface drug delivery of hydrophobic drugs |
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