Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin

The present work describes the development of poly(lactic co-glycolic acid) (PLGA) nanoparticles (NPs) of rutin (RT) for the treatment of hepatocellular carcinoma in rats. RT-loaded PLGA NPs (RT-PLGA-NPs) were prepared by double emulsion evaporation method. Further these are optimized by Box-Behnken...

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Veröffentlicht in:	Nanomedicine (London, England) England), 2018-04, Vol.13 (8), p.849-870
Hauptverfasser:	Pandey, Preeti, Rahman, Mahfoozur, Bhatt, Prakash Chandra, Beg, Sarwar, Paul, Basudev, Hafeez, Abdul, Al-Abbasi, Fahad A, Nadeem, Muhammad Shahid, Baothman, Othman, Anwar, Firoz, Kumar, Vikas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alzheimer's disease Animals antioxidant enzymes Antioxidants Antioxidants - administration & dosage Antioxidants - chemistry Bioavailability Biodegradation biomarkers Cancer therapies Carcinogens Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology diethylnitrosamine Drug Carriers Drug Liberation Drugs Emulsions - administration & dosage Emulsions - chemistry Enzymes experimental designs Food Hepatitis hepatocellular carcinoma Hepatology Homogenization Humans Inflammation Liver - drug effects Liver - pathology Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - pathology nanomedicines Nanoparticles Nanoparticles - administration & dosage Nanoparticles - chemistry Optimization Oxidative Stress - drug effects Particle Size Polylactic Acid-Polyglycolic Acid Copolymer - administration & dosage Polylactic Acid-Polyglycolic Acid Copolymer - chemistry polymeric nanoparticles Polyvinyl alcohol proinflammatory cytokines Rats Researchers rutin Rutin - administration & dosage Rutin - chemistry Rutin - pharmacology Studies Tumor necrosis factor-TNF
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