Cationic liposomes induce cell necrosis through lysosomal dysfunction and late-stage autophagic flux inhibition

The application of cationic liposomes (CLs) as nonviral vectors is hampered by their cellular toxicity. Thus we aim to investigate the mechanisms underlying the cellular toxicity of CLs. The effect of CLs on the autophagic flux, autophagosome-lysosome fusion, lysosome membrane permeabilization and c...

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Veröffentlicht in:	Nanomedicine (London, England) England), 2016-12, Vol.12 (23), p.3117-3137
Hauptverfasser:	Yang, Kaixuan, Lu, Ying, Xie, Fangyuan, Zou, Hao, Fan, Xiaoyu, Li, Bohua, Li, Wei, Zhang, Wei, Mei, Lin, Feng, Si-shen, Yin, You, Liu, Yan, Zhang, Hai, Yin, Chuan, Zhong, Yanqiang, Gao, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autophagic flux Autophagy Autophagy - drug effects Autophagy - physiology Biomedical materials Cancer therapies Cathepsin B - metabolism cationic liposomes Cations Cell Line, Tumor cellular toxicity Drug Delivery Systems - adverse effects Drug Liberation Experiments Flow cytometry gene therapy Genetic Therapy Humans Liposomes - chemistry Liposomes - toxicity lysosome membrane permeabilization Lysosomes - drug effects Lysosomes - physiology Mice Mitochondria - drug effects Mitochondria - physiology Mitochondrial DNA Nanoparticles Necrosis Necrosis - chemically induced Permeability Phosphatase Physiology Proteins Reactive Oxygen Species - metabolism Stress response Variance analysis
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