Anticancer effect of Limonin against benzo(a)pyrene‐induced lung carcinogenesis in Swiss albino mice and the inhibition of A549 cell proliferation through apoptotic pathway

The main purpose of the current study is to reveal the anticancer action of limonin against benzo(a)pyrene [B(a)P]‐treated lung carcinogenesis in Swiss albino mice and A549 lung cancer cells. B(a)P was orally supplemented (50 mg/kg body weight) twice a week for four weeks induction of lung cancer in...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2019-12, Vol.33 (12), p.e22374-n/a
Hauptverfasser:	Gong, Cuike, Qi, Lei, Huo, Yanxia, Zhang, Shiran, Ning, Xuecong, Bai, Linlin, Wang, Zhihua
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Albinism Animals anticancer Anticancer properties Anticarcinogenic Agents - therapeutic use Antigens Antioxidants Antioxidants - therapeutic use Antitumor activity Apoptosis Apoptosis - drug effects Aromatic compounds Benzo(a)pyrene Benzo(a)pyrene - administration & dosage Benzo(a)pyrene - pharmacology Biochemical analysis Body weight Carcinoembryonic antigen Carcinoembryonic Antigen - metabolism Carcinogenesis Carcinogenesis - chemically induced Carcinogenesis - drug effects Carcinogens Caspase Caspase 3 - metabolism Caspase 9 - metabolism Catalase Cell proliferation Cell Proliferation - drug effects Cell Survival - drug effects Cell viability Colorimetry Cytokines Cytokines - metabolism Enzymes Glutathione Glutathione reductase Humans Hydroxylase Inflammation Interleukins L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Limonin Limonins - therapeutic use Lipid peroxidation Lipid Peroxidation - drug effects Lipids Lung cancer Lung Neoplasms - pathology Lung Neoplasms - prevention & control Markers Mice Mice, Inbred C57BL Morphology Oxidative Stress - drug effects Peroxidation Proteins Pyrene Reactive oxygen species Reactive Oxygen Species - metabolism Reductases Superoxide dismutase Tumor Burden γ-Glutamyltransferase
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