Combined XRD-paramagnetic 13C NMR spectroscopy of 1,2,3-triazoles for revealing copper traces in a Huisgen click-chemistry cycloaddition. A model case

Copper-catalyzed Alkyne-Azide Cycloaddition (CuAAC) click chemistry robustness has been demonstrated over recent years to produce 1,2,3-triazoles with excellent yields at mild conditions with simple purification methods. However, the consequences of having copper paramagnetic traces in final product...

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Veröffentlicht in:	Heterocyclic Communications 2019-11, Vol.25 (1), p.98-106
Hauptverfasser:	Canseco-González, Daniel, O, José Luis Rodríguez de la, Herbert-Pucheta, José Enrique
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Alkynes Chemical equilibrium Chemical synthesis Copper Cycloaddition NMR NMR spectroscopy Nuclear magnetic resonance Organic chemistry Organic compounds Purification Structural analysis Triazoles X-ray diffraction
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