Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects
Background: Exacerbated postprandial lipemia is a risk factor for cardiovascular disease and is linked to insulin status. Limited data on the effect of dietary carbohydrate on postprandial lipoprotein accumulation are available. Objective: We tested the hypothesis that dietary carbohydrates with dif...
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| Veröffentlicht in: | The American journal of clinical nutrition 2004-10, Vol.80 (4), p.896-902 |
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| creator | Harbis, A Perdreau, S Vincent-Baudry, S Charbonnier, M Bernard, M.C Raccah, D Senft, M Lorec, A.M Defoort, C Portugal, H |
| description | Background: Exacerbated postprandial lipemia is a risk factor for cardiovascular disease and is linked to insulin status. Limited data on the effect of dietary carbohydrate on postprandial lipoprotein accumulation are available. Objective: We tested the hypothesis that dietary carbohydrates with different glucose availability alter postprandial lipoprotein metabolism differently in obese, insulin-resistant subjects. Design: After an overnight fast, 9 subjects with central obesity and insulin resistance but normal triacylglycerolemia randomly ingested 2 test meals with comparable amounts of fat (28-29 g) and digestible carbohydrate (91-94 g) but with different quantities of slowly available glucose (SAG) in cereal products (17 or 2 g SAG/100 g for biscuits and wheat flakes, respectively). Blood samples were collected before and for 6 h after meal intakes. Results: The postmeal 0-2-h areas under the curve (AUCs) for glycemia and insulinemia were significantly lower (P < 0.05) after the biscuit meal than after the flakes meal. Plasma triacylglycerol concentrations increased significantly after the flakes meal but not after the biscuit meal (1.5-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-100 concentrations in the triacylglycerol-rich lipoprotein fraction increased significantly 2 h after the flakes meal but not after the biscuit meal (3-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-48 concentrations increased (P < 0.05) 4 h after the flakes meal but not after the biscuit meal (2.3-fold higher 0-6-h AUC for the flakes meal). Conclusion: Mixed meals containing slowly digestible carbohydrate that induces low glycemic and insulinemic responses reduce the postprandial accumulation of both hepatically and intestinally derived triacylglycerol-rich lipoproteins in obese subjects with insulin resistance. |
| doi_str_mv | 10.1093/ajcn/80.4.896 |
| format | Article |
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Limited data on the effect of dietary carbohydrate on postprandial lipoprotein accumulation are available. Objective: We tested the hypothesis that dietary carbohydrates with different glucose availability alter postprandial lipoprotein metabolism differently in obese, insulin-resistant subjects. Design: After an overnight fast, 9 subjects with central obesity and insulin resistance but normal triacylglycerolemia randomly ingested 2 test meals with comparable amounts of fat (28-29 g) and digestible carbohydrate (91-94 g) but with different quantities of slowly available glucose (SAG) in cereal products (17 or 2 g SAG/100 g for biscuits and wheat flakes, respectively). Blood samples were collected before and for 6 h after meal intakes. Results: The postmeal 0-2-h areas under the curve (AUCs) for glycemia and insulinemia were significantly lower (P < 0.05) after the biscuit meal than after the flakes meal. Plasma triacylglycerol concentrations increased significantly after the flakes meal but not after the biscuit meal (1.5-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-100 concentrations in the triacylglycerol-rich lipoprotein fraction increased significantly 2 h after the flakes meal but not after the biscuit meal (3-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-48 concentrations increased (P < 0.05) 4 h after the flakes meal but not after the biscuit meal (2.3-fold higher 0-6-h AUC for the flakes meal). Conclusion: Mixed meals containing slowly digestible carbohydrate that induces low glycemic and insulinemic responses reduce the postprandial accumulation of both hepatically and intestinally derived triacylglycerol-rich lipoproteins in obese subjects with insulin resistance.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/80.4.896</identifier><identifier>PMID: 15447896</identifier><language>eng</language><publisher>United States: American Society for Clinical Nutrition, Inc</publisher><subject>Adult ; apolipoproteins ; Area Under Curve ; biosynthesis ; Blood Glucose - analysis ; Blood Glucose - metabolism ; Carbohydrates ; Cardiovascular disease ; Cross-Over Studies ; dietary carbohydrate ; Dietary Carbohydrates - administration & dosage ; Dietary Carbohydrates - classification ; Dietary Carbohydrates - pharmacokinetics ; digestion ; Digestive system ; Female ; glucose ; Glucose - administration & dosage ; Glucose - pharmacokinetics ; glycemic effect ; Glycemic Index ; Humans ; Insulin ; Insulin - analysis ; Insulin - blood ; insulin resistance ; Insulin Resistance - physiology ; Intestinal Absorption ; intestines ; Lipids ; Lipoproteins - metabolism ; Liver ; Liver - metabolism ; Male ; Middle Aged ; Nutritive Value ; Obesity ; Obesity - metabolism ; Postprandial Period ; postprandial state ; Proteins ; rapidly available glucose ; Risk factors ; slowly available glucose ; slowly digestible carbohydrate ; triacylglycerols ; Triglycerides - blood</subject><ispartof>The American journal of clinical nutrition, 2004-10, Vol.80 (4), p.896-902</ispartof><rights>Copyright American Society for Clinical Nutrition, Inc. Oct 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-854f3328ec91d87381c5d83f38ce6cac5cd077666883fca4168a1dcf3cc7ac2b3</citedby><cites>FETCH-LOGICAL-c379t-854f3328ec91d87381c5d83f38ce6cac5cd077666883fca4168a1dcf3cc7ac2b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15447896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harbis, A</creatorcontrib><creatorcontrib>Perdreau, S</creatorcontrib><creatorcontrib>Vincent-Baudry, S</creatorcontrib><creatorcontrib>Charbonnier, M</creatorcontrib><creatorcontrib>Bernard, M.C</creatorcontrib><creatorcontrib>Raccah, D</creatorcontrib><creatorcontrib>Senft, M</creatorcontrib><creatorcontrib>Lorec, A.M</creatorcontrib><creatorcontrib>Defoort, C</creatorcontrib><creatorcontrib>Portugal, H</creatorcontrib><title>Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Background: Exacerbated postprandial lipemia is a risk factor for cardiovascular disease and is linked to insulin status. Limited data on the effect of dietary carbohydrate on postprandial lipoprotein accumulation are available. Objective: We tested the hypothesis that dietary carbohydrates with different glucose availability alter postprandial lipoprotein metabolism differently in obese, insulin-resistant subjects. Design: After an overnight fast, 9 subjects with central obesity and insulin resistance but normal triacylglycerolemia randomly ingested 2 test meals with comparable amounts of fat (28-29 g) and digestible carbohydrate (91-94 g) but with different quantities of slowly available glucose (SAG) in cereal products (17 or 2 g SAG/100 g for biscuits and wheat flakes, respectively). Blood samples were collected before and for 6 h after meal intakes. Results: The postmeal 0-2-h areas under the curve (AUCs) for glycemia and insulinemia were significantly lower (P < 0.05) after the biscuit meal than after the flakes meal. Plasma triacylglycerol concentrations increased significantly after the flakes meal but not after the biscuit meal (1.5-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-100 concentrations in the triacylglycerol-rich lipoprotein fraction increased significantly 2 h after the flakes meal but not after the biscuit meal (3-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-48 concentrations increased (P < 0.05) 4 h after the flakes meal but not after the biscuit meal (2.3-fold higher 0-6-h AUC for the flakes meal). Conclusion: Mixed meals containing slowly digestible carbohydrate that induces low glycemic and insulinemic responses reduce the postprandial accumulation of both hepatically and intestinally derived triacylglycerol-rich lipoproteins in obese subjects with insulin resistance.</description><subject>Adult</subject><subject>apolipoproteins</subject><subject>Area Under Curve</subject><subject>biosynthesis</subject><subject>Blood Glucose - analysis</subject><subject>Blood Glucose - metabolism</subject><subject>Carbohydrates</subject><subject>Cardiovascular disease</subject><subject>Cross-Over Studies</subject><subject>dietary carbohydrate</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Carbohydrates - classification</subject><subject>Dietary Carbohydrates - pharmacokinetics</subject><subject>digestion</subject><subject>Digestive system</subject><subject>Female</subject><subject>glucose</subject><subject>Glucose - administration & dosage</subject><subject>Glucose - pharmacokinetics</subject><subject>glycemic effect</subject><subject>Glycemic Index</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - analysis</subject><subject>Insulin - blood</subject><subject>insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Intestinal Absorption</subject><subject>intestines</subject><subject>Lipids</subject><subject>Lipoproteins - metabolism</subject><subject>Liver</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nutritive Value</subject><subject>Obesity</subject><subject>Obesity - metabolism</subject><subject>Postprandial Period</subject><subject>postprandial state</subject><subject>Proteins</subject><subject>rapidly available glucose</subject><subject>Risk factors</subject><subject>slowly available glucose</subject><subject>slowly digestible carbohydrate</subject><subject>triacylglycerols</subject><subject>Triglycerides - blood</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1P5DAMhiMEWgZ2j1yh2jMdkiZN0yNCy4eExGGXc5RxU8ioTUqcHuZv8Is3wwxwsmw_tl-9JuSM0SWjLb8ya_BXii7FUrXygCxYy1XJK9ockgWltCpbJutjcoK4ppRVQskf5JjVQjSZX5D3u2EDdnRQGN8VzuM8OP-Rj9YMRbQ4BY8WizF082CSLaaAaYqZdrn_aieTvoaTxeR8Lg9uClMMyTpfGIB53I664DNThJVFe_l5qswXHCbjU4Hzam0h4U9y1JsB7a99PCXPt3_-3dyXj093DzfXjyXwpk2lqkXPeaUstKxTDVcM6k7xniuwEgzU0NGmkVKqXAQjmFSGddBzgMZAteKn5Pdub1b6Nmfpeh3mmOWjrni2sRWKZqjcQRADYrS9nqIbTdxoRvX2AXr7AK2oFjobmvnz_dJ5Ndrum947noGLHdCboM1LdKif_1aUcUrbmknR8P92yY_J</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Harbis, A</creator><creator>Perdreau, S</creator><creator>Vincent-Baudry, S</creator><creator>Charbonnier, M</creator><creator>Bernard, M.C</creator><creator>Raccah, D</creator><creator>Senft, M</creator><creator>Lorec, A.M</creator><creator>Defoort, C</creator><creator>Portugal, H</creator><general>American Society for Clinical Nutrition, Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope></search><sort><creationdate>20041001</creationdate><title>Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects</title><author>Harbis, A ; Perdreau, S ; Vincent-Baudry, S ; Charbonnier, M ; Bernard, M.C ; Raccah, D ; Senft, M ; Lorec, A.M ; Defoort, C ; Portugal, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-854f3328ec91d87381c5d83f38ce6cac5cd077666883fca4168a1dcf3cc7ac2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>apolipoproteins</topic><topic>Area Under Curve</topic><topic>biosynthesis</topic><topic>Blood Glucose - analysis</topic><topic>Blood Glucose - metabolism</topic><topic>Carbohydrates</topic><topic>Cardiovascular disease</topic><topic>Cross-Over Studies</topic><topic>dietary carbohydrate</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Carbohydrates - classification</topic><topic>Dietary Carbohydrates - pharmacokinetics</topic><topic>digestion</topic><topic>Digestive system</topic><topic>Female</topic><topic>glucose</topic><topic>Glucose - administration & dosage</topic><topic>Glucose - pharmacokinetics</topic><topic>glycemic effect</topic><topic>Glycemic Index</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - analysis</topic><topic>Insulin - blood</topic><topic>insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Intestinal Absorption</topic><topic>intestines</topic><topic>Lipids</topic><topic>Lipoproteins - metabolism</topic><topic>Liver</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nutritive Value</topic><topic>Obesity</topic><topic>Obesity - metabolism</topic><topic>Postprandial Period</topic><topic>postprandial state</topic><topic>Proteins</topic><topic>rapidly available glucose</topic><topic>Risk factors</topic><topic>slowly available glucose</topic><topic>slowly digestible carbohydrate</topic><topic>triacylglycerols</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harbis, A</creatorcontrib><creatorcontrib>Perdreau, S</creatorcontrib><creatorcontrib>Vincent-Baudry, S</creatorcontrib><creatorcontrib>Charbonnier, M</creatorcontrib><creatorcontrib>Bernard, M.C</creatorcontrib><creatorcontrib>Raccah, D</creatorcontrib><creatorcontrib>Senft, M</creatorcontrib><creatorcontrib>Lorec, A.M</creatorcontrib><creatorcontrib>Defoort, C</creatorcontrib><creatorcontrib>Portugal, H</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harbis, A</au><au>Perdreau, S</au><au>Vincent-Baudry, S</au><au>Charbonnier, M</au><au>Bernard, M.C</au><au>Raccah, D</au><au>Senft, M</au><au>Lorec, A.M</au><au>Defoort, C</au><au>Portugal, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>80</volume><issue>4</issue><spage>896</spage><epage>902</epage><pages>896-902</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><abstract>Background: Exacerbated postprandial lipemia is a risk factor for cardiovascular disease and is linked to insulin status. Limited data on the effect of dietary carbohydrate on postprandial lipoprotein accumulation are available. Objective: We tested the hypothesis that dietary carbohydrates with different glucose availability alter postprandial lipoprotein metabolism differently in obese, insulin-resistant subjects. Design: After an overnight fast, 9 subjects with central obesity and insulin resistance but normal triacylglycerolemia randomly ingested 2 test meals with comparable amounts of fat (28-29 g) and digestible carbohydrate (91-94 g) but with different quantities of slowly available glucose (SAG) in cereal products (17 or 2 g SAG/100 g for biscuits and wheat flakes, respectively). Blood samples were collected before and for 6 h after meal intakes. Results: The postmeal 0-2-h areas under the curve (AUCs) for glycemia and insulinemia were significantly lower (P < 0.05) after the biscuit meal than after the flakes meal. Plasma triacylglycerol concentrations increased significantly after the flakes meal but not after the biscuit meal (1.5-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-100 concentrations in the triacylglycerol-rich lipoprotein fraction increased significantly 2 h after the flakes meal but not after the biscuit meal (3-fold higher 0-6-h AUC for the flakes meal). Apolipoprotein B-48 concentrations increased (P < 0.05) 4 h after the flakes meal but not after the biscuit meal (2.3-fold higher 0-6-h AUC for the flakes meal). Conclusion: Mixed meals containing slowly digestible carbohydrate that induces low glycemic and insulinemic responses reduce the postprandial accumulation of both hepatically and intestinally derived triacylglycerol-rich lipoproteins in obese subjects with insulin resistance.</abstract><cop>United States</cop><pub>American Society for Clinical Nutrition, Inc</pub><pmid>15447896</pmid><doi>10.1093/ajcn/80.4.896</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult apolipoproteins Area Under Curve biosynthesis Blood Glucose - analysis Blood Glucose - metabolism Carbohydrates Cardiovascular disease Cross-Over Studies dietary carbohydrate Dietary Carbohydrates - administration & dosage Dietary Carbohydrates - classification Dietary Carbohydrates - pharmacokinetics digestion Digestive system Female glucose Glucose - administration & dosage Glucose - pharmacokinetics glycemic effect Glycemic Index Humans Insulin Insulin - analysis Insulin - blood insulin resistance Insulin Resistance - physiology Intestinal Absorption intestines Lipids Lipoproteins - metabolism Liver Liver - metabolism Male Middle Aged Nutritive Value Obesity Obesity - metabolism Postprandial Period postprandial state Proteins rapidly available glucose Risk factors slowly available glucose slowly digestible carbohydrate triacylglycerols Triglycerides - blood |
| title | Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein accumulation in obese, insulin-resistant subjects |
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