Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole

Subjects taking a hydrogen pump blocking agent (omeprazole) develop bacterial overgrowth of the small intestine. We tested the hypothesis that this bacterial overgrowth produces menaquinones, which would meet the vitamin requirement in situations of vitamin K deficiency. In a crossover-type design,...

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Veröffentlicht in:	The American journal of clinical nutrition 1998-09, Vol.68 (3), p.699-704
Hauptverfasser:	PAIVA, S. A. R, SEPE, T. E, BOOTH, S. L, CAMILO, M. E, O'BRIEN, M. E, DAVIDSON, K. W, SADOWSKI, J. A, RUSSELL, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Carboxyglutamic Acid - urine Achlorhydria - chemically induced Achlorhydria - metabolism Achlorhydria - microbiology Adult Aged Bacteria Bacteria - growth & development Biological and medical sciences Biomarkers Cross-Over Studies Diet Drug Interactions Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans Intestine, Small - drug effects Intestine, Small - metabolism Intestine, Small - microbiology Middle Aged Nutrition Omeprazole - administration & dosage Omeprazole - pharmacology Osteocalcin - blood Pharmaceuticals Protein Precursors - metabolism Prothrombin - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin K - biosynthesis Vitamin K 1 - administration & dosage Vitamin K 1 - blood Vitamin K 1 - pharmacology Vitamin K Deficiency - drug therapy Vitamin K Deficiency - metabolism Vitamins
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