Dosage sensitivity intolerance of VIPR2 microduplication is disease causative to manifest schizophrenia-like phenotypes in a novel BAC transgenic mouse model

Recent genome-wide association studies (GWAS) have identified copy number variations (CNVs) at chromosomal locus 7q36.3 that significantly contribute to the risk of schizophrenia, with all of the microduplications occurring within a single gene: vasoactive intestinal peptide receptor 2 (VIPR2). To c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular psychiatry 2019-12, Vol.24 (12), p.1884-1901
Hauptverfasser:	Tian, Xinli, Richard, Adam, El-Saadi, Madison Wynne, Bhandari, Aakriti, Latimer, Brian, Van Savage, Isabella, Holmes, Kevlyn, Klein, Ronald L., Dwyer, Donard, Goeders, Nicholas E., Yang, X. William, Lu, Xiao-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	13 14 14/19 38 42/41 42/44 59/5 631/208 64 64/110 692/699/476/1799 82/51 96 Animal models Artificial chromosomes Bacterial artificial chromosomes Behavioral Sciences Biological Psychology Channel gating Chromosome 7 Cognition disorders Cognitive ability Copy number Dopamine Dopamine D2 receptors Etiology Gene expression Genes Genetic aspects Genetic engineering Genome-wide association studies Genomes Genomics Intestine Intolerance Medicine Medicine & Public Health Mental disorders Mice Neostriatum Neural circuitry Neural networks Neurons Neurosciences Pharmacotherapy Phenotypes Protein kinase A Psychiatry Rodents Schizophrenia Sensorimotor gating Structure-function relationships Transgenic mice Vasoactive agents Vasoactive intestinal peptide Vasoactive intestinal peptides
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!