Synthesis of substituted N-phenylmaleimides and use in a Diels-Alder reaction: a green multi-step synthesis for an undergraduate organic chemistry laboratory

This paper describes the design and implementation of a minimally hazardous, environmentally friendly, and energy efficient sequential reaction sequence within a sophomore level Organic Chemistry lab course to efficiently synthesize N-phenylmaleimide precursors for a Diels-Alder reaction. Substitute...

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Veröffentlicht in:	Green chemistry letters and reviews 2019-04, Vol.12 (2), p.127-135
Hauptverfasser:	Bastin, Loyd D., Nigam, Manisha, Martinus, Sam, Maloney, James E., Benyack, Landon L., Gainer, Brendan
Format:	Artikel
Sprache:	eng
Schlagworte:	Accident prevention amine acylation Aniline Atom economy Biological properties Chemical synthesis Diels-Alder Energy efficiency Forensic engineering Green chemistry Intermediates Magnetic resonance spectroscopy Maleic anhydride maleimide multi-step synthesis NMR NMR spectroscopy Nuclear magnetic resonance Organic chemistry Precursors Students Substitutes Undergraduate organic chemistry
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