Improving 1-year outcome in first-episode psychosis: OPUS trial
Because early illness course and outcome may affect the long-term outcome of schizophrenia-spectrum disorders, it is especially important to address poor outcome in this early critical period. To evaluate whether integrated treatment compared with standard treatment reduced the proportion of patient...
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| Veröffentlicht in: | British journal of psychiatry 2005-08, Vol.187 (48), p.s98-s103 |
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| container_end_page | s103 |
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| container_issue | 48 |
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| container_title | British journal of psychiatry |
| container_volume | 187 |
| creator | PETERSEN, LONE NORDENTOFT, MERETE JEPPESEN, PIA OHLENSCHLAeGER, JOHAN THORUP, ANNE CHRISTENSEN, TORBEN OSTERGAARD KRARUP, GERTRUD DAHLSTROM, JYTTE HAASTRUP, BODIL JORGENSEN, PER |
| description | Because early illness course and outcome may affect the long-term outcome of schizophrenia-spectrum disorders, it is especially important to address poor outcome in this early critical period.
To evaluate whether integrated treatment compared with standard treatment reduced the proportion of patients with poor clinical and social outcome after 1 year.
A total of 547 patients with first-episode psychosis were included in the study, 275 randomly assigned to integrated treatment and 272 to standard treatment. Measures assessed psychotic symptoms and social functioning.
There was a significant beneficial effect of integrated treatment v. standard treatment on "any poor outcome". Integrated treatment had a significantly better effect on "any poor outcome" in patients with schizophrenia compared with patients in standard treatment.
The integrated treatment significantly reduced the proportion of patients with poor clinical and social outcome compared with standard treatment. |
| doi_str_mv | 10.1192/bjp.187.48.s98 |
| format | Article |
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To evaluate whether integrated treatment compared with standard treatment reduced the proportion of patients with poor clinical and social outcome after 1 year.
A total of 547 patients with first-episode psychosis were included in the study, 275 randomly assigned to integrated treatment and 272 to standard treatment. Measures assessed psychotic symptoms and social functioning.
There was a significant beneficial effect of integrated treatment v. standard treatment on "any poor outcome". Integrated treatment had a significantly better effect on "any poor outcome" in patients with schizophrenia compared with patients in standard treatment.
The integrated treatment significantly reduced the proportion of patients with poor clinical and social outcome compared with standard treatment.</description><identifier>ISSN: 0007-1250</identifier><identifier>ISSN: 0960-5371</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.187.48.s98</identifier><identifier>PMID: 16055817</identifier><language>eng</language><publisher>England: RCP</publisher><subject>Adolescent ; Adult ; Bias ; Critical period ; Delivery of Health Care, Integrated - standards ; Female ; Humans ; Illnesses ; Intervention ; Interviews ; Long term ; Male ; Mental disorders ; Middle Aged ; Outcome Assessment (Health Care) ; Patients ; Psychiatry ; Psychosis ; Psychotic Disorders - therapy ; Psychotic symptoms ; Psychotropic drugs ; Schizophrenia ; Social Adjustment ; Social functioning ; Social skills ; Treatment Failure</subject><ispartof>British journal of psychiatry, 2005-08, Vol.187 (48), p.s98-s103</ispartof><rights>Copyright © 2005 The Royal College of Psychiatrists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c303t-b3313f12219bb74f96e33e031c2071d57169ac003792188aa8e34a12811e369a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,12851,27929,27930,31004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16055817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PETERSEN, LONE</creatorcontrib><creatorcontrib>NORDENTOFT, MERETE</creatorcontrib><creatorcontrib>JEPPESEN, PIA</creatorcontrib><creatorcontrib>OHLENSCHLAeGER, JOHAN</creatorcontrib><creatorcontrib>THORUP, ANNE</creatorcontrib><creatorcontrib>CHRISTENSEN, TORBEN OSTERGAARD</creatorcontrib><creatorcontrib>KRARUP, GERTRUD</creatorcontrib><creatorcontrib>DAHLSTROM, JYTTE</creatorcontrib><creatorcontrib>HAASTRUP, BODIL</creatorcontrib><creatorcontrib>JORGENSEN, PER</creatorcontrib><title>Improving 1-year outcome in first-episode psychosis: OPUS trial</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry Suppl</addtitle><description>Because early illness course and outcome may affect the long-term outcome of schizophrenia-spectrum disorders, it is especially important to address poor outcome in this early critical period.
To evaluate whether integrated treatment compared with standard treatment reduced the proportion of patients with poor clinical and social outcome after 1 year.
A total of 547 patients with first-episode psychosis were included in the study, 275 randomly assigned to integrated treatment and 272 to standard treatment. Measures assessed psychotic symptoms and social functioning.
There was a significant beneficial effect of integrated treatment v. standard treatment on "any poor outcome". Integrated treatment had a significantly better effect on "any poor outcome" in patients with schizophrenia compared with patients in standard treatment.
The integrated treatment significantly reduced the proportion of patients with poor clinical and social outcome compared with standard treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bias</subject><subject>Critical period</subject><subject>Delivery of Health Care, Integrated - standards</subject><subject>Female</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Intervention</subject><subject>Interviews</subject><subject>Long term</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Outcome Assessment (Health Care)</subject><subject>Patients</subject><subject>Psychiatry</subject><subject>Psychosis</subject><subject>Psychotic Disorders - therapy</subject><subject>Psychotic symptoms</subject><subject>Psychotropic drugs</subject><subject>Schizophrenia</subject><subject>Social Adjustment</subject><subject>Social functioning</subject><subject>Social skills</subject><subject>Treatment Failure</subject><issn>0007-1250</issn><issn>0960-5371</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkF1LwzAUhoMobk5vvZSi4F1rTj6a1BuR4cdgMEF3HdIu3TLatSatsn9vdAPFq8PhPOfl5UHoHHACkJGbfN0mIEXCZOIzeYCGwASJgaX8EA0xxiIGwvEAnXi_DitlRByjAaSYcwliiO4mdeuaD7tZRhBvjXZR03dFU5vIbqLSOt_FprW-WZio9dti1Xjrb6PZy_w16pzV1Sk6KnXlzdl-jtD88eFt_BxPZ0-T8f00LiimXZxTCrQEQiDLc8HKLDWUGkyhIFjAggtIM12EfiIjIKXW0lCmgUgAQ8OJjtD1Lje0fe-N71RtfWGqSm9M03uVSkYx4xDAq3_guundJnRThAJPQVKeBirZUYVrvHemVK2ztXZbBVh9i1VBrApiFZMqiA0PF_vYPq_N4hffmwzA5Q5Y2eXq0zqjXPFj7G_KF9_dfRc</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>PETERSEN, LONE</creator><creator>NORDENTOFT, MERETE</creator><creator>JEPPESEN, PIA</creator><creator>OHLENSCHLAeGER, JOHAN</creator><creator>THORUP, ANNE</creator><creator>CHRISTENSEN, TORBEN OSTERGAARD</creator><creator>KRARUP, GERTRUD</creator><creator>DAHLSTROM, JYTTE</creator><creator>HAASTRUP, BODIL</creator><creator>JORGENSEN, PER</creator><general>RCP</general><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Improving 1-year outcome in first-episode psychosis: OPUS trial</title><author>PETERSEN, LONE ; 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To evaluate whether integrated treatment compared with standard treatment reduced the proportion of patients with poor clinical and social outcome after 1 year.
A total of 547 patients with first-episode psychosis were included in the study, 275 randomly assigned to integrated treatment and 272 to standard treatment. Measures assessed psychotic symptoms and social functioning.
There was a significant beneficial effect of integrated treatment v. standard treatment on "any poor outcome". Integrated treatment had a significantly better effect on "any poor outcome" in patients with schizophrenia compared with patients in standard treatment.
The integrated treatment significantly reduced the proportion of patients with poor clinical and social outcome compared with standard treatment.</abstract><cop>England</cop><pub>RCP</pub><pmid>16055817</pmid><doi>10.1192/bjp.187.48.s98</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1250 |
| ispartof | British journal of psychiatry, 2005-08, Vol.187 (48), p.s98-s103 |
| issn | 0007-1250 0960-5371 1472-1465 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Cambridge Journals; Applied Social Sciences Index & Abstracts (ASSIA); Alma/SFX Local Collection |
| subjects | Adolescent Adult Bias Critical period Delivery of Health Care, Integrated - standards Female Humans Illnesses Intervention Interviews Long term Male Mental disorders Middle Aged Outcome Assessment (Health Care) Patients Psychiatry Psychosis Psychotic Disorders - therapy Psychotic symptoms Psychotropic drugs Schizophrenia Social Adjustment Social functioning Social skills Treatment Failure |
| title | Improving 1-year outcome in first-episode psychosis: OPUS trial |
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