Kaleidoscope
Following earlier research showing that the single-item ‘depressed mood’ component of the Hamilton Rating Scale for Depression (HRSD) was most sensitive to medication change, Hieronymus et al 4 undertook a patient-level mega-analysis of 11 randomised controlled trials, exploring dose-dependent chang...
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| Veröffentlicht in: | British journal of psychiatry 2016-09, Vol.209 (3), p.268-269 |
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| container_title | British journal of psychiatry |
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| creator | Tracy, Derek K Joyce, Dan W Shergill, Sukhwinder S |
| description | Following earlier research showing that the single-item ‘depressed mood’ component of the Hamilton Rating Scale for Depression (HRSD) was most sensitive to medication change, Hieronymus et al 4 undertook a patient-level mega-analysis of 11 randomised controlled trials, exploring dose-dependent changes to this single item (rather than the summed total HRSD). Clinical, demographic, neurocognitive and psychosocial factors were evaluated, and factors predicting conversion to a psychotic illness were high levels of unusual thought content and suspiciousness, greater decline in social functioning, lower verbal learning and memory performance, slower speed of processing and younger age at baseline. Participants with greater accuracy showed more directional modulation (i.e. the angle of the trajectory in the 2D conceptual space of neck/leg length and Christmas symbols) of the fMRI BOLD signal in the ventral aspect of the medial prefrontal cortex, with correlated activity in the entorhinal cortex suggesting multiple areas were responding with the same ‘conceptual’ trajectory preference. [...]we've all been stumped by a smart (or smarmy) student asking us to explain the phenomenological difference between a hallucination and a dream. |
| doi_str_mv | 10.1192/bjp.209.3.268 |
| format | Article |
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[...]we've all been stumped by a smart (or smarmy) student asking us to explain the phenomenological difference between a hallucination and a dream.</abstract><cop>London</cop><pub>Cambridge University Press</pub><doi>10.1192/bjp.209.3.268</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1250 |
| ispartof | British journal of psychiatry, 2016-09, Vol.209 (3), p.268-269 |
| issn | 0007-1250 1472-1465 |
| language | eng |
| recordid | cdi_proquest_journals_2315611774 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); Cambridge Journals Online; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Antidepressants Brain research Change agents Christmas Clinical trials Cognition Consciousness Conversion Cortex Cortex (entorhinal) Demography Drug dosages Drugs Entorhinal cortex Families & family life Functional magnetic resonance imaging Hallucinations Mental disorders Mental health care Mood Mutation Neck Perceptions Prefrontal cortex Psychiatry Psychosis Psychosocial factors Schizophrenia Sleep Social discrimination learning Social functioning Trust Verbal memory |
| title | Kaleidoscope |
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