Paternal age at birth and high-functioning autistic-spectrumdisorder in offspring
BackgroundPrevious studies have reported the association between advanced paternalage at birth and the risk of autistic-spectrum disorder in offspring,including offspring with intellectual disability.AimsTo test whether an association between advanced paternal age at birth isfound in offspring with...
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| Veröffentlicht in: | British journal of psychiatry 2008-10, Vol.193 (4), p.316-321 |
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| creator | Tsuchiya, Kenji J Matsumoto Kaori Miyachi Taishi Tsujii Masatsugu Nakamura, Kazuhiko Takagai Shu Kawai Masayoshi Yagi Atsuko Iwaki Kimie Suda Shiro Sugihara Genichi Iwata Yasuhide Matsuzaki Hideo Yoshimoto, Sekine Suzuki, Katsuaki Sugiyama Toshirou Mori Norio Takei Nori |
| description | BackgroundPrevious studies have reported the association between advanced paternalage at birth and the risk of autistic-spectrum disorder in offspring,including offspring with intellectual disability.AimsTo test whether an association between advanced paternal age at birth isfound in offspring with high-functioning autistic-spectrum disorder (i.e.offspring without intellectual disability).MethodA case–control study was conducted in Japan. The participants consistedof individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorderor related diagnosis. Unrelated healthy volunteers were recruited ascontrols. Parental ages were divided into tertiles (i.e. three ageclasses). Odds ratios and 95% confidence intervals were estimated usinglogistic regression analyses, with an adjustment for age, gender andbirth order.ResultsEighty-four individuals with autistic-spectrum disorder but withoutintellectual disability and 208 healthy controls were enrolled. Increasedpaternal, but not maternal, age was associated with an elevated risk ofhigh-functioning autistic-spectrum disorder. A one-level advance inpaternal age class corresponded to a 1.8-fold increase in risk, afteradjustment for covariates.ConclusionsAdvanced paternal age is associated with an increased risk forhigh-functioning autistic-spectrum disorder. |
| doi_str_mv | 10.1192/bjp.bp.107.045120 |
| format | Article |
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The participants consistedof individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorderor related diagnosis. Unrelated healthy volunteers were recruited ascontrols. Parental ages were divided into tertiles (i.e. three ageclasses). Odds ratios and 95% confidence intervals were estimated usinglogistic regression analyses, with an adjustment for age, gender andbirth order.ResultsEighty-four individuals with autistic-spectrum disorder but withoutintellectual disability and 208 healthy controls were enrolled. Increasedpaternal, but not maternal, age was associated with an elevated risk ofhigh-functioning autistic-spectrum disorder. A one-level advance inpaternal age class corresponded to a 1.8-fold increase in risk, afteradjustment for covariates.ConclusionsAdvanced paternal age is associated with an increased risk forhigh-functioning autistic-spectrum disorder.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.bp.107.045120</identifier><language>eng ; jpn</language><publisher>London: Cambridge University Press</publisher><subject>Age ; Autism ; Birth ; Birth order ; Childbirth & labor ; Children & youth ; Childrens health ; Epilepsy ; Families & family life ; Gender roles ; Genotype & phenotype ; Handbooks ; Health risk assessment ; High functioning ; Intellectual disabilities ; Intelligence ; Intelligence tests ; Males ; Medical diagnosis ; Mental disorders ; Mutation ; Offspring ; Parents & parenting ; Psychiatry ; Risk ; Schizophrenia ; Social classes ; Socioeconomic factors ; Volunteers</subject><ispartof>British journal of psychiatry, 2008-10, Vol.193 (4), p.316-321</ispartof><rights>Copyright © Royal College of Psychiatrists, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,12846,27344,27924,27925,30999,33774</link.rule.ids></links><search><creatorcontrib>Tsuchiya, Kenji J</creatorcontrib><creatorcontrib>Matsumoto Kaori</creatorcontrib><creatorcontrib>Miyachi Taishi</creatorcontrib><creatorcontrib>Tsujii Masatsugu</creatorcontrib><creatorcontrib>Nakamura, Kazuhiko</creatorcontrib><creatorcontrib>Takagai Shu</creatorcontrib><creatorcontrib>Kawai Masayoshi</creatorcontrib><creatorcontrib>Yagi Atsuko</creatorcontrib><creatorcontrib>Iwaki Kimie</creatorcontrib><creatorcontrib>Suda Shiro</creatorcontrib><creatorcontrib>Sugihara Genichi</creatorcontrib><creatorcontrib>Iwata Yasuhide</creatorcontrib><creatorcontrib>Matsuzaki Hideo</creatorcontrib><creatorcontrib>Yoshimoto, Sekine</creatorcontrib><creatorcontrib>Suzuki, Katsuaki</creatorcontrib><creatorcontrib>Sugiyama Toshirou</creatorcontrib><creatorcontrib>Mori Norio</creatorcontrib><creatorcontrib>Takei Nori</creatorcontrib><title>Paternal age at birth and high-functioning autistic-spectrumdisorder in offspring</title><title>British journal of psychiatry</title><description>BackgroundPrevious studies have reported the association between advanced paternalage at birth and the risk of autistic-spectrum disorder in offspring,including offspring with intellectual disability.AimsTo test whether an association between advanced paternal age at birth isfound in offspring with high-functioning autistic-spectrum disorder (i.e.offspring without intellectual disability).MethodA case–control study was conducted in Japan. The participants consistedof individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorderor related diagnosis. Unrelated healthy volunteers were recruited ascontrols. Parental ages were divided into tertiles (i.e. three ageclasses). Odds ratios and 95% confidence intervals were estimated usinglogistic regression analyses, with an adjustment for age, gender andbirth order.ResultsEighty-four individuals with autistic-spectrum disorder but withoutintellectual disability and 208 healthy controls were enrolled. Increasedpaternal, but not maternal, age was associated with an elevated risk ofhigh-functioning autistic-spectrum disorder. A one-level advance inpaternal age class corresponded to a 1.8-fold increase in risk, afteradjustment for covariates.ConclusionsAdvanced paternal age is associated with an increased risk forhigh-functioning autistic-spectrum disorder.</description><subject>Age</subject><subject>Autism</subject><subject>Birth</subject><subject>Birth order</subject><subject>Childbirth & labor</subject><subject>Children & youth</subject><subject>Childrens health</subject><subject>Epilepsy</subject><subject>Families & family life</subject><subject>Gender roles</subject><subject>Genotype & phenotype</subject><subject>Handbooks</subject><subject>Health risk assessment</subject><subject>High functioning</subject><subject>Intellectual disabilities</subject><subject>Intelligence</subject><subject>Intelligence tests</subject><subject>Males</subject><subject>Medical diagnosis</subject><subject>Mental disorders</subject><subject>Mutation</subject><subject>Offspring</subject><subject>Parents & parenting</subject><subject>Psychiatry</subject><subject>Risk</subject><subject>Schizophrenia</subject><subject>Social classes</subject><subject>Socioeconomic 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; Kawai Masayoshi ; Yagi Atsuko ; Iwaki Kimie ; Suda Shiro ; Sugihara Genichi ; Iwata Yasuhide ; Matsuzaki Hideo ; Yoshimoto, Sekine ; Suzuki, Katsuaki ; Sugiyama Toshirou ; Mori Norio ; Takei Nori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j940-632da7136b569e3ea6dbf5b76cfafddf503badb8969bc0ab10b17e35bfc440703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>2008</creationdate><topic>Age</topic><topic>Autism</topic><topic>Birth</topic><topic>Birth order</topic><topic>Childbirth & labor</topic><topic>Children & youth</topic><topic>Childrens health</topic><topic>Epilepsy</topic><topic>Families & family life</topic><topic>Gender roles</topic><topic>Genotype & phenotype</topic><topic>Handbooks</topic><topic>Health risk assessment</topic><topic>High functioning</topic><topic>Intellectual disabilities</topic><topic>Intelligence</topic><topic>Intelligence tests</topic><topic>Males</topic><topic>Medical diagnosis</topic><topic>Mental disorders</topic><topic>Mutation</topic><topic>Offspring</topic><topic>Parents & parenting</topic><topic>Psychiatry</topic><topic>Risk</topic><topic>Schizophrenia</topic><topic>Social classes</topic><topic>Socioeconomic factors</topic><topic>Volunteers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsuchiya, Kenji J</creatorcontrib><creatorcontrib>Matsumoto Kaori</creatorcontrib><creatorcontrib>Miyachi Taishi</creatorcontrib><creatorcontrib>Tsujii Masatsugu</creatorcontrib><creatorcontrib>Nakamura, Kazuhiko</creatorcontrib><creatorcontrib>Takagai Shu</creatorcontrib><creatorcontrib>Kawai Masayoshi</creatorcontrib><creatorcontrib>Yagi Atsuko</creatorcontrib><creatorcontrib>Iwaki Kimie</creatorcontrib><creatorcontrib>Suda Shiro</creatorcontrib><creatorcontrib>Sugihara Genichi</creatorcontrib><creatorcontrib>Iwata Yasuhide</creatorcontrib><creatorcontrib>Matsuzaki Hideo</creatorcontrib><creatorcontrib>Yoshimoto, Sekine</creatorcontrib><creatorcontrib>Suzuki, Katsuaki</creatorcontrib><creatorcontrib>Sugiyama Toshirou</creatorcontrib><creatorcontrib>Mori Norio</creatorcontrib><creatorcontrib>Takei Nori</creatorcontrib><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>Sociological Abstracts (pre-2017)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni 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Nori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paternal age at birth and high-functioning autistic-spectrumdisorder in offspring</atitle><jtitle>British journal of psychiatry</jtitle><date>2008-10-01</date><risdate>2008</risdate><volume>193</volume><issue>4</issue><spage>316</spage><epage>321</epage><pages>316-321</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>BackgroundPrevious studies have reported the association between advanced paternalage at birth and the risk of autistic-spectrum disorder in offspring,including offspring with intellectual disability.AimsTo test whether an association between advanced paternal age at birth isfound in offspring with high-functioning autistic-spectrum disorder (i.e.offspring without intellectual disability).MethodA case–control study was conducted in Japan. The participants consistedof individuals with full-scale IQ ⩾ 70, with a DSM–IV autistic disorderor related diagnosis. Unrelated healthy volunteers were recruited ascontrols. Parental ages were divided into tertiles (i.e. three ageclasses). Odds ratios and 95% confidence intervals were estimated usinglogistic regression analyses, with an adjustment for age, gender andbirth order.ResultsEighty-four individuals with autistic-spectrum disorder but withoutintellectual disability and 208 healthy controls were enrolled. Increasedpaternal, but not maternal, age was associated with an elevated risk ofhigh-functioning autistic-spectrum disorder. A one-level advance inpaternal age class corresponded to a 1.8-fold increase in risk, afteradjustment for covariates.ConclusionsAdvanced paternal age is associated with an increased risk forhigh-functioning autistic-spectrum disorder.</abstract><cop>London</cop><pub>Cambridge University Press</pub><doi>10.1192/bjp.bp.107.045120</doi><tpages>6</tpages></addata></record> |
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| subjects | Age Autism Birth Birth order Childbirth & labor Children & youth Childrens health Epilepsy Families & family life Gender roles Genotype & phenotype Handbooks Health risk assessment High functioning Intellectual disabilities Intelligence Intelligence tests Males Medical diagnosis Mental disorders Mutation Offspring Parents & parenting Psychiatry Risk Schizophrenia Social classes Socioeconomic factors Volunteers |
| title | Paternal age at birth and high-functioning autistic-spectrumdisorder in offspring |
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