Cerebral blood flow alterations specific to auditory verbalhallucinations in schizophrenia
BackgroundAuditory verbal hallucinations (AVHs) have been associated with deficitsin auditory and speech-related networks. However, the resting-statecerebral blood flow (CBF) alterations specific to AVHs in schizophreniaremain unknown.AimsTo explore AVH-related CBF alterations in individuals withsch...
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| Veröffentlicht in: | British journal of psychiatry 2017-03, Vol.210 (3), p.209-215 |
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| creator | Zhuo, Chuanjun Zhu, Jiajia Qin, Wen Qu, Hongru Ma, Xiaolei Yu, Chunshui |
| description | BackgroundAuditory verbal hallucinations (AVHs) have been associated with deficitsin auditory and speech-related networks. However, the resting-statecerebral blood flow (CBF) alterations specific to AVHs in schizophreniaremain unknown.AimsTo explore AVH-related CBF alterations in individuals withschizophrenia.MethodIn total, 35 individuals with schizophrenia with AVHs, 41 individualswith schizophrenia without AVHs and 50 controls underwent arterial spinlabelling magnetic resonance imaging. The CBF differences were voxel-wisecompared across the three groups.ResultsWe found AVH-specific CBF increase in the right superior temporal gyrusand caudate, and AVH-specific CBF decrease in the bilateral occipital andleft parietal cortices. We also observed consistent CBF changes in bothschizophrenia subgroups (i.e. those with and without AVHs) includingdecreased CBF in the bilateral occipital regions, the left lateralprefrontal and insular cortices, and the right anterior cingulate cortexand increased CBF in the bilateral lateral temporal regions and putamen,the left middle cingulate cortex and the right thalamus.ConclusionsThe AVH-specific CBF increases in the auditory and striatal areas and CBFreductions in the visual and parietal areas suggest that there exists aCBF redistribution associated with AVHs. |
| doi_str_mv | 10.1192/bjp.bp.115.174961 |
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However, the resting-statecerebral blood flow (CBF) alterations specific to AVHs in schizophreniaremain unknown.AimsTo explore AVH-related CBF alterations in individuals withschizophrenia.MethodIn total, 35 individuals with schizophrenia with AVHs, 41 individualswith schizophrenia without AVHs and 50 controls underwent arterial spinlabelling magnetic resonance imaging. The CBF differences were voxel-wisecompared across the three groups.ResultsWe found AVH-specific CBF increase in the right superior temporal gyrusand caudate, and AVH-specific CBF decrease in the bilateral occipital andleft parietal cortices. We also observed consistent CBF changes in bothschizophrenia subgroups (i.e. those with and without AVHs) includingdecreased CBF in the bilateral occipital regions, the left lateralprefrontal and insular cortices, and the right anterior cingulate cortexand increased CBF in the bilateral lateral temporal regions and putamen,the left middle cingulate cortex and the right thalamus.ConclusionsThe AVH-specific CBF increases in the auditory and striatal areas and CBFreductions in the visual and parietal areas suggest that there exists aCBF redistribution associated with AVHs.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.bp.115.174961</identifier><language>eng</language><publisher>London: Cambridge University Press</publisher><subject>Blood flow ; Cerebral blood flow ; Cortex ; Cortex (cingulate) ; Cortex (insular) ; Cortex (parietal) ; Hallucinations ; Hearing ; Magnetic resonance imaging ; Mental disorders ; Neostriatum ; Neuroimaging ; Occipital lobe ; Putamen ; Redistribution ; Resting ; Schizophrenia ; Speech ; Temporal cortex ; Thalamus ; Verbal hallucinations ; Visual cortex</subject><ispartof>British journal of psychiatry, 2017-03, Vol.210 (3), p.209-215</ispartof><rights>Copyright © Royal College of Psychiatrists, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,12845,27923,27924,30998</link.rule.ids></links><search><creatorcontrib>Zhuo, Chuanjun</creatorcontrib><creatorcontrib>Zhu, Jiajia</creatorcontrib><creatorcontrib>Qin, Wen</creatorcontrib><creatorcontrib>Qu, Hongru</creatorcontrib><creatorcontrib>Ma, Xiaolei</creatorcontrib><creatorcontrib>Yu, Chunshui</creatorcontrib><title>Cerebral blood flow alterations specific to auditory verbalhallucinations in schizophrenia</title><title>British journal of psychiatry</title><description>BackgroundAuditory verbal hallucinations (AVHs) have been associated with deficitsin auditory and speech-related networks. However, the resting-statecerebral blood flow (CBF) alterations specific to AVHs in schizophreniaremain unknown.AimsTo explore AVH-related CBF alterations in individuals withschizophrenia.MethodIn total, 35 individuals with schizophrenia with AVHs, 41 individualswith schizophrenia without AVHs and 50 controls underwent arterial spinlabelling magnetic resonance imaging. The CBF differences were voxel-wisecompared across the three groups.ResultsWe found AVH-specific CBF increase in the right superior temporal gyrusand caudate, and AVH-specific CBF decrease in the bilateral occipital andleft parietal cortices. We also observed consistent CBF changes in bothschizophrenia subgroups (i.e. those with and without AVHs) includingdecreased CBF in the bilateral occipital regions, the left lateralprefrontal and insular cortices, and the right anterior cingulate cortexand increased CBF in the bilateral lateral temporal regions and putamen,the left middle cingulate cortex and the right thalamus.ConclusionsThe AVH-specific CBF increases in the auditory and striatal areas and CBFreductions in the visual and parietal areas suggest that there exists aCBF redistribution associated with AVHs.</description><subject>Blood flow</subject><subject>Cerebral blood flow</subject><subject>Cortex</subject><subject>Cortex (cingulate)</subject><subject>Cortex (insular)</subject><subject>Cortex (parietal)</subject><subject>Hallucinations</subject><subject>Hearing</subject><subject>Magnetic resonance imaging</subject><subject>Mental disorders</subject><subject>Neostriatum</subject><subject>Neuroimaging</subject><subject>Occipital lobe</subject><subject>Putamen</subject><subject>Redistribution</subject><subject>Resting</subject><subject>Schizophrenia</subject><subject>Speech</subject><subject>Temporal cortex</subject><subject>Thalamus</subject><subject>Verbal hallucinations</subject><subject>Visual cortex</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNiktuwjAURa0KpIbPAjqzxDjBz4kTZYyKWAAjJpEdHMWR5efaTitYfTNgAYzOPbqHkC9gBUDLj2ryhfLLFgU0VVvDB8mgangOVS1WJGOMNTlwwT7JJsZp0bLiTUZuJx20CtJSZRHvdLD4R6VNOshk0EUave7NYHqakMr5bhKGB_3VQUk7Smvn3rhXaRyN_Wie6MegnZE7sh6kjXr_4pYczt_X0yX3AX9mHVM34RzccnW8BCFqUbZQvlf9A3TOS1s</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Zhuo, Chuanjun</creator><creator>Zhu, Jiajia</creator><creator>Qin, Wen</creator><creator>Qu, Hongru</creator><creator>Ma, Xiaolei</creator><creator>Yu, Chunshui</creator><general>Cambridge University Press</general><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20170301</creationdate><title>Cerebral blood flow alterations specific to auditory verbalhallucinations in schizophrenia</title><author>Zhuo, Chuanjun ; Zhu, Jiajia ; Qin, Wen ; Qu, Hongru ; Ma, Xiaolei ; Yu, Chunshui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_23155653913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Blood flow</topic><topic>Cerebral blood flow</topic><topic>Cortex</topic><topic>Cortex (cingulate)</topic><topic>Cortex (insular)</topic><topic>Cortex (parietal)</topic><topic>Hallucinations</topic><topic>Hearing</topic><topic>Magnetic resonance imaging</topic><topic>Mental disorders</topic><topic>Neostriatum</topic><topic>Neuroimaging</topic><topic>Occipital lobe</topic><topic>Putamen</topic><topic>Redistribution</topic><topic>Resting</topic><topic>Schizophrenia</topic><topic>Speech</topic><topic>Temporal cortex</topic><topic>Thalamus</topic><topic>Verbal hallucinations</topic><topic>Visual cortex</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhuo, Chuanjun</creatorcontrib><creatorcontrib>Zhu, Jiajia</creatorcontrib><creatorcontrib>Qin, Wen</creatorcontrib><creatorcontrib>Qu, Hongru</creatorcontrib><creatorcontrib>Ma, Xiaolei</creatorcontrib><creatorcontrib>Yu, Chunshui</creatorcontrib><collection>ProQuest Social Sciences Premium Collection【Remote access available】</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Research Library</collection><collection>Social Science Database (ProQuest)</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhuo, Chuanjun</au><au>Zhu, Jiajia</au><au>Qin, Wen</au><au>Qu, Hongru</au><au>Ma, Xiaolei</au><au>Yu, Chunshui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral blood flow alterations specific to auditory verbalhallucinations in schizophrenia</atitle><jtitle>British journal of psychiatry</jtitle><date>2017-03-01</date><risdate>2017</risdate><volume>210</volume><issue>3</issue><spage>209</spage><epage>215</epage><pages>209-215</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>BackgroundAuditory verbal hallucinations (AVHs) have been associated with deficitsin auditory and speech-related networks. However, the resting-statecerebral blood flow (CBF) alterations specific to AVHs in schizophreniaremain unknown.AimsTo explore AVH-related CBF alterations in individuals withschizophrenia.MethodIn total, 35 individuals with schizophrenia with AVHs, 41 individualswith schizophrenia without AVHs and 50 controls underwent arterial spinlabelling magnetic resonance imaging. The CBF differences were voxel-wisecompared across the three groups.ResultsWe found AVH-specific CBF increase in the right superior temporal gyrusand caudate, and AVH-specific CBF decrease in the bilateral occipital andleft parietal cortices. We also observed consistent CBF changes in bothschizophrenia subgroups (i.e. those with and without AVHs) includingdecreased CBF in the bilateral occipital regions, the left lateralprefrontal and insular cortices, and the right anterior cingulate cortexand increased CBF in the bilateral lateral temporal regions and putamen,the left middle cingulate cortex and the right thalamus.ConclusionsThe AVH-specific CBF increases in the auditory and striatal areas and CBFreductions in the visual and parietal areas suggest that there exists aCBF redistribution associated with AVHs.</abstract><cop>London</cop><pub>Cambridge University Press</pub><doi>10.1192/bjp.bp.115.174961</doi></addata></record> |
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| subjects | Blood flow Cerebral blood flow Cortex Cortex (cingulate) Cortex (insular) Cortex (parietal) Hallucinations Hearing Magnetic resonance imaging Mental disorders Neostriatum Neuroimaging Occipital lobe Putamen Redistribution Resting Schizophrenia Speech Temporal cortex Thalamus Verbal hallucinations Visual cortex |
| title | Cerebral blood flow alterations specific to auditory verbalhallucinations in schizophrenia |
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