Anti-cancer activities of cytokinin ribosides
Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as ant...
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| Veröffentlicht in: | Phytochemistry reviews 2019-08, Vol.18 (4), p.1101-1113 |
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| creator | Voller, Jiří Béres, Tibor Zatloukal, Marek Džubák, Petr Hajdúch, Marián Doležal, Karel Schmülling, Thomas Miroslav, Strnad |
| description | Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived from diverse malignancies including those with a mutant p53 gene. Activity against cancer stem cells, anti-angiogenic activity, and the ability to stimulate an immune response to malignant cells have been reported as well. There are also positive results from in vivo studies and reports of activity in patients with hematological malignancies and solid tumors. Here, we review studies of the anti-cancer activity of cytokinin ribosides since the 1960s and comment on the issues that need to be addressed for the further development of cytokinin ribosides into anti-cancer drugs. |
| doi_str_mv | 10.1007/s11101-019-09620-4 |
| format | Article |
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They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived from diverse malignancies including those with a mutant p53 gene. Activity against cancer stem cells, anti-angiogenic activity, and the ability to stimulate an immune response to malignant cells have been reported as well. There are also positive results from in vivo studies and reports of activity in patients with hematological malignancies and solid tumors. Here, we review studies of the anti-cancer activity of cytokinin ribosides since the 1960s and comment on the issues that need to be addressed for the further development of cytokinin ribosides into anti-cancer drugs.</description><identifier>ISSN: 1568-7767</identifier><identifier>EISSN: 1572-980X</identifier><identifier>DOI: 10.1007/s11101-019-09620-4</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Angiogenesis ; Antiangiogenics ; Anticancer properties ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Cancer ; Chemistry/Food Science ; Cytokinins ; Drug development ; Hormones ; Immune response ; Immunosuppressive agents ; In vivo methods and tests ; Life Sciences ; Organic Chemistry ; p53 Protein ; Plant Genetics and Genomics ; Plant growth ; Plant hormones ; Plant Sciences ; Solid tumors ; Stem cell transplantation ; Stem cells</subject><ispartof>Phytochemistry reviews, 2019-08, Vol.18 (4), p.1101-1113</ispartof><rights>Springer Nature B.V. 2019</rights><rights>Phytochemistry Reviews is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-88d45554a617256718b7724bb210303c2c1eca232a262a0a79f167c4e73364b33</citedby><cites>FETCH-LOGICAL-c319t-88d45554a617256718b7724bb210303c2c1eca232a262a0a79f167c4e73364b33</cites><orcidid>0000-0001-7378-8941</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11101-019-09620-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11101-019-09620-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids></links><search><creatorcontrib>Voller, Jiří</creatorcontrib><creatorcontrib>Béres, Tibor</creatorcontrib><creatorcontrib>Zatloukal, Marek</creatorcontrib><creatorcontrib>Džubák, Petr</creatorcontrib><creatorcontrib>Hajdúch, Marián</creatorcontrib><creatorcontrib>Doležal, Karel</creatorcontrib><creatorcontrib>Schmülling, Thomas</creatorcontrib><creatorcontrib>Miroslav, Strnad</creatorcontrib><title>Anti-cancer activities of cytokinin ribosides</title><title>Phytochemistry reviews</title><addtitle>Phytochem Rev</addtitle><description>Cytokinins are plant hormones and play essential roles in regulating plant growth and development. They also have diverse pharmacological effects in animals and humans. Whereas cytokinin bases have been studied mainly for their cytoprotective activities, cytokinin ribosides have been explored as anti-cancer agents. Cytokinin ribosides inhibit growth or cause apoptosis in various cell lines derived from diverse malignancies including those with a mutant p53 gene. Activity against cancer stem cells, anti-angiogenic activity, and the ability to stimulate an immune response to malignant cells have been reported as well. There are also positive results from in vivo studies and reports of activity in patients with hematological malignancies and solid tumors. Here, we review studies of the anti-cancer activity of cytokinin ribosides since the 1960s and comment on the issues that need to be addressed for the further development of cytokinin ribosides into anti-cancer drugs.</description><subject>Angiogenesis</subject><subject>Antiangiogenics</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer</subject><subject>Chemistry/Food Science</subject><subject>Cytokinins</subject><subject>Drug development</subject><subject>Hormones</subject><subject>Immune response</subject><subject>Immunosuppressive agents</subject><subject>In vivo methods and tests</subject><subject>Life Sciences</subject><subject>Organic Chemistry</subject><subject>p53 Protein</subject><subject>Plant Genetics and Genomics</subject><subject>Plant growth</subject><subject>Plant hormones</subject><subject>Plant Sciences</subject><subject>Solid tumors</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><issn>1568-7767</issn><issn>1572-980X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kEtLAzEUhYMoWKt_wNWA6-i9N6-ZZSm-QHCj4C5k0oyk6kxNUqH_3qkjuHN1z-J858LH2DnCJQKYq4yIgByw4dBoAi4P2AyVId7U8HK4z7rmxmhzzE5yXgMQakUzxhd9idy73odUOV_iVywx5GroKr8rw1vsY1-l2A45rkI-ZUede8_h7PfO2fPN9dPyjj883t4vFw_cC2wKr-uVVEpJp9GQ0gbr1hiSbUsIAoQnj8E7EuRIkwNnmg618TIYIbRshZizi2l3k4bPbcjFrodt6seXlgQqQQoQxxZNLZ-GnFPo7CbFD5d2FsHutdhJix212B8tVo6QmKA8lvvXkP6m_6G-Ac34YrI</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Voller, Jiří</creator><creator>Béres, Tibor</creator><creator>Zatloukal, Marek</creator><creator>Džubák, Petr</creator><creator>Hajdúch, Marián</creator><creator>Doležal, Karel</creator><creator>Schmülling, Thomas</creator><creator>Miroslav, Strnad</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X2</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0001-7378-8941</orcidid></search><sort><creationdate>20190801</creationdate><title>Anti-cancer activities of cytokinin ribosides</title><author>Voller, Jiří ; 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| subjects | Angiogenesis Antiangiogenics Anticancer properties Apoptosis Biochemistry Biomedical and Life Sciences Cancer Chemistry/Food Science Cytokinins Drug development Hormones Immune response Immunosuppressive agents In vivo methods and tests Life Sciences Organic Chemistry p53 Protein Plant Genetics and Genomics Plant growth Plant hormones Plant Sciences Solid tumors Stem cell transplantation Stem cells |
| title | Anti-cancer activities of cytokinin ribosides |
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