Detecting bliss synergy in in vivo combination studies with a tumor kinetic model

SUMMARY Linear models are generally reliable methods for analyzing tumor growth in vivo, with drug effectiveness being represented by the steepness of the regression slope. With immunotherapy, however, not all tumor growth follows a linear pattern, even after log transformation. Tumor kinetics model...

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Veröffentlicht in:Pharmaceutical statistics : the journal of the pharmaceutical industry 2019-11, Vol.18 (6), p.688-699
Hauptverfasser: Zhao, Wei, Vicini, Paolo, Novick, Steven, Anderton, Judith, Davies, Gareth, DAngelo, Gina, O'Day, Terrance, Yu, Binbing, Harper, Jay, Narwal, Rajesh, Roskos, Lorin, Yang, Harry
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Sprache:eng
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